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Drug: Taxotere
Nutrition: Calcium
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Total 17 results found since Jan 2013.
Effect of chemotherapy and different chemotherapy regimens on bone health among Chinese breast cancer women in different menstrual status: a self-control study
CONCLUSION: Chemotherapy might induce lumbar vertebrae BMD loss and spine osteoporosis with regimen differences among Chinese BC patients. Calcium/VitD supplementation could improve bone turnover markers, bone metabolism indicators, and bone mineral density. Early interventions on bone health are needed for BC patients during chemotherapy.PMID:37642751 | DOI:10.1007/s00520-023-07960-8
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Bai-Qing Peng Juan Wu Shen Tian Xiu-Quan Qu Xin-Yu Liang Jun-Han Feng Yu-Ling Chen Rui-Ling She Chen-Yu Ma Jing-Yu Song Zhao-Xing Li Zhi-Yu Jiang Kai-Nan Wu Ling-Quan Kong Source Type: research
Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial-mesenchymal Transition in Aggressive Variant Prostate Cancers
This study utilized bulk and single-cell or whole-transcriptome analysis [(RNA sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq)], and we observed greater expression of several EMT markers, including Vimentin, hyaluronan synthase-3, S100 calcium binding protein A6, TGFB1, CD44, CD55, and CD109 in European American and African American aggressive variant prostate cancer (AVPC) subtypes-mCRPC, neuroendocrine variant (NEPC), and taxane-resistant. The taxane-resistant gene FSCN1 was also expressed highly in single-cell subclonal populations in mCRPC. Furthermore, metronomic-topotecan single agent and combinations...
Source: Cell Research - July 21, 2023 Category: Cytology Authors: Taraswi Mitra Ghosh Suman Mazumder Joshua Davis Jyoti Yadav Ayuba Akinpelu Ahmed Alnaim Harish Kumar Razan Waliagha Allison E Church Bird Soroush Rais-Bahrami R Curtis Bird Panagiotis Mistriotis Amarjit Mishra Clayton C Yates Amit K Mitra Robert D Arnold Source Type: research
Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy
We describe the case of a middle-aged woman with gastric cancer. She was under treatment by fluorouracil, leucovorin, oxaliplatin, and docetaxel regimen and thrombocytopenia regimen after tumor progression, but developed unconsciousness, irritability, and headache shortly after initiation of treatment. Her magnetic resonance imaging in our hospital shows abnormal signals in bilateral frontal parietal occipital lobes with hyperintensities on T2-weighted magnetic resonance imaging and fluid-attenuated inversion recovery imaging, accompanied by the increased value of apparent diffusion coefficient. And T1-weighted images illu...
Source: Cancer Control - May 23, 2023 Category: Cancer & Oncology Authors: LinLin Xie Source Type: research
Engineered Microencapsulated Lactoferrin Nanoconjugates for Oral Targeted Treatment of Colon Cancer
This study provides the proof of concept for using NIMDs to enhance the effect of protein NPs in CRC treatment.PMID:37039769 | DOI:10.1021/acs.biomac.3c00037
Source: Biomacromolecules - April 11, 2023 Category: Biochemistry Authors: Yomna M Elmorshedy Mohamed Teleb Marwa A Sallam Kadria A Elkhodairy Mohammed Bahey-El-Din Doaa A Ghareeb Shaymaa A Abdulmalek Shimaa A H Abdel Monaim Adnan A Bekhit Ahmed O Elzoghby Fernando Albericio Sherine N Khattab Source Type: research
Alpha-tubulin relocalization is involved in calcium oxalate-induced tight junction disruption in renal epithelial cells
This study thus addressed the involvement of a major MT protein, α-tubulin, in COM-induced TJ disruption. Protein-protein interactions analysis demonstrated that α-tubulin directly interacted with a TJ protein, zonula occludens-1 (ZO-1). MDCK renal cells were polarized and incubated with COM crystals for 48 h. Western blotting showed that COM reduced ZO-1, but not α-tubulin, level. Immunofluorescence staining revealed COM-induced relocalization of α-tubulin from apical membranes to cytoplasm and ZO-1 disruption at cell borders. COM also mediated progressive fall of epithelial barrier function, represented by transepith...
Source: Chemico-Biological Interactions - November 9, 2022 Category: Molecular Biology Authors: Sudarat Hadpech Paleerath Peerapen Visith Thongboonkerd Source Type: research
Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment
Food Chem Toxicol. 2022 Sep 10:113421. doi: 10.1016/j.fct.2022.113421. Online ahead of print.ABSTRACTAnticancer agents can cause various side effects, including tissue damages/inflammatory reactions. Drug-responsive biomarkers are essential for evaluating drug toxicity in disease processes. S100 calcium-binding proteins A8/A9 (S100A8/A9) are highly expressed in neutrophils and monocytes/macrophages accumulated at inflammatory sites and are known to be related to tissue damage/inflammation; however, their response to drug toxicity has not been reported. Herein, we investigated the effects of anticancer agents (doxorubicin, ...
Source: Food and Chemical Toxicology - September 13, 2022 Category: Food Science Authors: Tomomi Morikawa-Ichinose Yoshinori Fujimura Motofumi Kumazoe Hiroaki Onda Daisuke Miura Hirofumi Tachibana Source Type: research
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment
Drug Deliv. 2022 Dec;29(1):889-905. doi: 10.1080/10717544.2022.2050845.ABSTRACTAs there is currently no effective therapy for patients with prostate cancer (PCa) bone metastasis, it was stringent to explore the relevant treatment strategies. Actually, the interaction between cancer cells and bone microenvironment plays important role in prostate cancer bone metastasis, especially the Sonic hedgehog protein (SHH) signaling in the bone microenvironment. The SHH promotes osteoblast maturation and osteoblast then secretes RANKL to induce osteoclastogenesis. Herein, this study develops bone-targeting calcium phosphate lipid hyb...
Source: Drug Delivery - March 14, 2022 Category: Drugs & Pharmacology Authors: Xiangyu Zhang Qingbin Liu Tingting Zhang Pei Gao Hui Wang Lu Yao Jingwen Huang Shulong Jiang Source Type: research
