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Drug: Dexamethasone
Procedure: DEXA Scan
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Total 62 results found since Jan 2013.
Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine
Toxicol Lett. 2023 Aug 18:S0378-4274(23)00243-6. doi: 10.1016/j.toxlet.2023.08.007. Online ahead of print.ABSTRACTHigenamine (Hige), a plant derived alkaloid is classified as β2 agonist by the World Anti-Doping Agency (WADA). However, pharmacologic mechanisms of its performance-enhancing activity have not been investigated so far. Therefore, we investigate the anabolic activity and associated molecular mechanisms of Hige in C2C12 myotubes. In differentiated C2C12 cells dose-dependent effects of Hige on myotube size were analyzed. The mRNA expression of genes involved in hypertrophy was measured. For mechanistic studies, Î...
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: L Jiang M Piribauer T Kostov S Steidel D A Bizjak J M Steinacker M Parr P Diel Source Type: research
Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19
CONCLUSIONS: ICU patients with COVID-19 who develop PF exhibit upregulated coagulation, inflammation, and neutrophil extracellular trap-related pathways as well as prolonged ICU length-of-stay and mortality. This study indicates that early dexamethasone treatment neither influences the incidence or clinical course of PF, nor clinical outcomes.PMID:37559053 | DOI:10.1186/s12931-023-02496-1
Source: Respiratory Care - August 9, 2023 Category: Respiratory Medicine Authors: Emma J Kooistra Kilian Dahm Antonius E van Herwaarden Jelle Gerretsen Melanie Nuesch Germano Karoline Mauer Ruben L Smeets Sjef van der Velde Maarten J W van den Berg Johannes G van der Hoeven Anna C Aschenbrenner Joachim L Schultze Thomas Ulas Matthijs K Source Type: research
Tanshinone I alleviates steroid-induced osteonecrosis of femoral heads and promotes angiogenesis: in vivo and in vitro studies
CONCLUSIONS: This study demonstrates that TsI alleviates SIONFH and promotes angiogenesis by regulating SOX11 expression. Our work would provide new evidence for the application of TsI to treat SIONFH.PMID:37391758 | DOI:10.1186/s13018-023-03934-y
Source: Cell Research - June 30, 2023 Category: Cytology Authors: Kai Sun Yuman Xue Xin Zhang Xiaodong Li Jun Zhao Xilin Xu Xiaofeng Zhang Fubiao Yang Source Type: research
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats
CONCLUSIONS: Nano-CU ameliorated lung damage induced by inhaled PQ similar to dexa and a synergic effect between nano-CU and PIO was observed, suggesting, a possible PPAR-γ receptor-mediated effect of curcumin.PMID:37039972 | DOI:10.1007/s43440-023-00483-3
Source: Pharmacological Reports - April 11, 2023 Category: Drugs & Pharmacology Authors: Seyedeh Zahra Ghasemi Sima Beigoli Sepideh Behrouz Zahra Gholamnezhad Nema Mohammadian Roshan Mohammad Hossein Boskabady Source Type: research
Paraquat-induced systemic inflammation and oxidative stress in rats improved by Curcuma longa ethanolic extract, curcumin and a PPAR agonist
Toxicon. 2023 Mar 23:107090. doi: 10.1016/j.toxicon.2023.107090. Online ahead of print.ABSTRACTThe effect of Curcuma longa (Cl) ethanolic extract, nano-curcumin (Cu) and a PPARγ activator, pioglitazone on inhaled paraquat (PQ)-induced systemic inflammation and oxidative stress was examined in the present study. Control rats were exposed to normal saline and PQ groups to 27 and 54 mg/m3 (PQ-L and PQ-H) aerosols. Nine other PQ-H groups were treated with Curcuma longa (Cl, 150 and 600 mg/kg/day), nano-curcumin (Cu, 2 and 8 mg/kg/day), pioglitazone (Pio, 5 and 10 mg/kg), low dose of Pio + Cl and Cu and dexamethasone (0.03 mg/...
Source: Toxicon - March 25, 2023 Category: Toxicology Authors: Seyedeh Zahra Ghasemi Sima Beigoli Arghavan Memarzia Sepideh Behrouz Zahra Gholamnezhad Majid Darroudi Fatemeh Amin Mohammad Hossein Boskabady Source Type: research
Efficacy of dexamethasone and N-acetylcysteine combination in preventing post-embolization syndrome after transarterial chemoembolization in hepatocellular carcinoma
CONCLUSION: Intravenous NAC + DEXA administration ameliorated the occurrence of PES event after cTACE in patients with intermediate-stage HCC.PMID:36816622 | PMC:PMC9932429 | DOI:10.3748/wjg.v29.i5.890
Source: World Journal of Gastroenterology : WJG - February 23, 2023 Category: Gastroenterology Authors: Nitipon Simasingha Wasu Tanasoontrarat Torpong Claimon Supatsri Sethasine Source Type: research
