Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19

CONCLUSIONS: ICU patients with COVID-19 who develop PF exhibit upregulated coagulation, inflammation, and neutrophil extracellular trap-related pathways as well as prolonged ICU length-of-stay and mortality. This study indicates that early dexamethasone treatment neither influences the incidence or clinical course of PF, nor clinical outcomes.PMID:37559053 | DOI:10.1186/s12931-023-02496-1

Source: Respiratory Care - August 9, 2023 Category: Respiratory Medicine Authors: Emma J Kooistra Kilian Dahm Antonius E van Herwaarden Jelle Gerretsen Melanie Nuesch Germano Karoline Mauer Ruben L Smeets Sjef van der Velde Maarten J W van den Berg Johannes G van der Hoeven Anna C Aschenbrenner Joachim L Schultze Thomas Ulas Matthijs K Source Type: research