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Drug: Dexamethasone
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Total 6433 results found since Jan 2013.
Should we be concerned when COVID-19-positive patients take opioids to control their pain? Insights from a pharmacological point of view
CONCLUSIONS: Clinicians should keep in mind the frequent DDIs with drugs extensively metabolized by the CYP450 system and prefer opioids undergoing a limited hepatic metabolism. Identification and management of DDIs and dissemination of the related knowledge should be a major goal in the delivery of chronic care to ensure optimized patient outcomes and facilitate updating recommendations for COVID-19 therapy in frail populations, namely comorbid, poly-medicated patients or individuals suffering from substance use disorder.PMID:34337735 | DOI:10.26355/eurrev_202107_26399
Source: Pharmacological Reviews - August 2, 2021 Category: Drugs & Pharmacology Authors: S Natoli R Carpenedo E Chin è F Vannicola F Leonardis M Dauri Source Type: research
Heliox for croup in children
CONCLUSIONS: Given the very limited available evidence, uncertainty remains regarding the effectiveness and safety of heliox. Heliox may not be more effective than 30% humidified oxygen for children with mild croup, but may be beneficial in the short term for children with moderate croup treated with dexamethasone. The effect of heliox may be similar to 100% oxygen given with one or two doses of adrenaline. Adverse events were not reported, and it is unclear if these were monitored in the included studies. Adequately powered RCTs comparing heliox with standard treatments are needed to further assess the role of heliox in t...
Source: Cochrane Database of Systematic Reviews - August 16, 2021 Category: General Medicine Authors: Irene Moraa Nancy Sturman Treasure M McGuire Mieke L van Driel Source Type: research
Investigation of the relaxing effect of a camphor nanoemulsion on rat isolated trachea
In conclusion, β-adrenergic receptors, prostanoids, nitric oxide (NO), ATP-sensitive K+ channels (KATP), Ca2+-opened K+ channels (KCa), and transient receptor potential cation channel subfamily V (TRPV) are involved in the relaxing effect of NEC. In addition, the mechanism of action of NEC may be involved with the signal transduction pathway Nitric Oxide/soluble guanylyl cyclase/cGMP/cGMP-activated protein kinase. NEC, therefore, demonstrates spasmolytic activity when presenting tracheal relaxation compared to CCh and KCl contracturants.PMID:34516975 | DOI:10.1016/j.cbi.2021.109656
Source: Chemico-Biological Interactions - September 13, 2021 Category: Molecular Biology Authors: Ma íra M Freitas Pedro M Cavalcante Luiz A M S Duarte-Filho Cicero A F Macedo Mariana C Brito Pedro M N Menezes Thiago F Ribeiro S âmara M Costa B árbara A G Carvalho Fernanda P R A Ribeiro Marigilson P S Moura Fabricio S Silva Luciano A A Ribeiro Source Type: research
Perineural Versus Intravenous Dexamethasone for Brachial Plexus Block: A Systematic Review and Meta-analysis of Randomized Controlled Trials
CONCLUSIONS: PN dexamethasone can prolong the duration of analgesia, sensory block, and motor block, when compared with IV dexamethasone. In a subgroup analysis without epinephrine, the 2 routes of administration were equivalent to topical anesthesia. There were no differences in secondary outcomes, except for adverse effects, which could be altered if a sensitivity analysis was conducted. Therefore, despite the advantages of PN dexamethasone, caution is needed due to its off-label character. While the results of this study are promising, additional large and well-designed RCTs are needed to validate these initial findings...
Source: Pain Physician - September 23, 2021 Category: Anesthesiology Authors: Tao Bei Junting Liu Qiulin Huang Jiaheng Wu Jinmin Zhao Source Type: research
Antenatal corticosteroids prior to planned caesarean at term for improving neonatal outcomes
CONCLUSIONS: Evidence from one randomised controlled trial suggests that prophylactic corticosteroids before elective caesarean section at term probably reduces admission to the neonatal intensive care unit for respiratory morbidity. It is uncertain if administration of antenatal corticosteroids reduces the rates of respiratory distress syndrome (RDS) or transient tachypnoea of the neonate (TTN). The overall certainty of the evidence for the primary outcomes was found to be low or very low, apart from the outcome of admission to neonatal special care (all levels) for respiratory morbidity, for which the evidence was of mod...
Source: Cochrane Database of Systematic Reviews - December 22, 2021 Category: General Medicine Authors: Alexandros Sotiriadis Emma McGoldrick George Makrydimas Stefania Papatheodorou John Pa Ioannidis Fiona Stewart Roses Parker Source Type: research
Nonopioid Analgesics for the Perioperative Geriatric Patient: A Narrative Review
Anesth Analg. 2022 Feb 24. doi: 10.1213/ANE.0000000000005944. Online ahead of print.ABSTRACTManagement of acute perioperative pain in the geriatric patient can be challenging as the physiologic and pharmacokinetic changes associated with aging may predispose older patients to opioid-related side effects. Furthermore, elderly adults are more susceptible to postoperative delirium and postoperative cognitive dysfunction, which may be exacerbated by both poorly controlled postoperative pain and commonly used pain medications. This narrative review summarizes the literature published in the past 10 years for several nonopioid a...
Source: Anesthesia and Analgesia - February 24, 2022 Category: Anesthesiology Authors: Sylvia H Wilson P Ryan Wilson Kathryn H Bridges L Hannah Bell Carlee A Clark Source Type: research
Hemophagocytic lymphohistiocytosis after SARS-CoV-2 vaccination
ConclusionCOVID-19 vaccines may occasionally trigger HLH, and Anakinra may be an efficacious treatment option for this condition.
Source: Infection - February 26, 2022 Category: Infectious Diseases Source Type: research
Therapeutic strategies for COVID-19 patients: An update
Infect Disord Drug Targets. 2022 Mar 22. doi: 10.2174/1871526522666220322145729. Online ahead of print.ABSTRACTThe novel coronavirus SARS-coV-2, which emerged in Wuhan in November 2019, has increasingly spread causing a global pandemic that infected more than 444 million people, resulting in severe social and economic ramifications, and claimed more than 6,010,000 lives by March 5, 2022. The pandemic attracted global attention with consequential multiple economic, social, and clinical studies. Among causes of poor clinical outcome of the disease are therapeutic challenges, leading to spirals of studies in search for better...
Source: Infectious Disorders Drug Targets - March 23, 2022 Category: Infectious Diseases Authors: Muhammad Ibrahim Getso Soudabeh Etemadi Vahid Raissi Moein Mohseni Maedeh Sadat Mohseni Farid Raeisi Omid Raiesi Source Type: research
Effect of Intravenous Dexamethasone on Postoperative Pain in Patients Undergoing Total Knee Arthroplasty: A Systematic Review and Meta-Analysis
CONCLUSIONS: Our results supported the addition of perioperative intravenous dexamethasone to multimodal analgesia in total knee arthroplasty to reduce postoperative pain, opioids consumption, and length of hospital stay. Current evidence did not support the superiority of repeated-dose dexamethasone over single-dose dexamethasone; thus, we recommended perioperative 8-10 mg intravenous dexamethasone to be used based on adequate basic analgesia; however, the results may have been affected by small sample sizes and heterogeneity.PMID:35322969
Source: Pain Physician - March 24, 2022 Category: Anesthesiology Authors: Shuang Liang Manyu Xing Shasha Jiang Wangyuan Zou Source Type: research
Therapeutic strategies for COVID-19 patients: An update
Infect Disord Drug Targets. 2022 Mar 22. doi: 10.2174/1871526522666220322145729. Online ahead of print.ABSTRACTThe novel coronavirus SARS-coV-2, which emerged in Wuhan in November 2019, has increasingly spread causing a global pandemic that infected more than 444 million people, resulting in severe social and economic ramifications, and claimed more than 6,010,000 lives by March 5, 2022. The pandemic attracted global attention with consequential multiple economic, social, and clinical studies. Among causes of poor clinical outcome of the disease are therapeutic challenges, leading to spirals of studies in search for better...
Source: Infectious Disorders Drug Targets - March 23, 2022 Category: Infectious Diseases Authors: Muhammad Ibrahim Getso Soudabeh Etemadi Vahid Raissi Moein Mohseni Maedeh Sadat Mohseni Farid Raeisi Omid Raiesi Source Type: research
Effect of Intravenous Dexamethasone on Postoperative Pain in Patients Undergoing Total Knee Arthroplasty: A Systematic Review and Meta-Analysis
CONCLUSIONS: Our results supported the addition of perioperative intravenous dexamethasone to multimodal analgesia in total knee arthroplasty to reduce postoperative pain, opioids consumption, and length of hospital stay. Current evidence did not support the superiority of repeated-dose dexamethasone over single-dose dexamethasone; thus, we recommended perioperative 8-10 mg intravenous dexamethasone to be used based on adequate basic analgesia; however, the results may have been affected by small sample sizes and heterogeneity.PMID:35322969
Source: Pain Physician - March 24, 2022 Category: Anesthesiology Authors: Shuang Liang Manyu Xing Shasha Jiang Wangyuan Zou Source Type: research
