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Drug: Dexamethasone
Nutrition: Sodium
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Total 153 results found since Jan 2013.
Direct drug milling in organic PLGA solution facilitates the encapsulation of nanosized drug into PLGA microparticles
The objective of this study was to prepare poly(lactide-co-glycolide) (PLGA) microparticles loaded with nanosized drug by combining non-aqueous wet bead milling and microencapsulation. 200 - 300 nm dexamethasone, hydrocortisone and dexamethasone sodium phosphate nanosuspensions were successfully prepared by wet bead milling the drug in dichloromethane using PLGA as a stabilizer. PLGA microparticles loaded with nanosized drugs were then prepared by a solid-in-oil-in-water (S/O/W) solvent evaporation method or solid-in-oil-in-oil (S/O/O) organic phase separation method. The microparticles were characterized by laser diffract...
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 14, 2023 Category: Drugs & Pharmacology Authors: Chenghao Zhang Roland Bodmeier Source Type: research
Study on the therapeutic effect of glucocorticoids on acute kidney injury in rats exposed to diquat
CONCLUSION: (1) Diquat can cause kidney damage in rats, mainly manifested as renal tubular atrophy, epithelial cell edema, capillary congestion and dilation, and the renal function damage indicators have been improved to varying degrees. (2) Glucocorticoids have therapeutic effects on acute kidney injury in rats exposed to diquat. During the treatment, the efficacy of glucocorticoids did not increase with increasing doses after reaching a dose of 4.2 mg/kg. (3) TLR4 receptor-mediated TLR4/Myd88/NF-κB signaling pathway is involved in the inflammatory response of acute kidney injury in diquat poisoning rats. Glucocorticoids...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 13, 2023 Category: Drugs & Pharmacology Authors: Siqi Cui Xiangxing Zhang Chen Wang Cece Sun Longke Shi Baotian Kan Qilu Li Xiangdong Jian Source Type: research
Ionically bridged dexamethasone sodium phosphate-zinc-PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis
Arch Pharm Res. 2023 Aug 3. doi: 10.1007/s12272-023-01456-z. Online ahead of print.ABSTRACTColon-targeted oral drug delivery systems comprising nanoparticles and microparticles have emerged as promising tools for the treatment of ulcerative colitis (UC) because they minimize side effects and maximize the local drug concentration. Dexamethasone sodium phosphate (DSP) is a potent anti-inflammatory glucocorticoid used for the treatment of UC. However, it remains a rather short-term treatment option owing to its side effects. In the present study, we developed the alginate gel encapsulating ionically bridged DSP-zinc-poly(lact...
Source: Archives of Pharmacal Research - August 3, 2023 Category: Drugs & Pharmacology Authors: Aruzhan Saparbayeva Juho Lee Shwe Phyu Hlaing Jihyun Kim Dongmin Kwak Hyunwoo Kim Eun Hee Lee Seonghwan Hwang Min-Soo Kim Hyung Ryong Moon Yunjin Jung Jin-Wook Yoo Source Type: research
Undescribed Phenolic Glycosides from Syzygium attopeuense and Their Inhibition of Nitric Oxide Production
Chem Biodivers. 2023 Aug 2:e202301037. doi: 10.1002/cbdv.202301037. Online ahead of print.ABSTRACTFour undescribed phenolic glycosides including three stilbene derivatives (1 and 3) and sodium salt of 3 (2), and a chalcone glycoside (4), together with thirteen known compounds (5-17) were isolated from the leaves of Syzygium attopeuense (Gagnep.) Merr. & L.M.Perry. Their chemical structures were elucidated to be (Z)-gaylussacin (1), 6''-O-galloylgaylussacin sodium salt (2), 6''-O-galloylgaylussacin (3), 4'-O-[β-D-glucopyranosyl-(1→6)-glucopyranosyl]oxy-2'-hydroxy-6'-methoxydihydrochalcone (4), gaylussacin (5), pinosi...
Source: Chemistry and Biodiversity - August 2, 2023 Category: Biochemistry Authors: Phan Van Kiem Bui Hai Ninh Bui Huu Tai Nguyen Xuan Nhiem Pham Hai Yen Nguyen Huy Hoang Do Thi Trang Duong Thi Dung Nguyen Van Tuyen Le Tuan Anh Source Type: research
Polymer coated polymeric microneedles for intravitreal delivery of dexamethasone
Exp Eye Res. 2023 Apr 7:109467. doi: 10.1016/j.exer.2023.109467. Online ahead of print.ABSTRACTThe polymer coated polymeric (PCP) microneedles (MNs) is a novel approach for controlled delivery of drugs (without allowing release of the excipients) to the target site. PCP MNs was explored as an approach to deliver the drug intravitreally to minimize the risks associated with conventional intravitreal injections. The core MNs was fabricated with polyvinyl pyrrolidone K30 (PVP K30) and coating was with Eudragit E100. Preformulation studies revealed that the films prepared using Eudragit E 100 exhibited excellent integrity in t...
Source: Experimental Eye Research - April 9, 2023 Category: Opthalmology Authors: Anusha V Matadh Deeksha Jakka S G Pragathi K Poornima H N Shivakumar Reena N Murthy Srinath Rangappa Mahesh Shivanna S Narasimha Murthy Source Type: research
Release Kinetics of Dexamethasone Phosphate from Porous Chitosan: Comparison of Aerogels and Cryogels
Biomacromolecules. 2023 Mar 23. doi: 10.1021/acs.biomac.2c01408. Online ahead of print.ABSTRACTPorous chitosan materials as potential wound dressings were prepared via dissolution of chitosan, nonsolvent-induced phase separation in NaOH-water, formation of a hydrogel, and either freeze-drying or supercritical CO2 drying, leading to "cryogels" and "aerogels", respectively. The hydrophilic drug dexamethasone sodium phosphate was loaded by impregnation of chitosan hydrogel, and the release from cryogel or aerogel was monitored at two pH values relevant for wound healing. The goal was to compare the drug-loading efficiency and...
Source: Biomacromolecules - March 23, 2023 Category: Biochemistry Authors: Coraline Chartier Sytze Buwalda Blessing C Ilochonwu H élène Van Den Berghe Audrey Bethry Tina Vermonden Martina Viola Benjamin Nottelet Tatiana Budtova Source Type: research
Mechanism of HSP90 inhibitor in the treatment of DSS-induced colitis in mice by inhibiting MAPK pathway and synergistic effect of Compound Sophora decoction
CONCLUSION: These data suggest that an HSP90 inhibitor is available to treat UC by inhibiting the MAPK signaling pathway. This axis can restore the intestinal mucosa barrier's function by reducing intestinal mucosa's permeability and inhibiting apoptosis of intestinal epithelial cells. The specific mechanism is that HSP90 inhibitor can reduce the pathological damage and inflammation levels of colitis mice, and reduce the apoptosis rate of colonic epithelial cells and the mucosal permeability, thereby restoring the mucosal barrier function. During this process, CSD works synergistically to improve the therapeutic effect of ...
Source: Current Pharmaceutical Design - November 23, 2022 Category: Drugs & Pharmacology Authors: Yuyi Yuan Hui Wu Bo Shuai Chang Liu Feng Zhu Fei Gao Chunzhu Wei Heng Fan Source Type: research
