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Premature Ventricular Complexes on Screening Electrocardiogram and Risk of Ischemic Stroke Brief Reports
Conclusions— PVCs are common on routine screening ECGs and are associated with an increased risk of ischemic stroke.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Agarwal, S. K., Chao, J., Peace, F., Judd, S. E., Kissela, B., Kleindorfer, D., Howard, V. J., Howard, G., Soliman, E. Z. Tags: Electrocardiology, Embolic stroke, Epidemiology Brief Reports Source Type: research

Primary Prophylactic Aspirin Use and Incident Stroke: Reasons for Geographic and Racial Differences in Stroke Study
Conclusions: In this observational study, prophylactic aspirin use was not associated with risk of first stroke, and there were no sex, race, or regional differences.
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2013 Category: Neurology Authors: Stephen P. Glasser, Martha K. Hovater, Daniel T. Lackland, Mary Cushman, George Howard, Virginia J. Howard Tags: Original Articles Source Type: research

Using Large-Scale Linkage Data to Evaluate the Effectiveness of a National Educational Program on Antithrombotic Prescribing and Associated Stroke Prevention in Primary Care Stroke
ConclusionsConsistent with NPS MedicineWise program messages for the high‐risk CVD population, the NPS MedicineWise Stroke Prevention Program (2009) was associated with increased initiation of aspirin and a reduced rate of hospitalization for primary stroke. The findings suggest that the provision of evidence‐based multifaceted large‐scale educational programs in primary care can be effective in changing prescriber behavior and positively impacting patient health outcomes.
Source: JAHA:Journal of the American Heart Association - October 12, 2016 Category: Cardiology Authors: Liu, Z., Moorin, R., Worthington, J., Tofler, G., Bartlett, M., Khan, R., Zuo, Y. Tags: Primary Prevention, Ischemic Stroke Original Research Source Type: research

Aspirin plus clopidogrel in acute minor ischaemic stroke or transient ischaemic attack is superior to aspirin alone for stroke risk reduction: CHANCE trial
Commentary on: Wang Y, Wang Y, Zhao X, et al.. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11–19. Context Combination therapy with aspirin added to clopidogrel has had a disappointing record in the prevention of recurrent stroke. The management of atherothrombosis with clopidogrel in high-risk patients (MATCH)1 and the secondary prevention of small subcortical strokes (SPS3)2 randomised controlled trials (RCTs) showed that combination therapy was not more effective than clopidogrel or aspirin alone, but was associated with two to three times the risk of major or ...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Gorelick, P. B., Farooq, M. U. Tags: Smoking and tobacco, Clinical trials (epidemiology), Genetics, Stroke, Hypertension, Diabetes, Health education, Smoking Therapeutics Source Type: research

Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials
Publication date: Available online 18 May 2016 Source:The Lancet Author(s): Peter M Rothwell, Ale Algra, Zhengming Chen, Hans-Christoph Diener, Bo Norrving, Ziyah Mehta Background Aspirin is recommended for secondary prevention after transient ischaemic attack (TIA) or ischaemic stroke on the basis of trials showing a 13% reduction in long-term risk of recurrent stroke. However, the risk of major stroke is very high for only the first few days after TIA and minor ischaemic stroke, and observational studies show substantially greater benefits of early medical treatment in the acute phase than do longer-term trials. ...
Source: The Lancet - May 19, 2016 Category: Journals (General) Source Type: research

UCLA, partners get $11M to develop stroke-prevention programs for minority populations
UCLA researchers and their partners across Los Angeles County have been awarded an $11 million federal grant to fund research on community-based interventions aimed at reducing the higher rates of stroke and death from stroke among disadvantaged Hispanics, African Americans and Asian Americans.   Research has shown that stroke risk can be substantially lowered by increasing physical activity, controlling blood pressure, adopting a healthy diet, quitting smoking, lowering cholesterol and, for certain individuals, taking medication like aspirin.   However, the underserved populations targeted by this research progr...
Source: UCLA Newsroom: Health Sciences - May 1, 2013 Category: Universities & Medical Training Source Type: news

The effect of a national quality improvement collaborative on prehospital care for acute myocardial infarction and stroke in England
Conclusions: This first national prehospital QIC led to significant improvements in ambulance care for AMI and stroke in England. The use of care bundles as measures, clinical engagement, application of quality improvement methods, provider prompts, individualized feedback and opportunities for learning and interaction within and across organizations helped the collaborative to achieve its aims.
Source: Implementation Science - January 23, 2014 Category: Health Management Authors: Aloysius SiriwardenaDeborah ShawNadya EssamFiona TogherZowie DavyAnne SpaightMichael Dewey Source Type: research

A high burden of ischemic stroke in regions of Eastern/Central Europe is largely due to modifiable risk factors.
Abstract Incidence and mortality of ischemic stroke in Croatia is significantly higher than in many other developed European countries. Here, we aimed to evaluate underlying conditions of this unacceptably high ischemic stroke burden. An observational prospective cohort study of ) first-ever ischemic stroke patients identified in a population-based incidence study (N=751) (study 1, S1) and a concurrent case-control trial (215 patients, 125 controls, S2) were conducted in the country of Varazdin from 2007-2010. Atrial fibrillation (AF) was common (36.1% in S1, 40.9% in S2) and mostly (>50%) unrecognized before t...
Source: Current Neurovascular Research - July 30, 2015 Category: Neurology Authors: Pikija S, Trkulja V, Malojcic B, Mutzenbach JS, Sellner J Tags: Curr Neurovasc Res Source Type: research

Overcoming Framing Bias in Stroke Neurologists' Assessments of the Minimally Clinically Important Difference for Novel Acute Ischemic Stroke Therapies (P4.187)
CONCLUSIONS: When assessed with framing based on clinical practice rather than convenience, vascular neurologists indicated the MCID for a safe agent to be worthwhile to use in acute ischemic stroke is about 1[percnt]. Drug and device agencies should consider this value to be the expert opinion MCID for acute ischemic stroke treatments when making regulatory decisions.Disclosure: Dr. Cranston has nothing to disclose. Dr. Kaplan has nothing to disclose. Dr. Saver has received personal compensation for activities with the University of California, BrainsGate, CoAxia, eV3, Talecris Biotherapeutics Inc., and PhotoThera, Inc.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Cranston, J., Kaplan, B., Saver, J. Tags: Research Methodology and Education Source Type: research

Delay of Percutaneous Gastrostomy Tube (PEG) Placement in Patients with Ischemic Stroke in a Large Urban Hospital. (P1.063)
CONCLUSIONS: Our study shows that hypertension, use of AA agents and use of tPA puts stroke patients at risk of having a delay in PEG placement. Prior studies have shown that aspirin use is not associated with increased bleeding complications during PEG placement. Education can help avoid delay in PEG tube placement due to aspirin use. Early PEG placement in ischemic stroke patients may improve clinical outcome and decrease hospital costs.Disclosure: Dr. Raval has nothing to disclose. Dr. Rayi has nothing to disclose. Dr. Jacob has nothing to disclose. Dr. Hillen has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Raval, B., Rayi, A., Jacob, M., Hillen, M. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

Factors Influencing Oral Anticoagulant Prescribing Practices for Atrial Fibrillation among Cardiologists, Internists, and Vascular Neurologists (P1.227)
Conclusions: Medical specialties differ in their reasons for selecting NOACs over warfarin and in their use of aspirin with warfarin. Educational interventions may prevent misinterpretations of clinical trial results, particularly with regards to comparative efficacy in the prevention of ischemic stroke and intracerebral hemorrhage. Disclosure: Dr. Leung has nothing to disclose. Dr. Mcallister has nothing to disclose. Dr. Selim has nothing to disclose. Dr. Fisher has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Leung, L., Mcallister, M., Selim, M., Fisher, M. Tags: Cardiac Mechanisms and Complications of Stroke Source Type: research

Stroke in atrial fibrillation patients already on oral anticoagulant: What more can be done?
Abstract Oral anticoagulants dramatically reduce the risk of embolic stroke in patients with atrial fibrillation (AF). However, each year, 1 to 3 % of patients will present an ischemic stroke despite being on oral anticoagulant. These events can result from efficacy fluctuations, non-cardioembolic stroke, or insufficient efficacy despite appropriate anticoagulation. There are several therapeutic options depending on presumed mechanism of ischemic stroke. However, none of these options has been specifically evaluated in appropriate studies. These options include: reinforcement of education or change in VKA drugs ...
Source: Presse Medicale - May 27, 2014 Category: Journals (General) Authors: Touzé E, Ciocanu D Tags: Presse Med Source Type: research

Effects of Antiplatelet Agents on Functional Outcome and Cognitive Status in Patients with Acute Ischemic Stroke
Conclusion The use of antiplatelet agents in acute ischemic stroke may have a favorable effect on functional outcome and cognitive status in patients at 3 months poststroke.
Source: International Journal of Gerontology - November 17, 2014 Category: Geriatrics Source Type: research

MRI ameliorates the prediction of further clinical evolution even months after ischemic stroke
Publication date: September 2015 Source:Annals of Physical and Rehabilitation Medicine, Volume 58, Supplement 1 Author(s): V. Quintaine, H. Chabriat, E. Jouvent, A. Yelnik Background Late recovery after a first ischemic stroke is highly variable and its predictors are unknown. The present study aims at determining whether MRI data obtained one to four months after a first ischemic stroke help to predict clinical evolution up to 2 years. Methods Patients included in the PERFORM MRI study, an ancillary study of the PERFORM randomized control trial of terutroban against aspirin in secondary prevention of vascular ische...
Source: Annals of Physical and Rehabilitation Medicine - October 2, 2015 Category: Rehabilitation Source Type: research

Articles Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials
Our findings confirm that medical treatment substantially reduces the risk of early recurrent stroke after TIA and minor stroke and identify aspirin as the key intervention. The considerable early benefit from aspirin warrants public education about self-administration after possible TIA. The previously unrecognised effect of aspirin on severity of early recurrent stroke, the diminishing benefit with longer-term use, and the contrasting time course of effects of dipyridamole have implications for understanding mechanisms of action.
Source: LANCET - May 17, 2016 Category: Journals (General) Authors: Peter M Rothwell, Ale Algra, Zhengming Chen, Hans-Christoph Diener, Bo Norrving, Ziyah Mehta Tags: Articles Source Type: research

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