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Total 104 results found since Jan 2013.

Interaction of pre and postnatal nutrition on expression of leptin receptor variants and transporter molecules, leptin transport, and functional response to leptin in heifers †
Biol Reprod. 2023 Sep 12:ioad118. doi: 10.1093/biolre/ioad118. Online ahead of print.ABSTRACTPerinatal nutrition modulates the hypothalamic neurocircuitries controlling GnRH release, thus programming pubertal maturation in female mammals. Objectives of experiments reported here were to test the hypotheses that prenatal nutrition during mid- to late gestation interacts with postnatal nutrition during the juvenile period in heifer offspring to alter expression of leptin receptor (LepR) variants (ObRa, ObRb, ObRc, ObRt), and lipoprotein transporter molecules (LRP1 and 2) in the choroid plexus, leptin transport across the bloo...
Source: Biology of Reproduction - September 12, 2023 Category: Reproduction Medicine Authors: Gary L Williams Youwen Zhang Meaghan M O'Neil Tatiane S Maia Sarah M West Bruna R C Alves Viviana Garza Thomas H Welsh Rodolfo C Cardoso Source Type: research

Resting energy metabolism and sweet taste preference during the menstrual cycle in healthy women
Br J Nutr. 2023 Aug 29:1-19. doi: 10.1017/S0007114523001927. Online ahead of print.ABSTRACTDifferences in blood concentration of sex hormones in the follicular (FP) and luteal (LP) phases may influence energy metabolism in women. We compared fasting energy metabolism and sweet taste preference on a representative day of the FP and LP in 20 healthy women (25.3±5.1 years, BMI: 22.2±2.2 kg/m2) with regular self-reported menses and without the use of hormonal contraceptives. From the self-reported duration of the three prior menstrual cycles, the predicted FP and LP visits were scheduled for days 5 to 12 and 20 to 25 after m...
Source: The British Journal of Nutrition - August 29, 2023 Category: Nutrition Authors: Lorena Malo-Vintimilla Carolina Aguirre Angie Vergara Rodrigo Fern ández-Verdejo Jose E Galgani Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The association of sex steroid hormone concentrations with hearing loss: a cross-sectional study
CONCLUSION: Our research indicated that low estradiol concentrations were significantly associated with hearing loss, especially in menopausal women.PMID:37354484 | DOI:10.1080/00016489.2023.2224398
Source: Acta Oto-Laryngologica - June 24, 2023 Category: ENT & OMF Authors: Huifen Yang Jing Li Xinyuan Sun Wangwei Li Yuan Wang Caiqin Huang Source Type: research

Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies
Nutr Cancer. 2023 May 31:1-21. doi: 10.1080/01635581.2023.2219027. Online ahead of print.ABSTRACTAmong luminal types of breast cancers, ER + breast cancer is the most frequently diagnosed cancer globally. ER + breast cancer is commonly treated with SERM drugs that block ER to prevent ER-mediated cancerous growth. Our previous computational screening found pelargonidin (PG) can inhibit ER-signaling with potent bioactivity and satisfactory toxicological features. The present study explored the anti-tumoral prospect of PG against DMBA-induced ER + murine mammary carcinogenesis. The female BALB/c mice were divided into control...
Source: Nutrition and Cancer - May 31, 2023 Category: Cancer & Oncology Authors: Yahyea Baktiar Laskar Kasturi Bhattacharjee Moumita Nath Yashmin Choudhury Pranab Behari Mazumder Anupam Das Talukdar Source Type: research

Rooibos (Aspalathus linearis) and its constituent quercetin can suppress ovarian cell functions and their response to FSH
Physiol Res. 2023 Apr 30;72(2):269-280.ABSTRACTRooibos (Aspalathus linearis Brum. f) can directly influence female reproduction, but whether rooibos can influence the response of ovarian cells to FSH and whether the rooibos effects are due to the presence of quercetin remain unknown. We compared the influence of rooibos extract and quercetin (both at 10 µg/ml-1) on porcine ovarian granulosa cells cultured with and without FSH (0, 1, 10 or 100 ng/ml-1). The expression of intracellular proliferation (PCNA, cyclin B1) and apoptosis (bax, caspase 3) markers in the cells was detected by immunocytochemistry. The release of prog...
Source: Cell Research - May 9, 2023 Category: Cytology Authors: A V Sirotkin Z Fabova W Aldahmash A Alshamrani A H Harrath Source Type: research