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Drug: Estradiol
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Total 251 results found since Jan 2013.
Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: a comparative study with 17 β-estradiol
Publication date: Available online 4 May 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Teresa Jover-Mengual, María Castelló-Ruiz, María C. Burguete, María Jorques, Mikahela A. López-Morales, Alicia Aliena-Valero, Andrés Jurado-Rodríguez, Salvador Pérez, José M. Centeno, Francisco J. Miranda, Enrique Alborch, Germán Torregrosa, Juan B. Salom As the knowledge on the estrogenic system in the brain grows, the possibilities to modulate it in order to afford further neuroprotection in brain damaging disorders so do it. We have previously demonstrated the ability of the selective estr...
Source: The Journal of Steroid Biochemistry and Molecular Biology - May 5, 2017 Category: Biochemistry Source Type: research
Associations of endogenous estradiol and testosterone levels with plaque composition and risk of stroke in subjects with carotid atherosclerosis
Background: Carotid atherosclerosis remains an important etiological factor of ischemic stroke. Sex differences have been observed in carotid plaque composition and in stroke incidence. Sex steroids have been suggested to count for these sex differences, but the evidence in humans is limited. Therefore, we aimed to study the associations of endogenous estradiol and testosterone with carotid plaque composition in middle-aged and elderly men and postmenopausal women with carotid atherosclerosis, as well as with risk of stroke in this population.
Source: Maturitas - August 2, 2017 Category: Primary Care Authors: Marija Glisic, Blerim Mujaj, Oscar L. Rueda-Ochoa, Eralda Asllanaj, Joop S.E. Laven, Maryam Kavousi, M. Kamran Ikram, Meike W. Vernooij, M. Arfan Ikram, Oscar H. Franco, Daniel Bos, Taulant Muka Source Type: research
Potential biomarkers with plasma cortisol, brain-derived neurotrophic factor and nitrites in patients with acute ischemic stroke.
CONCLUSION: Nitrites and BDNF may represent potential biomarkers for cortisol negative effects on the area of cerebral ischemia and penumbra, potentiating ischemic cell damage.
PMID: 28982330 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - October 5, 2017 Category: Neurology Authors: Casas S, Perez AF, Mattiazzi M, Lopez J, Folgueira A, Gargiulo-Monachelli GM, Deniselle MCG, De Nicola AF Tags: Curr Neurovasc Res Source Type: research
Oral contraceptives and stroke: Foes or friends
Front Neuroendocrinol. 2022 Jul 20:101016. doi: 10.1016/j.yfrne.2022.101016. Online ahead of print.ABSTRACTIncidents of strokes are increased in young women relative to young men, suggesting that oral contraceptive (OC) use is one of the causes of stroke among young women. Long-term exposures to the varying combinations of estrogen and progestogen found in OCs affect blood clotting, lipid and lipoprotein metabolism, endothelial function, and de novo synthesis of neurosteroids, especially brain-derived 17β-estradiol. The latter is essential for neuroprotection, memory, sexual differentiation, synaptic transmission, and beh...
Source: Frontiers in Neuroendocrinology - July 23, 2022 Category: Endocrinology Authors: Varun Reddy Megan Wurtz Shahil H Patel Micheline McCarthy Ami P Raval Source Type: research
A Review of the Relationships between Endogenous Sex Steroids and Incident Ischemic Stroke and Coronary Heart Disease Events.
Authors: Kim C, Cushman M, Kleindorfer D, Safford MM, Redberg RF, Lisabeth L
Abstract
For decades, it has been recognized that men have a higher age-adjusted risk of ischemic cardiovascular (CVD) events compared to women, thus generating hypotheses that sex steroids contribute to CVD risk. Potential mechanisms include genomic and non-genomic effects of sex steroids as well as mediation through classic CVD risk factors and obesity. However, results from randomized studies suggest that sex steroid supplementation in men and women do not result in improved CVD outcomes and may increase CVD risk. In contrast, prospecti...
Source: Current Cardiology Reviews - January 8, 2015 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
Sex hormones and ischemic stroke: a prospective cohort study and meta-analyses.
CONCLUSIONS: Extreme low endogenous testosterone concentrations were associated with high risk of IS in men, a risk mediated in part by body mass index and hypertension. Whether or not low testosterone is a causal factor for IS or merely a biomarker of poor metabolic health is still not known.
PMID: 26509870 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 28, 2015 Category: Endocrinology Authors: Holmegard HN, Nordestgaard BG, Jensen GB, Tybjærg-Hansen A, Benn M Tags: J Clin Endocrinol Metab Source Type: research
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes
Horm Metab Res DOI: 10.1055/s-0042-119201Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS). Neuroactive steroids are cholesterol-derived hormones that have the ability to modulate the normal and pathologic nervous system employing genomic and nongenomic mechanisms. In this work, we first investigated if AIS affects the plasma concentration of 5 neuroactive steroids (cortisol, estradiol, progesterone, testosterone, and 3α-androstenediol glucuronide). Second, we studied if levels of circulating steroids asso...
Source: Hormone and Metabolic Research - November 2, 2016 Category: Endocrinology Authors: Casas, S. Gonzalez Deniselle, M. C. Gargiulo-Monachelli, G. M. Perez, A. F. Tourreilles, M. Mattiazzi, M. Ojeda, C. Lotero Polesel, D. G. De Nicola, A. F. Tags: Endocrine Care Source Type: research
