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Drug: Metformin
Nutrition: Herbs
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Total 71 results found since Jan 2013.
Salvia Officinalis Improves Glucose Uptake and Suppresses Ectopic Lipid Deposition in Obese Rats with Metabolic Syndrome
CONCLUSION: The findings imply that SAGEAE could be used as a new pharmaceutical formula in the treatment of obesity.PMID:37581324 | DOI:10.2174/1389201024666230811104740
Source: Current Pharmaceutical Biotechnology - August 15, 2023 Category: Biotechnology Authors: Diana A ALsherif Mohammed A Hussein Suzan S Abuelkasem Soha A Hassan Michael Wink Source Type: research
< em > Cinnamomum cassia < /em > on Arterial Stiffness and Endothelial Dysfunction in Type 2 Diabetes Mellitus: Outcomes of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial
This study aimed to evaluate the effect of C. cassia on arterial stiffness and endothelial dysfunction (ED) in patients with type 2 diabetes mellitus (T2DM). A randomized, double-blind, placebo-controlled clinical trial was carried out in 18 subjects aged 40-65 years, with a diagnosis of T2DM of one year or less since diagnosis and treated with Metformin 850 mg daily. Patients were randomly assigned to receive either C. cassia or a placebo in 1000 mg capsules, thrice a day, before each meal for 12 weeks. At baseline and after 12 weeks of intervention, brachial-ankle pulse wave velocity and Flow Mediated Dilation were measu...
Source: Molecular Medicine - June 1, 2023 Category: Molecular Biology Authors: Jes ús S Delgadillo-Centeno Fernando Grover-P áez Sandra O Hern ández-González Mar ía G Ramos-Zavala David Cardona-M üller Alicia L ópez-Castro Sara Pascoe-Gonz ález Source Type: research
Ameliorative effect of Arabic gum Acacia and mori extracts in streptozotocin-induced diabetic rats: implications of Cas-3 and TGF- β
CONCLUSIONS: Oral treatment of metformin with AG and FM in STZ-injected rats could ameliorate protective pathways and can be one of the promising oral anti-diabetic herbal agents.PMID:37070884 | DOI:10.26355/eurrev_202304_31915
Source: Pharmacological Reviews - April 18, 2023 Category: Drugs & Pharmacology Authors: R A El-Shafei M A El-Adl H S Ali Y Nomier Source Type: research
Antidiabetic and antioxidant activities of Mitragyna speciosa (kratom) leaf extract in type 2 diabetic rats
This study investigated the antidiabetic effects of M. speciosa (Krat) ethanolic extract on fructose and streptozocin (STZ)-induced type 2 diabetic rats. In vitro antioxidant and antidiabetic effects were evaluated using DPPH, ABST, FRAP and α-glucosidase inhibitory assays. Rats with fructose/STZ induced T2D were treated with Krat (100 and 400 mg/kg) or metformin (200 mg/kg) for 5 weeks via oral gavage. Krat showed good antioxidant activity and also displayed potent α-glucosidase inhibitory activity. Administration of Krat to the diabetic rats significantly improved body weight gain, restored alterations in blood glucose...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Pengpeng Zhang Wei Wei Xiaohai Zhang Chaoling Wen Chitchamai Ovatlarnporn Opeyemi Joshua Olatunji Source Type: research
Integrative approach to uncover antioxidant properties of Bupleuri Radix and its active compounds: Multiscale interactome-level analysis with experimental validation
Free Radic Biol Med. 2023 Feb 23:S0891-5849(23)00081-3. doi: 10.1016/j.freeradbiomed.2023.02.016. Online ahead of print.ABSTRACTAcute and chronic liver disease are global problems with high morbidity and mortality. Bupleuri Radix (BR) is an herbal medicine that has been prescribed empirically in traditional Asian medicine to modulate liver metabolism. However, its active compounds and therapeutic mechanisms remain unclear. Here, we integrated a network-based approach and experimental validation to elucidate BR's therapeutic potential in treating oxidative liver injury. Our approach incorporated data collection and network ...
Source: Free Radical Biology and Medicine - February 25, 2023 Category: Biology Authors: Seon Been Bak Yu Rim Song Su-Jin Bae Won-Yung Lee Young Woo Kim Source Type: research
Preliminary Study of the Distinctive Mechanism of Shenqi Compound in Treating Rats with Type 2 Diabetes Mellitus by Comparing with Metformin
CONCLUSION: Comparing SQC with metformin to treat T2DM rats revealed several potential gene targets. These genes provide clues for elucidating the therapeutic mechanisms of SQC.PMID:36752289 | DOI:10.2174/1570161121666230208130349
Source: Current Vascular Pharmacology - February 8, 2023 Category: Drugs & Pharmacology Authors: Xiaoxu Fu Xiujuan Zhou Ya Liu Yuanhong Lei Hongyan Xie Yulin Leng Hong Gao Chunguang Xie Source Type: research
Medication Safety in Breastfeeding
Am Fam Physician. 2022 Dec;106(6):638-644.ABSTRACTBreastfeeding is universally recognized as the preferred method of infant nutrition, but is sometimes abbreviated because of fear of harm to the infant from maternal medication. The amount of medication that enters breast milk varies based on the maternal serum concentration and the pharmacologic properties of the medication. When prescribing medications for a breastfeeding patient, those with the lowest risk to the infant should be selected, and dosing should be before the infant's longest sleep interval. Prescribers should use current, accurate resources. LactMed is a con...
Source: American Family Physician - December 15, 2022 Category: Primary Care Authors: Jeanne P Spencer Stephanie Thomas Ruth H Trondsen Pawlowski Source Type: research
The efficacy of Da Chaihu decoction combined with metformin tablets for type 2 diabetes mellitus: A systematic review and meta-analysis
CONCLUSIONS: Very low-quality research shows that Da Chaihu decoction combined with metformin tablets exert a certain level of efficacy on patients with type 2 diabetes compared with metformin alone. However, random sequence generation methodology was reported in five studies leading to the low quality of the included studies. None of the six studies depicted the blinding method, allocation concealment, selective reporting, and assessed the purity and potency of the product. This observation requires verification through high-quality, multi-center, double-blinded randomized controlled trials, and assesses the purity and po...
Source: Complementary Therapies in Medicine - October 23, 2022 Category: Complementary Medicine Authors: Jia-Bin Wang Yan-Xia Wang Fen Li Yan-Fei Li Xing-Li Li Pei-Yao Huang Chen Wang Meng Wang Jie Qiu Ke-Hu Yang Wen-Wen Qiu Lu Liu Bao-Hong Mao Hong-Pu Li Xu-Dong Liu Fu-Yun Li Xu-Dong Cui Peng-Ju Wang Wen-Bo Liu Source Type: research
