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Drug: Methotrexate

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Anti-Inflammatory and Anti-Arthritic Efficacies of an Indian Traditional Herbo-Mineral Medicine “Divya Amvatari Ras” in Collagen Antibody-Induced Arthritis (CAIA) Mouse Model Through Modulation of IL-6/IL-1β/TNF-α/NFκB Signaling
Rheumatoid arthritis (RA) is defined as a chronic autoimmune inflammatory disorder that causes damage to limb joints and progressive injuries to secondary organs. Medical practitioners prescribe Methotrexate (MTX) as standard care medicine for treating RA. However, long-term application of MTX has shown to have adverse health-related effects. Divya Amvatari Ras (DAR), an Indian Ayurvedic herbo-mineral formulation has been described in ancient texts to provide relief from RA inflammation associated distress. Therefore, in the present study, we explored the biocompatibility, anti-inflammatory and anti-arthritic efficacy of D...
Source: Frontiers in Pharmacology - June 30, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics of Chemotherapeutic Drugs in Pediatric Patients With Down Syndrome and Leukemia
Children with Down syndrome (DS) have a 10- to 30-fold increased risk of developing acute myeloid leukemia or acute lymphoblastic leukemia. Patients with DS and leukemia are treated with the same chemotherapeutic agents as patients without DS. Treatment regimens for pediatric leukemia comprise multiple cytotoxic drugs including methotrexate, doxorubicin, vincristine, cytarabine, and etoposide. There have been reports of increased toxicity, as well as altered therapeutic outcomes in pediatric patients with DS and leukemia. This review is focused on the pharmacokinetics of cytotoxic drugs in pediatric patients with leukemia ...
Source: Journal of Pediatric Hematology Oncology - April 28, 2016 Category: Hematology Tags: Review Articles Source Type: research

Methotrexate metabolism and bilirubin levels as predictors of oral mucositis in pediatric oncologic patients
ConclusionsSerum metabolite concentration of MTX and BB should be monitored as relative predictors of higher OM risk.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Drug-Related Adverse Events Necessitating Treatment Discontinuation in Pediatric Inflammatory Bowel Disease Patients
Conclusions: Drug-related AE necessitating discontinuation are common in pediatric and adolescent IBD patients. Caution needs to be taken in the case of concomitant drug use.
Source: Journal of Pediatric Gastroenterology and Nutrition - November 24, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Takayasu Arteritis in the pediatric population: a contemporary United States-Based Single Center Cohort
Conclusion: Our study emphasizes that constitutional symptoms coupled with objective findings of diminished pulses, bruits, and hypertension should raise clinical suspicion for Takayasu Arteritis in pediatric patients. Pharmacologic therapy alone can be successful in controlling disease progression, however surgery was successful in minimizing symptoms when medical therapies failed.
Source: Pediatric Rheumatology - June 4, 2014 Category: Rheumatology Authors: Heidi SzugyeAndrew ZeftSteven Spalding Source Type: research

Advanced Therapy for Inflammatory Bowel Disease: A Guide for the Primary Care Physician
This article discusses general concepts about azathioprine, 6-mercaptopurine, methotrexate, and common biologic drugs used in IBD.
Source: Journal of the American Board of Family Medicine - May 7, 2014 Category: Primary Care Authors: Thomas, A., Lodhia, N. Tags: Clinical Reviews Source Type: research

Comparable efficacy with varying dosages of glucarpidase in pediatric oncology patients
ConclusionsThe efficacy of glucarpidase in the treatment of HDMTX‐induced kidney injury was not dosage‐dependent in this retrospective analysis of pediatric oncology patients. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - January 28, 2015 Category: Cancer & Oncology Authors: Jeffrey R. Scott, Yinmei Zhou, Cheng Cheng, Deborah A. Ward, Hope D. Swanson, Alejandro R. Molinelli, Clinton F. Stewart, Fariba Navid, Sima Jeha, Mary V. Relling, Kristine R. Crews Tags: Research Article Source Type: research

The Future Is Now: Biologics for Non-Infectious Pediatric Anterior Uveitis
Abstract Anterior uveitis (AU), inflammation of the iris, choroid or ciliary body, can cause significant eye morbidity, including visual loss. In the pediatric age group, the most common underlying diagnosis for AU is juvenile idiopathic associated uveitis and idiopathic AU, which are the focus of this paper. AU is often resistant to medications such as topical corticosteroids and methotrexate. In the past 15 years, biologic agents (biologics) have transformed treatment. In this review, we discuss those in widespread use and those with more theoretical applications for anterior uveitis. Tumor necrosis factor alph...
Source: Pediatric Drugs - April 17, 2015 Category: Pediatrics Source Type: research

Recurrent Pediatric Perianal Swelling.
Abstract Pediatric inflammatory bowel disease is a chronic gastrointestinal disease consisting of Crohn's disease (CD) and ulcerative colitis (UC). Both disease processes can share similar clinical symptoms including abdominal pain, diarrhea, hematochezia, and weight loss; CD can also be complicated by penetrating and fistulizing disease. Perianal skin tags, perianal abscesses, recto-cutaneous fistulae, and rectal stenosis are among the phenotypic characteristics of perianal CD. Current treatment strategies are focused on the surgical drainage of abscesses and the closure of fistulous tracts as well as controlling...
Source: Pediatric Annals - February 1, 2016 Category: Pediatrics Authors: Cordova J, Chugh A, Rivera Rivera ED, Young S Tags: Pediatr Ann Source Type: research

Ustekinumab in Pediatric Crohn Disease Patients
Conclusions: Ustekinumab was used in 4 children with pediatric Crohn disease with 2 of 4 patients showing clinical response (1 with persistently elevated C-reactive protein). A prospective study is needed to define its efficacy, safety, and placement in managing pediatric Crohn disease in the future.
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2016 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Long term effectiveness of RA-1, a standardized Ayurvedic medicine as a monotherapy and in combination with disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis
Conclusion RA-1 is safe and effective in the long term management of symptomatic active chronic RA. DMARDs and/or steroids can be used judiciously along with RA-1 to treat difficult disease/flares. Further studies are required to evaluate RA-1 in early RA. This paves way for research and application of integrative therapeutic approach in clinical medicine.
Source: Journal of Ayurveda and Integrative Medicine - March 10, 2018 Category: Complementary Medicine Source Type: research

Secondary Loss of Response to Infliximab in Pediatric Crohn Disease: Does It Matter How and When We Start?
Conclusion: Early use of infliximab in pediatric Crohn disease is associated with a decrease in secondary LOR. The type of concomitant immunomodulator used does not make a difference to LOR rates.
Source: Journal of Pediatric Gastroenterology and Nutrition - March 24, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Long term effectiveness of RA-1, a standardized Ayurvedic medicine as a monotherapy and in combination with disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis
ConclusionRA-1 is safe and effective in the long term management of symptomatic active chronic RA. DMARDs and/or steroids can be used judiciously along with RA-1 to treat difficult disease/flares. Further studies are required to evaluate RA-1 in early RA. This paves way for research and application of integrative therapeutic approach in clinical medicine.
Source: Journal of Ayurveda and Integrative Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research

Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup
ConclusionsWe have presented the recommendations concerning the use of RRTs for treatment of intoxications with toxic alcohols, lithium, vancomycin, theophylline, barbiturates, metformin, carbamazepine, methotrexate, phenytoin, acetaminophen, salicylates, valproic acid, and aminoglycosides.
Source: Pediatric Nephrology - October 15, 2019 Category: Urology & Nephrology Source Type: research