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Drug: Methotrexate

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Systemic Treatments in Pediatric Psoriasis: A Retrospective Single-Center Study
CONCLUSION: All treatments were effective and none of them was superior in terms of the healing period. Systemic treatments used in adults can also be used in pediatric patients with psoriasis with similar efficacy and safety rates as long as routine monitoring is provided.PMID:35014238 | DOI:10.34172/aim.2021.135
Source: Archives of Iranian Medicine - January 11, 2022 Category: Middle East Health Authors: Gokhan Sahin Fatma Aydin Esra Pancar Yuksel Source Type: research

Sequential use of hemoperfusion and single-pass albumin dialysis can safely reverse methotrexate nephrotoxicity
ConclusionCHP and SPAD are effective extracorporeal methods of removing methotrexate. They provide alternative treatment options for critical care nephrologists in the management of methotrexate toxicity.
Source: Pediatric Nephrology - August 25, 2016 Category: Urology & Nephrology Source Type: research

Evaluation and Management of Acute-Onset Hemiparesis in an Adolescent With Leukemia
We present a case of a 15-year-old boy with pre-B acute lymphoblastic leukemia on chemotherapy, having recently received a high-dose methotrexate infusion in addition to intrathecal methotrexate therapy, who presented to our ED with acute right-sided hemiparesis. He was initially suspected as having a possible ischemic stroke. Magnetic resonance imaging (diffusion-weighted and fluid-attenuated inversion recovery sequence) demonstrated focal areas of diffusion restriction, an early sign of delayed-onset methotrexate neurotoxicity. Our patient received appropriate supportive care and leucovorin rescue with gradual clinical r...
Source: Pediatric Emergency Care - March 1, 2018 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Practice Variations in the Management of Inflammatory Bowel Disease Between Pediatric and Adult Gastroenterologists
Conclusions: This study demonstrates that common practices in inflammatory bowel disease patients differ significantly between adult and pediatric practitioners. These findings call for investigating the reasons for these differences and promoting strategies to diminish these gaps.
Source: Journal of Pediatric Gastroenterology and Nutrition - February 25, 2016 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events
New England Journal of Medicine, Ahead of Print.
Source: New England Journal of Medicine - November 10, 2018 Category: Internal Medicine Authors: Paul M Ridker Brendan M. Everett Aruna Pradhan Jean G. MacFadyen Daniel H. Solomon Elaine Zaharris Virak Mam Ahmed Hasan Yves Rosenberg Erin Iturriaga Milan Gupta Michelle Tsigoulis Subodh Verma Michael Clearfield Peter Libby Samuel Z. Goldhaber Roger Sea Source Type: research

Concurrent Imatinib Dosing With High-dose Methotrexate Leads to Acute Kidney Injury and Delayed Methotrexate Clearance in Pediatric Patients With Philadelphia Chromosome-positive B-Cell Acute Lymphoblastic Leukemia
Imatinib, a tyrosine kinase inhibitor has improved survival in pediatric patients with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia. There are no formal drug interactions listed between methotrexate and tyrosine kinase inhibitors. Four pediatric patients with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia had delayed methotrexate clearance during their first cycle of high-dose methotrexate while receiving imatinib, resulting in acute kidney injury. For subsequent high-dose methotrexate cycles, imatinib was withheld resulting in decreased acute kidney injury, shorter time to met...
Source: Journal of Pediatric Hematology Oncology - February 25, 2021 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Improving the Prognosis of Pediatric Hodgkin Lymphoma in Developing Countries: A Moroccan Society of Pediatric Hematology and Oncology Study
ConclusionsGood outcomes for pediatric HL patients can be achieved in LMIC using a multidisciplinary team approach, uniform protocol‐based therapy, twinning partnership among oncology units in‐country and abroad, and a data collection system to monitor compliance and identify gaps in care. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - April 20, 2013 Category: Cancer & Oncology Authors: Laila Hessissen, Rachida Khtar, Abdellah Madani, Maria El Kababri, Amina Kili, Mhamed Harif, Mohamed Khattab, Souha Sahraoui, Nouredine Benjaafar, Samir Ahid, Scott C. Howard, Said Benchekroun Tags: Research Article Source Type: research

Allogeneic Matched Related Donor Bone Marrow Transplantation for Pediatric Patients With Severe Aplastic Anemia Using “Low-dose” Cyclophosphamide, ATG Plus Fludarabine
Conclusion: This small pilot study shows that this cytoreductive regimen could be considered as the standard of care for transplantation of pediatric patients with aplastic anemia from HLA-matched siblings.
Source: Journal of Pediatric Hematology Oncology - April 26, 2018 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

Oral Methods of Urinary Alkalinization for High-dose Methotrexate Administration: Alternatives to Intravenous Sodium Bicarbonate During a Critical Drug Shortage
A nationwide shortage of intravenous (IV) sodium bicarbonate required institutions to explore alternative options for urinary alkalinization for high-dose methotrexate (HDMTX). Children’s Hospital Colorado implemented a protocol utilizing oral alkalinizing agents as alternatives to intravenous sodium bicarbonate during the shortage. The purpose of this study was to determine the safety and efficacy of oral alkalinization strategies for HDMTX administration. This retrospective study was conducted at a pediatric institution and evaluated cycles of HDMTX administered with at least one dose of oral sodium bicarbonate tablets...
Source: Journal of Pediatric Hematology Oncology - June 26, 2019 Category: Hematology Tags: Original Articles Source Type: research

Targeted therapies for pediatric psoriasis.
Authors: Schwartz G, Paller AS Abstract Children who are recalcitrant to topical therapy for their moderate to severe plaque psoriasis and/or highly visible lesions may be candidates for systemic therapy. Methotrexate has been the most commonly used systemic agent in children. However, at least 25% of patients are now treated with biologics, especially tumor necrosis factor-α inhibitors, and their use is expanding as their availability, demonstrated safety and efficacy, and practitioner experience are increasing. In the United States, etanercept is Food and Drug Administration approved for ages 6 years and older a...
Source: Seminars in Cutaneous Medicine and Surgery - September 16, 2018 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Genetic polymorphisms of genes encoding drug metabolism are related to oral mucositis in pediatric patients with cancer
Objective: To investigate the incidence of oral mucositis (OM) in pediatric patients undergoing oncological treatment and their relationship with genetic polymorphisms of genes encoding chemotherapeutic drugs metabolism and transport. Study Design: DNA was isolated from whole blood of 89 pediatric patients with cancer who received treatment with methotrexate (MTX) and/or cyclophosphamide and/or doxorubicin. Next-generation sequencing (NGS) was performed using a customized panel of genes in the platform Ion Torrent PGM to analyze genetic polymorphisms of the ABCB1, ABCC2, and MTHFR genes.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 31, 2020 Category: ENT & OMF Authors: MARINA CURRA, AMANDA DE FARIAS GABRIEL, MARINA SIEBERT, ÚRSULA DA SILVEIRA MATTE, ANDRé BRUNETTO, LAURO JOSé GREGIANIN, MANOELA DOMINGUES MARTINS Tags: 20190819 Source Type: research

Imaging Chemotherapy-Induced Brain Damage in Pediatric Cancer Survivors
Conclusion: Our preliminary data show that PET/MRI can detect early signs of chemotherapy-induced brain damage. Since there is a window of time between drug exposure and morbidity, this early detection could enable non-invasive monitoring of interventions, which can improve clinical outcomes. Further evaluations are needed to confirm these data. Table 1: Brain regions, corresponding Brodmann areas, and related neurocognitive disorders.FunctionRegionBrodmann AreasExecutive FunctionPrefrontal cortex, Cingulum (region 1)9,10,11Intellectual (IQ)Dorsolateral Prefrontal Cortex (region 2)9,10,11AttentionAnterior insula (region 3)...
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Baratto, L., Lopez Garcia, D., Rashidi, A., Iv, M., Hawk, K. E., Daldrup-Link, H. Tags: Spotlight on Endocrinology and Pediatrics Source Type: research

Central hypothyroidism in a pediatric case of primary acute monoblastic leukemia with central nervous system infiltration: A case report
Rationale: Central nervous system (CNS) leukemia is a frequent diagnosis in pediatric acute myeloblastic leukemia (AML) and includes neural symptoms. However, CNS leukemia is rarely associated with central hypsothyroidism. Patient concerns and diagnoses: A 2-year-old female with AML with MLL rearrangement presented with CNS infiltration. Laboratory tests suggested the presence of central hypothyroidism (thyroid-stimulating hormone [TSH]: 0.48 mIU/ml, normal range 0.7–6.4 mIU/ml; serum free thyroxine [FT4]: 0.62 ng/dl, normal range 0.8–2.2 ng/dl; free triiodothyronine: 1.57 pg/ml, normal range 2.7–5.6 pg/ml). Magneti...
Source: Medicine - June 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Association between MTHFR microRNA binding site polymorphisms and methotrexate concentrations in Chinese pediatric patients with acute lymphoblastic leukemia
ConclusionsThe rs3737966 and rs35134728 polymorphisms in MTHFR were associated with serum MTX concentrations. The findings indicated miRNAs might be involved in the post‐transcriptional regulation of MTHFR.
Source: The Journal of Gene Medicine - October 9, 2017 Category: Genetics & Stem Cells Authors: Shu ‐mei Wang, Wei‐xin Zeng, Wan‐shui Wu, Lu‐lu Sun, Dan Yan Tags: RESEARCH ARTICLE Source Type: research