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Drug: Methotrexate

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Effect of an Extract from the Egyptian Sea Cucumber, Bohadschia marmorata, on Methotrexate-Induced Hepatorenal Toxicity in Male Mice
CONCLUSIONS: Biochemical analysis and histopathological examination of liver tissue showed that administration of MTX increased serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lowered levels of serum albumin, total protein, Superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Administration of B. marmorata extract to MTX- injected mice significantly reversed the increase in serum levels of liver enzymes and induced a significant elevation in serum albumin and total protein levels. SOD, CAT, and GSH levels returned to nearly normal levels. Histopathological examination indi...
Source: Cancer Control - February 28, 2022 Category: Cancer & Oncology Authors: Manar Kandeil Eman El-Sayed El-Nahass Mona Elwan Source Type: research

Effectiveness of anti-tnf therapy compared to immune modulator for prevention of surgical recurrence in pediatric cd
Crohn ’s disease (CD) is an immune-mediated, chronic inflammatory disease without a present cure. Surgical intervention for disease complications is common among CD patients, however post-operative strategies to prevent disease recurrence represent a critical knowledge gap, particularly in the pediatric CD population. Although adult CD data suggest effectiveness of anti-Tumor Necrosis Factor (TNF) therapies for prevention of recurrence, similar evidence is scarce for the pediatric population. We sought to evaluate the effectiveness of anti-TNF monotherapy compared to immune modulator (methotrexate or thiopurine) monother...
Source: Gastroenterology - January 20, 2022 Category: Gastroenterology Authors: Matthew Egberg, Xian Zhang, Michael Phillips, Michael Kappelman Tags: Comparative Effectiveness Studies Source Type: research

Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What We Have Learned On the Genetic Variants of Drug Transporters.
CONCLUSION: Overall, the data critically reviewed in this mini-review article confirmed that polymorphisms in the genes encoding SLC and ABC transporters confer higher sensitivity to altered plasma levels, MTX-induced toxicity, and therapeutic response in pediatric patients with ALL. Pre-emptive determination may be helpful in individualizing treatment. PMID: 30931851 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - March 28, 2019 Category: Drugs & Pharmacology Authors: Hu YH, Zhou L, Wang SS, Jing X, Guo HL, Sun F, Zhang Y, Chen F, Xu J, Ji X Tags: Curr Pharm Des Source Type: research

Busulfan, Cyclophosphamide and Melphalan As Conditioning Regimen for Pediatric Patients with AML in 1st or 2nd CR: A Retrospective Analysis from the AIEOP HSCT Registry
In conclusion, our results confirm the efficacy of BuCyMel in preventing relapse in a large series of pediatric patients affected by AML in CR1 and CR2. Adolescents represent a population of more fragile patients at risk of developing transplant-related fatalities. Optimization of toxicity profile and supportive care could further improve outcomes. Prospective randomized clinical trials are warranted to assess the best conditioning regimen for children and adolescents with AML.DisclosuresZecca: Chimerix: Honoraria. Locatelli: Bellicum: Consultancy, Membership on an entity's Board of Directors or advisory committees; bluebi...
Source: Blood - November 21, 2018 Category: Hematology Authors: Ruggeri, A., Zecca, M., Fagioli, F., Balduzzi, A., Algeri, M., Tumino, M., Ripaldi, M., Masetti, R., Saglio, F., Rovelli, A., Locatelli, F. Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster I Source Type: research

Chemotherapy intravenously in children with cancer at home, the nurse practitioner makes it possible!
ConclusionIt is feasible to administer intravenous chemotherapy at home in a safe and efficient way. The role of the specialized pediatric oncology nurse practitioner is an essential one.
Source: Supportive Care in Cancer - November 1, 2019 Category: Cancer & Oncology Source Type: research

What Causes Early Pregnancy Vaginal Bleeding?
Discussion Pregnancy complications in early pregnancy range from mild to severe. They can include nausea and emesis which often is treated symptomatically, but can cause hyperemesis gravidarum and need hospitalization for intravenous fluids. Mild cramping and slight spotting are not uncommon. Some type of pregnancy bleeding is common with 20-40% of women experiencing it. Women who have early vaginal bleeding have a higher risk of later pregnancy complications. Pregnancy in adolescents is about 10% of all pregnancies. Adolescent pregnancy can be associated with various problems including higher rates of threatened aborti...
Source: PediatricEducation.org - July 13, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Immunosuppression and immunization: Vaccination in pediatric patients with neuromuscular diseases treated with steroids or immune-modulating drugs
CONCLUSION: With just a few exceptions, vaccines are safe in this group of patients and they should receive the same immunizations and according to the same schedule, as all children. Live vaccines should not be administered in patients receiving high dose steroid or immune-modulating drugs such as anti-B cell treatments (rituximab), high dose methotrexate, azathioprine or 6-mercaptopurine. Whenever possible, all live vaccines should be administered prior to long term immune-suppressant treatments. Additional vaccines are recommended in this risk population of children (influenza, pneumococcal, varicella).PMID:34752936 | D...
Source: European Journal of Paediatric Neurology - November 9, 2021 Category: Neurology Authors: Tanja Golli Andrej Kastrin Marko Pokorn Zvonka Rener-Primec Source Type: research

Predictors of Chemotherapy Induced Adverse Events in Pediatric Osteosarcoma Patients
CONCLUSION: Major adverse events are becoming more common in pediatric osteosarcoma patients, and risk factors include larger chemotherapy doses, higher plasma methotrexate concentrations, and a slower pre-hydration rate. The outcomes of the study could aid in the better treatment of toxicity in children with osteosarcoma.PMID:35092376 | DOI:10.31557/APJCP.2022.23.1.93
Source: Asian Pacific Journal of Cancer Prevention - January 29, 2022 Category: Cancer & Oncology Authors: Phitjira Sanguanboonyaphong Patcharee Komvilaisak Kunanya Suwannaying Jukapun Yoodee Manit Saeteaw Suthan Chanthawong Suphat Subongkot Source Type: research