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Total 6421 results found since Jan 2013.

Sulphonylureas and risk of cardiovascular disease: systematic review and meta‐analysis
ConclusionsResults suggest that sulphonylurea use may elevate the risk of cardiovascular disease among patients with diabetes. This meta‐analysis expands the pool of studies evaluating cardiovascular mortality compared with prior observations while using adjusted estimates, and assessing an additional outcome of a composite cardiovascular event. This finding warrants consideration in clinical practice when other treatment options may be available.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - May 11, 2013 Category: Endocrinology Authors: O. J. Phung, E. Schwartzman, R. W. Allen, S. S. Engel, S. N. Rajpathak Tags: Review Source Type: research

Comparative Safety and Effectiveness of Metformin in Patients With Diabetes Mellitus and Heart Failure: Systematic Review of Observational Studies Involving 34 000 Patients Original Articles
Conclusions— The totality of evidence indicates that metformin is at least as safe as other glucose-lowering treatments in patients with diabetes mellitus and HF and even in those with reduced left ventricular ejection fraction or concomitant chronic kidney disease. Until trial data become available, metformin should be considered the treatment of choice for patients with diabetes mellitus and HF.
Source: Circulation: Heart Failure - May 21, 2013 Category: Cardiology Authors: Eurich, D. T., Weir, D. L., Majumdar, S. R., Tsuyuki, R. T., Johnson, J. A., Tjosvold, L., Vanderloo, S. E., McAlister, F. A. Tags: Congestive, Type 2 diabetes, Other Treatment Original Articles Source Type: research

The LITFL Review 104
Welcome to the 104th edition! The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peaks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the best and brightest from the blogosphere, the podcast video/audiosphere and the rest of the Web 2.0 social media jungle to find the most fantastic EM/CC FOAM (Free Open Access Meducation) around. The Most Fair Dinkum Ripper Beaut of the Week Emergency Physicians Monthly Top spot goes to Emergency Physicians Monthly with a thought provoking and awe inspiri...
Source: Life in the Fast Lane - May 21, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education eLearning Emergency Medicine Featured Health Intensive Care LITFL review LITFL R/V Source Type: blogs

Evaluating second-line treatment options for type 2 diabetes: focus on secondary effects of GLP-1 agonists and DPP-4 inhibitors.
CONCLUSIONS: Demonstrated secondary benefits in addition to efficacy may make GLP-1 agonists and DPP-4 inhibitors a more favorable option than other second-line T2DM therapies. PMID: 23548652 [PubMed - in process]
Source: The Annals of Pharmacotherapy - April 1, 2013 Category: Drugs & Pharmacology Authors: Boland CL, Degeeter M, Nuzum DS, Tzefos M Tags: Ann Pharmacother Source Type: research

Efficacy and safety of dipeptidyl peptidase‐4 inhibitors and metformin as initial combination therapy and as monotherapy in patients with type 2 diabetes mellitus: A Meta‐analysis
ConclusionsDPP‐4 inhibitors, which were safe and effective in controlling the blood glucose, may possibly decrease the risk of CV events in patients with T2DM. It could be a credible alternative for T2DM patients who, for some reason, cannot use metformin, or are in high risk of CV exposure. High‐quality, large sample and long‐term follow‐up clinical trails are needed to confirm the long‐term conclusions.
Source: Diabetes, Obesity and Metabolism - June 26, 2013 Category: Endocrinology Authors: Wu Dan, Li Ling, Liu Cong Tags: Original Paper Source Type: research

Efficacy and safety of initial combination of DPP‐IV inhibitors and metformin versus metformin monotherapy in type 2 diabetes: a systematic review of randomized controlled trials
ConclusionsCompared with equal‐dosage metformin monotherapy, the initial combination of metformin and DPP‐IV inhibitors were more effective in glycemic control without additional risk of adverse events, therefore it can be considered as a beneficial therapeutic regimen for drug‐naïve type 2 diabetes patients.
Source: Diabetes, Obesity and Metabolism - August 13, 2013 Category: Endocrinology Authors: Weiyi Gao, Jianjun Dong, Lin Liao, Ju Liu, Yan Li, Fupeng Liu, Liu Yang, Xiaojun Zhou Tags: Unsolicated review article Source Type: research

Correlates of Treatment Patterns among Youth with Type 2 Diabetes.
ConclusionsAbout half of youth with type 2 diabetes were managed with lifestyle or metformin alone, and had better glycemic control than individuals using other therapies. Those with longer diabetes duration in particular commonly experience treatment failures and more effective management strategies are needed. PMID: 24026554 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 11, 2013 Category: Endocrinology Authors: Badaru A, Klingensmith GJ, Dabelea D, Mayer-Davis EJ, Dolan L, Lawrence JM, Marcovina S, Beavers D, Rodriguez BL, Imperatore G, Pihoker C Tags: Diabetes Care Source Type: research

Medical Mispronunciations and Misspelled Words: The Definitive List.
Hearing medical mispronunciations and seeing misspelled words are an under appreciated  joy of working in healthcare.  Physicians often forget just how alien the language of medicine is to people who don't live it everyday.  The best part about being a physician is not helping people recover from critical illness. The best part is not  about  listening and understanding with compassion and empathy.  Nope, the best part about being a physician is hearing patients and other healthcare providers butcher the language of medicine and experiencing great entertainment in the process.   Doctors c...
Source: The Happy Hospitalist - October 2, 2013 Category: Internists and Doctors of Medicine Authors: Tamer Mahrous Source Type: blogs

Could exercise be as effective as medication?
Conclusion The researchers found that there are very few trials that directly compare exercise with drug therapy for any condition. They were only able to find enough trials to be able to analyse results for four major conditions. They found that exercise reduced death rates for people after a stroke (although this analysis has limitations and should be interpreted cautiously), and that drug therapy with diuretics improved death rates for people with heart failure. They did not find any difference between exercise and drug therapy for death rates after a heart attack or in people with pre-diabetes. There were several limit...
Source: NHS News Feed - October 2, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Medication Source Type: news

Obesity may be linked with slow metabolism for some
Conclusion This study has shown a link between rare changes in the KSR2 gene and severe childhood onset obesity. The changes seem to result in people eating more, particularly in childhood, and burning off calories less effectively. The authors say that their findings need to be confirmed in other studies. These findings suggest that this gene is playing a role in some people’s obesity. However, about 2% of the severely obese people assessed carried changes in this gene, compared with 1% in the general population. Therefore, the KSR2 gene is not responsible for all cases of obesity. In families with individuals carrying ...
Source: NHS News Feed - October 25, 2013 Category: Consumer Health News Tags: Genetics/stem cells Obesity Source Type: news

Effects of treatment with metformin on TSH levels: a meta-analysis of literature studies.
Conclusions.Metformin induces a reduction in TSH levels both in overt and in subclinical hypothyroidism. In contrast, no change in TSH levels is found in euthyroid patients. PMID: 24203069 [PubMed - as supplied by publisher]
Source: Diabetes Metab - November 7, 2013 Category: Endocrinology Authors: Lupoli R, Di Minno A, Tortora A, Ambrosino P, Arianna Lupoli G, Di Minno MN Tags: J Clin Endocrinol Metab Source Type: research

Systematic review with meta‐analysis: non‐alcoholic steatohepatitis ‐ a case for personalised treatment based on pathogenic targets
ConclusionsCurrently, there are few options available for the management of NASH. Future targeted treatment strategies based on the pathogenic pathways may be needed to develop effective treatment for patients with NASH.
Source: Alimentary Pharmacology and Therapeutics - November 10, 2013 Category: Drugs & Pharmacology Authors: Z. M. Younossi, M. J. Reyes, A. Mishra, R. Mehta, L. Henry Tags: Systematic Review with Meta‐Analysis Source Type: research

The prognostic value of metformin for cancer patients with concurrent diabetes‐ a systematic review and meta‐analysis
ConclusionsThe findings of the present study support the hypothesis that metformin improves the survival for cancer patients with concurrent diabetes, particularly for ovarian, pancreatic and colorectal, and endometrial cancer. Further investigation is warranted.
Source: Diabetes, Obesity and Metabolism - January 27, 2014 Category: Endocrinology Authors: Zhi‐Jiang Zhang, Shiyue Li Tags: Research Article Source Type: research

The prognostic value of metformin for cancer patients with concurrent diabetes- a systematic review and meta-analysis.
CONCLUSIONS: The findings of the present study support the hypothesis that metformin improves the survival for cancer patients with concurrent diabetes, particularly for ovarian, pancreatic and colorectal, and endometrial cancer. Further investigation is warranted. PMID: 24460896 [PubMed - as supplied by publisher]
Source: Diabetes Metab - January 27, 2014 Category: Endocrinology Authors: Zhang ZJ, Li S Tags: Diabetes Obes Metab Source Type: research