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Drug: Taxotere
Therapy: Cancer Therapy
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Total 74 results found since Jan 2013.
New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & amp; therapeutics
Front Oncol. 2023 Aug 17;13:1193736. doi: 10.3389/fonc.2023.1193736. eCollection 2023.ABSTRACTProstate adenocarcinoma accounts for more than 20% of deaths among males due to cancer. It is the fifth-leading cancer diagnosed in males across the globe. The mortality rate is quite high due to prostate cancer. Despite the fact that advancements in diagnostics and therapeutics have been made, there is a lack of effective drugs. Metabolic pathways are altered due to the triggering of androgen receptor (AR) signaling pathways, and elevated levels of dihydrotestosterone are produced due to defects in AR signaling that accelerate th...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Neha Thakur Sameer Quazi Bindu Naik Saurabh Kumar Jha Pallavi Singh Source Type: research
Comparison of PLLA-PEG and PDLLA-PEG micelles for co-encapsulation of docetaxel and resveratrol
This article presents a comparison of single- (Dtx or Res) and dual-drug (Dtx and Res) loaded micelles obtained from poly(l,l-lactide)-co-poly(ethylene glycol) (PLLA-PEG) and poly(d,l-lactide)-co-poly(ethylene glycol) (PDLLA-PEG). The analyzes of the micelles have been conducted including morphology, drug(s) encapsulation efficiency, intermolecular interactions, in vitro drug release, and cytotoxicity. Differences in drug loading ability and release profile have been observed between Res and Dtx but also depending on the polymer and number of drugs in micelles (single vs. dual loaded). The PLLA-PEG micelles have a signific...
Source: Biomed Res - August 31, 2023 Category: Research Authors: Magdalena Jurczyk Monika Musia ł-Kulik Aleksander Fory ś Marcin Godzierz Bo żena Kaczmarczyk Janusz Kasperczyk Dorota Wrze śniok Artur Beberok Katarzyna Jelonek Source Type: research
Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies
ConclusionIn male rodents, melatonin therapy was related to improved testicular histopathology, reproductive hormones, testis and body weights, and reduced levels of oxidative markers in testicular tissues of male rodents. Future meticulous studies are recommended to provide a robust scientific backbone for human applications.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022355293, identifier CRD42022355293.
Source: Frontiers in Endocrinology - August 28, 2023 Category: Endocrinology Source Type: research
< em > CYP3A < /em > genetic variation and taxane-induced peripheral neuropathy: a systematic review, meta-analysis, and candidate gene study
Front Pharmacol. 2023 Jul 4;14:1178421. doi: 10.3389/fphar.2023.1178421. eCollection 2023.ABSTRACTBackground: Taxane-induced peripheral neuropathy (TIPN) is an important cause of premature treatment cessation and dose-limitation in cancer therapy. It also reduces quality of life and survivorship in affected patients. Genetic polymorphisms in the CYP3A family have been investigated but the findings have been inconsistent and contradictory. Methods: A systematic review identified 12 pharmacogenetic studies investigating genetic variation in CYP3A4*22 and CYP3A5*3 and TIPN. In our candidate gene study, 288 eligible participan...
Source: Cancer Control - July 20, 2023 Category: Cancer & Oncology Authors: Laurence McEvoy Joanne Cliff Daniel F Carr Andrea Jorgensen Rosemary Lord Munir Pirmohamed Source Type: research
Dual receptor specific nanoparticles targeting EGFR and PD-L1 for enhanced delivery of docetaxel in cancer therapy
Biomed Pharmacother. 2023 Jun 15;165:115023. doi: 10.1016/j.biopha.2023.115023. Online ahead of print.ABSTRACTDual-receptor targeted (DRT) nanoparticles which contain two distinct targeting agents may exhibit higher cell selectivity, cellular uptake, and cytotoxicity toward cancer cells than single-ligand targeted nanoparticle systems without additional functionality. The purpose of this study is to prepare DRT poly(lactic-co-glycolic acid) (PLGA) nanoparticles for targeting the delivery of docetaxel (DTX) to the EGFR and PD-L1 receptor positive cancer cells such as human glioblastoma multiform (U87-MG) and human non-small...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 17, 2023 Category: Drugs & Pharmacology Authors: Fakhrossadat Emami Ramesh Duwa Asmita Banstola Seon Min Woo Taeg Kyu Kwon Simmyung Yook Source Type: research
Identification of cardiotoxicity related to non-small cell lung cancer (NSCLC) treatments: A systematic review
Conclusion: The findings of this systematic review have provided a better understanding of the possible association between cardiotoxicities and anticancer drugs for NSCLC. Whilst variation is observed across different drug classes, the lack of information available on cardiac monitoring can result in underestimation of this association.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020191760, identifier PROSPERO CRD42020191760.
Source: Frontiers in Pharmacology - June 13, 2023 Category: Drugs & Pharmacology Source Type: research
Design, development, and in-vitro/in-vivo evaluation of Docetaxel-loaded PEGylated Solid Lipid Nanoparticles in Prostate Cancer Therapy
Eur J Pharm Biopharm. 2023 Jun 1:S0939-6411(23)00142-X. doi: 10.1016/j.ejpb.2023.05.020. Online ahead of print.ABSTRACTDocetaxel (DOC) is a potent anticancer molecule widely used to treat various cancers. However, its therapeutic efficacy as a potential anticancer agent has been limited owing to poor aqueous solubility, short circulation time, rapid reticuloendothelial system uptake, and high renal clearance, which consecutively showed poor bioavailability. In the present investigation, we developed polyethylene glycol (PEG) decorated solid lipid nanoparticles (SLN) using the solvent diffusion method to increase the biopha...
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 3, 2023 Category: Drugs & Pharmacology Authors: Swati Korake C Bothiraja Atmaram Pawar Source Type: research
Quality of life with docetaxel plus cisplatin versus paclitaxel plus carboplatin in patients with completely resected non-small cell lung cancer: quality of life analysis of TORG 0503
CONCLUSION: Total QOL was maintained better in the DC group than in the PC group, especially the taxane subscale that consists of neurotoxicity and taxane components in spite of no treatment-related death in both arms between DC and PC. We might recommend DC as the control regimen for the next clinical trial from the viewpoint of QOL, similar to the primary outcomes in TORG0503.PMID:37126140 | DOI:10.1007/s11136-023-03424-y
Source: Cell Research - May 1, 2023 Category: Cytology Authors: Ayako Matsuda Kazue Yamaoka Hideo Kunitoh Takashi Seto Masahiro Tsuboi Tatsuo Ohira Riichiroh Maruyama Hiroaki Okamoto Kaoru Kubota Source Type: research
