Filtered By:
Specialty: Biochemistry
Drug: Taxotere
This page shows you your search results in order of date.
Order by Relevance | Date
Total 89 results found since Jan 2013.
Targeting prostate cancer with docetaxel-loaded peptide 563-conjugated PEtOx-co-PEI < sub > 30% < /sub > -b-PCL polymeric micelle nanocarriers
Amino Acids. 2023 Jun 15. doi: 10.1007/s00726-023-03292-3. Online ahead of print.ABSTRACTProstate cancer is a global disease that negatively affects the quality of life. Although various strategies against prostate cancer have been developed, only a few achieved tumor-specific targeting. Therefore, a special emphasis has been placed on the treatment of cancer using nano-carrier-encapsulated chemotherapeutic agents conjugated with tumor-homing peptides. The targeting strategy coupling the drugs with nanotechnology helps to overcome the most common barriers, such as high toxicity and side effects. Prostate-specific membrane ...
Source: Amino Acids - June 15, 2023 Category: Biochemistry Authors: Ayca Ece Nezir Zeynep Busra Bolat Naile Ozturk Polen Kocak Ebru Zemheri Sevgi Gulyuz Umut Ugur Ozkose Ozgur Yilmaz Imran Vural Asuman Bozk ır Fikrettin Sahin Dilek Telci Source Type: research
Nanoencapsulation of Docetaxel Induces Concurrent Apoptosis and Necroptosis in Human Oral Cancer Cells (SCC-9) via TNF- α/RIP1/RIP3 Pathway
Indian J Clin Biochem. 2023 Jul;38(3):351-360. doi: 10.1007/s12291-022-01055-7. Epub 2022 Aug 9.ABSTRACTHuman oral squamous cell carcinoma is the sixth most frequent malignant cancer, with an unacceptably high death rate that affects people's health. Albeit, there are several clinical approaches for diagnosing and treating oral cancer they are still far from ideal. We previously synthesised and characterised the docetaxel nanoformulation (PLGA-Dtx) and discovered that docetaxel nanoencapsulation may suppress oral cancer cells. The goal of this study was to figure out the mechanism involved in the suppression of oral cancer...
Source: Clinical Biochemistry - May 26, 2023 Category: Biochemistry Authors: Parul Gupta Arpita Singh Ajay Kumar Verma Surya Kant Anuj Kumar Pandey Anupam Mishra Puneet Khare Ved Prakash Source Type: research
Engineered Microencapsulated Lactoferrin Nanoconjugates for Oral Targeted Treatment of Colon Cancer
This study provides the proof of concept for using NIMDs to enhance the effect of protein NPs in CRC treatment.PMID:37039769 | DOI:10.1021/acs.biomac.3c00037
Source: Biomacromolecules - April 11, 2023 Category: Biochemistry Authors: Yomna M Elmorshedy Mohamed Teleb Marwa A Sallam Kadria A Elkhodairy Mohammed Bahey-El-Din Doaa A Ghareeb Shaymaa A Abdulmalek Shimaa A H Abdel Monaim Adnan A Bekhit Ahmed O Elzoghby Fernando Albericio Sherine N Khattab Source Type: research
Sympathetic β < sub > 2 < /sub > -adrenergic receptor blockade overcomes docetaxel resistance in prostate cancer
CONCLUSION: Our data demonstrate that β2-AR inhibitor-induced autophagy and apoptosis contribute to the effectiveness responses to docetaxel in castration-resistant prostate cancer, and in combination with pharmacological agents of β2-AR and autophagy inhibitors may provide a potential therapeutic strategy to enhance the limited capacity of docetaxel to control castration-resistant prostate cancer.PMID:36989842 | DOI:10.1016/j.bbrc.2023.03.046
Source: Biochemical and Biophysical Research communications - March 29, 2023 Category: Biochemistry Authors: Mi Zhang Fangfang Chen Xueqing Sun Yanping Huang Yan Zeng Jinying Chen Shiqi Wu Chen Xu Source Type: research
KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation
In this study, we used docetaxel-resistant cell lines DU145/DTX50 and PC-3/DTX30 to measure the responses to cabazitaxel. Our findings demonstrated that docetaxel resistance could lead to cross-resistance to cabazitaxel. After docetaxel-resistant cells were treated with cabazitaxel, transcriptome analysis was performed, and the results were analyzed in combination with survival analysis and correlation analysis with Gleason score to screen the cross-resistance genes. The continuously increased expression of kinesin family member 14 (KIF14) was identified as the main cause of cross-resistance to cabazitaxel in docetaxel-res...
Source: Archives of Biochemistry and Biophysics - February 23, 2023 Category: Biochemistry Authors: Lina Liu Mengyuan Li Junshuo Zhang Dengfei Xu Yan Guo Hui Zhang Shundong Cang Source Type: research
Self-assembled nanocomposites of carboxymethyl β-dextran/protamine sulfate for enhanced chemotherapeutic drug sensitivity of triple-negative breast cancer by autophagy inhibition via a ternary collaborative strategy
In this study, a tri-drug nanocomposite (NP) delivery system was devised using carboxymethyl β-dextran (CMD) and protamine sulfate (PS), two natural materials with good bio-compatibility. They were designed to carry the chemotherapeutic drug docetaxel (DTX), the autophagy inhibitor chloroquine (CQ), and Atg5 siRNA to cancer cells. The CQ + DTX + Atg5 siRNA NPs was driven by electrostatic interaction and self-assembly methods. The breast cancer cell line MDA-MB-231 was used for both cell culture and establishing mouse xenograft model. Our findings demonstrated that CQ and Atg5 siRNA encapsulated in NPs could enhance the se...
Source: International Journal of Biological Macromolecules - February 13, 2023 Category: Biochemistry Authors: Yunhao Li Fan Jia Yujuan Gao Xuan Wang Xinyue Cui Zian Pan Weifeng Wang Mingjun Li Jianqing Lu Yan Wu Source Type: research
Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel
Biomacromolecules. 2023 Feb 13. doi: 10.1021/acs.biomac.2c01329. Online ahead of print.ABSTRACTCationic glycopolymers stand out as gene delivery nanosystems due to their inherent biocompatibility and high binding affinity to the asialoglycoprotein receptor (ASGPR), a target receptor overexpressed in hepatocellular carcinoma (HCC) cells. However, their synthesis procedure remains laborious and complex, with problems of solubilization and the need for protection/deprotection steps. Here, a mini-library of well-defined poly(2-aminoethyl methacrylate hydrochloride-co-poly(2-lactobionamidoethyl methacrylate) (PAMA-co-PLAMA) gly...
Source: Biomacromolecules - February 13, 2023 Category: Biochemistry Authors: Daniela Santo Rosemeyre A Cordeiro Patr ícia V Mendonça Arm énio C Serra Jorge F J Coelho Henrique Faneca Source Type: research
Ethoxysanguinarine induces apoptosis, inhibits metastasis and sensitizes cells to docetaxel in breast cancer cells through inhibition of Hakai
In this study, we investigated the anti-breast cancer effect of ESG and its underlying mechanism. MTT assay and flow cytometry analysis showed that ESG inhibited the viability and induced apoptosis in MCF7 and MDA-MB-231 human breast cancer cells. Western blot revealed that ESG triggered intrinsic and extrinsic apoptotic pathways, as evidenced by the activation of caspase-8, caspase-9 and caspase-3. ESG attenuated breast cancer cell migration and invasion through Hakai/E-cadherin/N-cadherin. Moreover, Hakai knockdown sensitized ESG-triggered viability and motility inhibition, suggesting that Hakai mediated the anti-breast ...
Source: Chemistry and Biodiversity - January 12, 2023 Category: Biochemistry Authors: Liang Ma Xiao-Jing Xuan Xue-Ming Chen Ming-Hui Fan Jian Liu Guozheng Huang Zi Liu Source Type: research
