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Drug: Restasis
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Total 1092 results found since Jan 2013.
Dual action of macrophage miR-204 confines cyclosporine A-induced atherosclerosis
Conclusion and implications Macrophage miR-204 ameliorates CsA-induced atherosclerosis, suggesting that miR-204 may be a potential target for the prevention and treatment of CsA-related atherosclerotic side effects.PMID:37702564 | DOI:10.1111/bph.16240
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Jia-Hui Su Yu Hong Cong-Cong Han Jie Yu Xin Guan Ya-Mei Zhu Cheng Wang Ming-Ming Ma Rui-Ping Pang Jing-Song Ou Jia-Guo Zhou Zi-Yi Zhang Tao Ban Si-Jia Liang Source Type: research
Brain α2δ-1-Bound NMDA Receptors Drive Calcineurin Inhibitor-Induced Hypertension
CONCLUSIONS: These findings indicate that α2δ-1 is essential for calcineurin inhibitor-induced increases in synaptic NMDAR activity in PVN presympathetic neurons and sympathetic outflow. Thus, α2δ-1 and α2δ-1-bound NMDARs represent new targets for treating calcineurin inhibitor-induced hypertension.PMID:37605933 | DOI:10.1161/CIRCRESAHA.123.322562
Source: Circulation Research - August 22, 2023 Category: Cardiology Authors: Jing-Jing Zhou Jian-Ying Shao Shao-Rui Chen Hui-Lin Pan Source Type: research
Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa
CONCLUSIONS: Transgenic hESCs differentiate into hRPE cells and retain sCX3CL1 transgene expression both in vitro and in vivo. Moreover, hRPE cells delivered to the subretinal space of rd10 mice prevented photoreceptor degeneration in a local-acting manner, suggesting that this approach could have applications for preserving photoreceptors in specific subregions of the retina, such as the macula. Overall, our study not only reveals the potential of a combined cell and gene therapy for the treatment of RP, but also the possibility of using hRPE cells to deliver therapeutic biologics in situ to treat diseases over long-term....
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Eric D Jong Sabiha Hacibekiroglu Lily Guo Evan Sawula Biao Li Chengjin Li Margaret T Ho Molly S Shoichet Valerie A Wallace Andras Nagy Source Type: research
Brain α2δ-1-Bound NMDA Receptors Drive Calcineurin Inhibitor-Induced Hypertension
CONCLUSIONS: These findings indicate that α2δ-1 is essential for calcineurin inhibitor-induced increases in synaptic NMDAR activity in PVN presympathetic neurons and sympathetic outflow. Thus, α2δ-1 and α2δ-1-bound NMDARs represent new targets for treating calcineurin inhibitor-induced hypertension.PMID:37605933 | DOI:10.1161/CIRCRESAHA.123.322562
Source: Circulation Research - August 22, 2023 Category: Cardiology Authors: Jing-Jing Zhou Jian-Ying Shao Shao-Rui Chen Hui-Lin Pan Source Type: research
Genes, Vol. 14, Pages 1655: PSTPIP1-Associated Myeloid-Related Proteinemia Inflammatory (PAMI) Syndrome: A Systematic Review
heodoropoulou
PSTPIP1 (proline-serine-threonine phosphatase-interactive protein 1)-associated myeloid-related proteinemia inflammatory (PAMI) syndrome, previously known as Hyperzincemia/Hypercalprotectinemia (Hz/Hc) syndrome, is a recently described, rare auto-inflammatory disorder caused by specific deleterious variants in the PSTPIP1 gene (p.E250K and p.E257K). The disease is characterized by chronic systemic inflammation, cutaneous and osteoarticular manifestations, hepatosplenomegaly, anemia, and neutropenia. Increased blood levels of MRP 8/14 and zinc distinguish this condition from other PSTPIP1-associated inflam...
Source: Genes - August 19, 2023 Category: Genetics & Stem Cells Authors: Manel Mejbri Raffaele Renella Fabio Candotti Cecile Jaques Dirk Holzinger Michael Hofer Katerina Theodoropoulou Tags: Systematic Review Source Type: research
Immunosuppressive therapy and oral anticoagulation in kidney transplant recipients: Direct oral anticoagulants versus vitamin-k antagonists
CONCLUSION: DOACs have similar safety and efficacy than AVK among KTRs treated with ISDs. However, careful evaluation of potential drug interaction and ISDs serum levels is needed.PMID:37573220 | DOI:10.1016/j.ejim.2023.08.003
Source: European Journal of Internal Medicine - August 12, 2023 Category: Internal Medicine Authors: Francesco Santoro Annalisa Casanova Simona Simone Carlo Alfieri Adele Falcone Andrea Dello Strologo Valeria Grandinetti Marco Busutti Giorgia Comai Tommaso Maria Marvulli Maria Grazia Zippo Giuseppe Castellano Gaetano La Manna Loreto Gesualdo Grandaliano Source Type: research
Subcutaneous panniculitis-like T-cell lymphoma in two unrelated individuals with BENTA disease
Clin Immunol. 2023 Aug 8:109732. doi: 10.1016/j.clim.2023.109732. Online ahead of print.ABSTRACTSubcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous non-Hodgkin lymphoma involving CD8+ T cells, the genetic underpinnings of which remain incompletely understood. Here we report two unrelated patients with B cell Expansion with NF-κB and T cell Anergy (BENTA) disease and a novel presentation of SPTCL. Patient 1 presented early in life with recurrent infections and B cell lymphocytosis, linked to a novel gain-of-function (GOF) CARD11 mutation (p.Lys238del). He developed SPTCL-like lesions and memb...
Source: Clinical Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Bradly M Bauman Batsukh Dorjbal Stefania Pittaluga Yu Zhang Julie E Niemela Jennifer L Stoddard Sergio D Rosenzweig Ronald Anderson Gregory M T Guilcher Iwona Auer Renee Perrier Martin Campbell Samarjeet K Bhandal Camille Alba Gautham Sukumar Clifton L Da Source Type: research
The reconstitution of T-cells after Allogeneic Hematopoietic Stem Cell Transplant in a Pediatric Patient with Congenital Amegakaryocytic Thrombocytopenia (CAMT)
CONCLUSION: Successful treatment of acute GvHD prevented advancing the condition to chronic GvHD, and this was accompanied by delayed T-cell reconstitution through an increase in Treg:Tcons ratio.PMID:37526450 | DOI:10.2174/1871530323666230801100113
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 1, 2023 Category: Endocrinology Authors: Shideh Namazi Bayegi Amir Ali Hamidieh Maryam Behfar Amene Saghazadeh Mahmood Bozorgmehr Nader Tajik Ali Akbar Delbandi Samaneh Delavari Mehdi Shekarabi Nima Rezaei Source Type: research
