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Total 71 results found since Jan 2013.
Impact of Arterial Access Site on Outcomes After Primary Percutaneous Coronary Intervention: Prespecified Subgroup Analysis From the EUROMAX Trial Coronary Interventions
Conclusions—
In this prespecified analysis from EUROMAX, radial access was preferred in lower risk patients and did not improve clinical outcomes. Bivalirudin was associated with less bleeding irrespective of access site.
Clinical Trial Registration—
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01087723.
Source: Circulation: Cardiovascular Interventions - June 8, 2015 Category: Cardiology Authors: Hamon, M., Coste, P., van't Hof, A., Ten Berg, J., Clemmensen, P., Tabone, X., Benamer, H., Kristensen, S. D., Cavallini, C., Marzocchi, A., Hamm, C., Kanic, V., Bernstein, D., Anthopoulos, P., Deliargyris, E. N., Steg, P. G. Tags: Cardiovascular Pharmacology, Catheter-based coronary and valvular interventions: other, Acute myocardial infarction Coronary Interventions Source Type: research
TCT: Structural Heart Disease and PFO Closure TrialsTCT: Structural Heart Disease and PFO Closure Trials
Drs Harrington and Bhatt discuss whether transcatheter aortic valve therapy is evolving naturally or moving beyond the evidence, bivalirudin in TAVR, and PFO closure for stroke prevention. theheart.org on Medscape
Source: theHeart.org - October 19, 2015 Category: Cardiology Tags: Cardiology Commentary Source Type: news
Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial
Publication date: Available online 5 November 2015 Source:The Lancet Author(s): A Michael Lincoff, Roxana Mehran, Thomas J Povsic, Steven L Zelenkofske, Zhen Huang, Paul W Armstrong, P Gabriel Steg, Christoph Bode, Mauricio G Cohen, Christopher Buller, Peep Laanmets, Marco Valgimigli, Toomas Marandi, Viliam Fridrich, Warren J Cantor, Bela Merkely, Jose Lopez-Sendon, Jan H Cornel, Jaroslaw D Kasprzak, Michael Aschermann, Victor Guetta, Joao Morais, Peter R Sinnaeve, Kurt Huber, Rod Stables, Mary Ann Sellers, Marilyn Borgman, Lauren Glenn, Arnold I Levinson, Renato D Lopes, Vic Hasselblad, Ri...
Source: The Lancet - November 6, 2015 Category: Journals (General) Source Type: research
Bivalirudin Versus Heparin Anticoagulation in Transcatheter Aortic Valve Replacement The Randomized BRAVO-3 Trial
BackgroundAnticoagulation is required during transcatheter aortic valve replacement (TAVR) procedures. Although an optimal regimen has not been determined, heparin is mainly used. Direct thrombin inhibition with bivalirudin may be an effective alternative to heparin as the procedural anticoagulant agent in this setting.ObjectivesThe goal of this study was to determine whether bivalirudin offers an alternative to heparin as the procedural anticoagulant agent in patients undergoing TAVR.MethodsA total of 802 patients with aortic stenosis were randomized to undergo transfemoral TAVR with bivalirudin versus unfractionated hepa...
Source: Journal of the American College of Cardiology - December 21, 2015 Category: Cardiology Source Type: research
Bivalirudin Is Associated With Improved In-Hospital Outcomes Compared With Heparin in Percutaneous Vascular Interventions: Observational, Propensity-Matched Analysis From the Premier Hospital Database Peripheral Vascular Disease
Conclusions—
In patients undergoing peripheral vascular interventions, procedural anticoagulation with bivalirudin may result in more favorable in-hospital outcomes compared with unfractionated heparin, the current standard of care. These observations will require prospective confirmation in a randomized, controlled trial.
Source: Circulation: Cardiovascular Interventions - January 8, 2016 Category: Cardiology Authors: Kimmelstiel, C., Pinto, D., Aronow, H. D., Weintraub, A. R., Dangas, G., Fan, W., Prats, J., Deliargyris, E. N., Katzen, B. T. Tags: Anticoagulants, Pharmacology, Peripheral Vascular Disease, Vascular Disease Source Type: research
Sex‐Based Differences In Outcomes With Bivalirudin Or Unfractionated Heparin For Transcatheter Aortic Valve Replacement: Results From The BRAVO 3 Randomized Trial
Conclusions: There was no difference in early outcomes with bivalirudin versus UFH in men or women undergoing contemporary TAVR. This article is protected by copyright. All rights reserved.
Source: Catheterization and Cardiovascular Interventions - April 30, 2016 Category: Cardiovascular & Thoracic Surgery Authors: A Asgar, J Chandrasekhar, G Mikhail, J Webb, T Lefevre, C Tamburino, D Hildick‐Smith, R Hambrecht, E Van Belle, J Widder, N Dumonteil, U Hink, R Jeger, A Linke, E Dellargyris, P Gao, R Mehran, C Hengstenberg, P Anthopoulos, G Dangas, Tags: Original Studies Source Type: research
Sex ‐Based Differences In Outcomes With Bivalirudin Or Unfractionated Heparin For Transcatheter Aortic Valve Replacement: Results From The BRAVO 3 Randomized Trial
Conclusions: There was no difference in early outcomes with bivalirudin versus UFH in men or women undergoing contemporary TAVR. This article is protected by copyright. All rights reserved.
Source: Catheterization and Cardiovascular Interventions - June 30, 2016 Category: Cardiovascular & Thoracic Surgery Authors: A Asgar, J Chandrasekhar, G Mikhail, J Webb, T Lefevre, C Tamburino, D Hildick ‐Smith, R Hambrecht, E Van Belle, J Widder, N Dumonteil, U Hink, R Jeger, A Linke, E Dellargyris, P Gao, R Mehran, C Hengstenberg, P Anthopoulos, G Dangas, Tags: Original Studies Source Type: research
Cerebral Embolism During Transcatheter Aortic Valve Replacement The BRAVO-3 MRI Study
ConclusionsThis study documented cerebral embolization in nearly two-thirds of patients during contemporary TAVR. There were no significant differences in cerebral embolization for bivalirudin versus heparin anticoagulation during TAVR. (Open-Label, Randomized Trial in Patients Undergoing TAVR to Determine Safety and Efficacy of Bivalrudin vs. UFH [BRAVO-2/3]; NCT01651780)
Source: Journal of the American College of Cardiology - August 2, 2016 Category: Cardiology Source Type: research
Efficacy and safety of prehospital administration of unfractionated heparin, enoxaparin or bivalirudin in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Insights from the ORBI registry.
CONCLUSION: In this prospective registry, there were no significant differences in the rates of in-hospital MACE or major bleeding after prehospital initiation of UFH, enoxaparin or bivalirudin in patients treated by primary PCI for STEMI.
PMID: 27818120 [PubMed - as supplied by publisher]
Source: Archives of Cardiovascular Diseases - November 2, 2016 Category: Cardiology Authors: Auffret V, Leurent G, Boulmier D, Bedossa M, Zabalawi A, Hacot JP, Coudert I, Filippi E, Castellant P, Rialan A, Rouault G, Druelles P, Boulanger B, Treuil J, Avez B, Le Guellec M, Gilard M, Le Breton H Tags: Arch Cardiovasc Dis Source Type: research
Unfractionated heparin versus bivalirudin in patients undergoing primary percutaneous coronary intervention: a SWEDEHEART study.
CONCLUSIONS: In this large, nationwide observational study we found low and similar rates of early ST in UFH only and bivalirudin treated patients undergoing primary PCI. Mortality was higher in UFH compared with bivalirudin treated patients.
PMID: 28044990 [PubMed - as supplied by publisher]
Source: EuroIntervention - January 5, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Effect of Post ‐procedural Full Does Infusion of Bivalirudin on Acute Stent Thrombosis in Patients with ST‐elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Outcomes in a large real‐world population
ConclusionPost‐PCI full‐does bivalirudin infusion is safe and has a trend to protect against acute ST in STEMI patients undergoing primary PCI in real world settings.This article is protected by copyright. All rights reserved.
Source: Cardiovascular Therapeutics - January 13, 2017 Category: Cardiology Authors: Heyang Wang, Zhenyang Liang, Yi Li, Bin Li, Junming Liu, Xueyi Hong, Xin Lu, Jiansheng Wu, Wei Zhao, Qiang Liu, Jian An, Linfeng Li, Fanli Pu, Qiang Ming, Yaling Han Tags: Original Research Article Source Type: research
Comparison of antithrombotic agents during urgent percutaneous coronary intervention following thrombolytic therapy: A retrospective cohort study
ConclusionIn STEMI patients undergoing PCI within 24 hr after thrombolytic therapy, bivalirudin was associated with a strong trend toward reduced bleeding complications as compared to heparin alone or heparin plus GPI.The optimal antithrombotic regiment for urgent PCI following thrombolytic therapy is currently unknown. Our study demonstrated that use of bivalirudin during PCI following thrombolytic therapy is associated with a trend toward reduced bleeding complications compared to heparin alone or heparin plus GPI. Large randomized trials of adjunctive anticoagulation during PCI in this complex post‐thrombolytic popula...
Source: Catheterization and Cardiovascular Interventions - April 18, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Jaya R. Mallidi, Peter Robinson, Paul F. Visintainer, Amir S. Lotfi, Scott Mulvey, Gregory R. Giugliano Tags: Coronary Artery Disease Source Type: research
Analysis shows increased risk of early stroke with new-onset atrial fibrillation post-TAVR
(Society for Cardiovascular Angiography and Interventions) Results from 'Effect of bivalirudin versus unfractionated heparin in patients with baseline or new-onset atrial fibrillation in transcatheter aortic valve replacement: From the BRAVO-3 randomized trial' were presented today as a late-breaking clinical trial at the Society for Cardiovascular Angiography and Interventions (SCAI) 2017 Scientific Sessions in New Orleans.
Source: EurekAlert! - Social and Behavioral Science - May 11, 2017 Category: International Medicine & Public Health Source Type: news
Effect of postprocedural full ‐dose infusion of bivalirudin on acute stent thrombosis in patients with ST‐elevation myocardial infarction undergoing primary percutaneous coronary intervention: Outcomes in a large real‐world population
ConclusionPost‐PCI full‐dose bivalirudin infusion is safe and has a trend to protect against acute ST in STEMI patients undergoing primary PCI in real‐world settings.
Source: Cardiovascular Therapeutics - May 12, 2017 Category: Cardiology Authors: Heyang Wang, Zhenyang Liang, Yi Li, Bin Li, Junming Liu, Xueyi Hong, Xin Lu, Jiansheng Wu, Wei Zhao, Qiang Liu, Jian An, Linfeng Li, Fanli Pu, Qiang Ming, Yaling Han Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
No difference in rate of adverse cardiovascular events when comparing anticoagulants
In patients undergoing transradial primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI), there was no significant difference in the rate of a composite of death, myocardial infarction and stroke whether they were anticoagulated with bivalirudin or unfractioned heparin, according to a study.
Source: ScienceDaily Headlines - May 17, 2017 Category: Science Source Type: news
