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Drug: Acetylcysteine
Procedure: Gastroschisis Repair
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Total 24 results found since Jan 2013.
Copper metabolism in cell death and autophagy
Autophagy. 2023 Apr 16:1-21. doi: 10.1080/15548627.2023.2200554. Online ahead of print.ABSTRACTCopper is an essential trace element in biological systems, maintaining the activity of enzymes and the function of transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as apoptosis, paraptosis, pyroptosis, ferroptosis, and cuproptosis. Furthermore, copper ions can trigger macroautophagy/autophagy, a lysosome-dependent degradation pathway that plays a dual role in regulating the survival or death fate of cells under various stress conditions. Pathologic...
Source: Autophagy - April 14, 2023 Category: Cytology Authors: Qian Xue Rui Kang Daniel J Klionsky Daolin Tang Jinbao Liu Xin Chen Source Type: research
N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling
CONCLUSION: NAC treatment promoted the survival and differentiation of TSPCs to facilitate tendon repair after tendon injury in rats. Thus, NAC may be valuable for the treatment of tendon injury.PMID:36604630 | DOI:10.1186/s12860-022-00463-0
Source: Mol Biol Cell - January 5, 2023 Category: Molecular Biology Authors: Kang Lu Mei Zhou Liyuan Wang Yang Wang Hong Tang Gang He Huan Wang Chuyue Tang Jie He Wei Wang Kanglai Tang Yunjiao Wang Zhongliang Deng Source Type: research
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?
Neural Regen Res. 2022 May;17(5):933-936. doi: 10.4103/1673-5374.324827.ABSTRACTParkinson's disease is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons. Current treatment is focused on mitigating the symptoms through the administration of levodopa, rather than on preventing dopaminergic neuronal damage. Therefore, the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease. For...
Source: Cell Research - September 24, 2021 Category: Cytology Authors: Rita Caridade Silva Helena Sofia Domingues Ant ónio J Salgado F ábio G Teixeira Source Type: research
TNF promotes M1 polarization through mitochondrial metabolism in injured spinal cord
In this study, we found that ablation of TNF endorsed the beneficial conversion from M1 to M2 phenotype and improved the mitochondrial metabolism in vivo and in vitro. In addition, PGC-1α that accumulates in TNF null mice, a major participant of mitochondrial metabolism, downregulated ROS activity and the expressions of M1-specific mRNA. Moreover, the absence of TNF upgraded the morphology and quantity of damaged mitochondria and rapidly switched to M2 phenotype as compare to administration of N-Acetyl-l-cysteine (NAC). Furthermore, systemic application of TPEN showed that increased ratio of M1 M/Ms. These combined result...
Source: Free Radical Biology and Medicine - July 12, 2021 Category: Biology Authors: Sen Lin Zipeng Zhou Haosen Zhao Chang Xu Yue Guo Shuang Gao Xifan Mei He Tian Source Type: research
TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure
Aging (Albany NY). 2021 Jun 8;13. doi: 10.18632/aging.203080. Online ahead of print.ABSTRACTThe molecular mechanisms underlying premature ovarian failure, which seriously impacts the physical and psychological health of patients, are not fully understood. Here, we present the role of TRDMT1 in reactive oxygen species-induced granulosa cells death, which is considered an important cause of premature ovarian failure. We found that reactive oxygen species were increased in a H2O2 dose-dependent manner and accompanied by the nuclear shuttling of TRDMT1, increased DNA damage and increased apoptosis of granulosa cells. In additi...
Source: Aging - June 8, 2021 Category: Biomedical Science Authors: Chunli Sha Lu Chen Li Lin Taoqiong Li Hong Wei Meiling Yang Wujiang Gao Dan Zhao Qi Chen Yueqin Liu Xiaofang Chen Wenlin Xu Yuefeng Li Xiaolan Zhu Source Type: research
Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes
Toxicology. 2021 May 7:152811. doi: 10.1016/j.tox.2021.152811. Online ahead of print.ABSTRACTPreterm infants are at greater risk for adverse drug effects due to hepatic immaturity. Multiple interventions during intensive care increases potential for drug interactions. In this setting, high-dose caffeine used for apnea in premature infants may increase acetaminophen toxicity by inhibiting ataxia telangiectasia mutated (ATM) gene activity during DNA damage response. To define caffeine and acetaminophen interaction, we modeled infantile prematurity in late-gestation fetal stage through human immortalized hepatocytes and liver...
Source: Toxicology - May 10, 2021 Category: Toxicology Authors: Preeti Viswanathan Priya Gupta Yogeshwar Sharma Luka Maisuradze Sriram Bandi Sanjeev Gupta Source Type: research
Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair
Neoplasia. 2021 Apr 27;23(5):515-528. doi: 10.1016/j.neo.2021.04.003. Online ahead of print.ABSTRACTOvarian cancer (OC) is the deadliest gynecologic malignancy, which is mainly due to late-stage diagnosis and chemotherapy resistance. Therefore, new and more effective treatments are urgently needed. The in vitro effects of Panobinostat (LBH), a histone deacetylase inhibitor that exerts pleiotropic antitumor effects but induces autophagy, in combination with Chloroquine (CQ), an autophagy inhibitor that avoid this cell survival mechanism, were evaluated in 4 OC cell lines. LBH and CQ inhibited ovarian cancer cell proliferati...
Source: Neoplasia - April 30, 2021 Category: Cancer & Oncology Authors: Mar ía Ovejero-Sánchez Rogelio Gonz ález-Sarmiento Ana Bel én Herrero Source Type: research
