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Drug: Acetic Acid

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Total 4747 results found since Jan 2013.

Discovering, Characterizing, and Applying Acyl Homoserine Lactone-Quenching Enzymes to Mitigate Microbe-Associated Problems Under Saline Conditions
Conclusion In this study, bacterial species that proliferate under saline conditions were isolated and screened to select the ones that are positive for QQ under high salinity and high temperatures. Further genomic and biochemical characterization revealed a particularly promising AiiA from the Altererythrobacter sp. S1-5 that demonstrated a broad AHL substrate specificity range and enzymatic activity at an optimal pH of 8 and 50°C. AiiAS1-5 was also able to maintain good relative QQ activity with increasing salt concentrations up to 2 M. Its QQ efficacy against P. aeruginosa, A. hydrophila, and V. alginolyticus wa...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Topical antiseptics for chronic suppurative otitis media.
CONCLUSIONS: Due to paucity of the evidence and the very low certainty of that which is available the effectiveness and safety profile of antiseptics in the treatment of CSOM is uncertain. PMID: 31902140 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - January 5, 2020 Category: General Medicine Authors: Head K, Chong LY, Bhutta MF, Morris PS, Vijayasekaran S, Burton MJ, Schilder AG, Brennan-Jones CG Tags: Cochrane Database Syst Rev Source Type: research

Antibiotics versus topical antiseptics for chronic suppurative otitis media.
CONCLUSIONS: Treatment of CSOM with topical antibiotics (quinolones) probably results in an increase in resolution of ear discharge compared with boric acid at up to two weeks. There was limited evidence for the efficacy of other topical antibiotics or topical antiseptics and so we are unable to draw conclusions. Adverse events were not well reported. PMID: 31902139 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - January 5, 2020 Category: General Medicine Authors: Head K, Chong LY, Bhutta MF, Morris PS, Vijayasekaran S, Burton MJ, Schilder AG, Brennan-Jones CG Tags: Cochrane Database Syst Rev Source Type: research

Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus.
CONCLUSION: The agonists of FFAR1/GRP40 showed considerable potential for the therapeutic control of T2DM. Most of the small molecule FFAR1/GPR40 agonists developed were aryl alkanoic acid derivatives (such as phenylpropionic acids, phenylacetic acids, phenoxyacetic acids and benzofuran acetic acid derivatives) and thiazolidinediones. Some natural/plant derived compounds including fatty acids, sesquiterpenes, phenolic compounds, anthocyanins, isoquinoline and indole alkaloids were also reported as potent FFAR1 agonists. The clinical investigations of the FFAR1 agonists had demonstrated their probable role in the improvemen...
Source: Mini Reviews in Medicinal Chemistry - October 23, 2020 Category: Chemistry Authors: Rani L, Grewal AS, Sharma N, Singh S Tags: Mini Rev Med Chem Source Type: research

Evaluation on curative effects of ethylene diamine tetra-acetic acid chelation therapy in treating with atherosclerotic cardiovascular disease: A protocol for systematic review and meta-analysis
Conclusion: The study will infer the currently published evidence to evaluate curative effects of EDTA chelation therapy in patients with atherosclerotic cardiovascular disease, which might be beneficial to these patients. Ethics and dissemination: The present study is a systematic review, hence the pooled results are founded upon the published evidence. Therefore, ethical approval is not necessary for the study. Open Science Framework Registration Number: October 20, 2020.osf.io/tvmk8. (https://osf.io/tvmk8/).
Source: Medicine - December 24, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity
ConclusionThe potential direct bioactivity of GMB-derived indolic and phenolic molecules on primate CNS remains largely unknown. The field requires additional strategies to identify and prioritize screening of the most promising small molecules that enter the CNS.
Source: Metabolomics - January 6, 2022 Category: Biology Source Type: research

Alkyl esters of umbelliferone-4-acetic acid as protonophores in bilayer lipid membranes and ALDH2-dependent soft uncouplers in rat liver mitochondria
Bioelectrochemistry. 2022 Feb 2;145:108081. doi: 10.1016/j.bioelechem.2022.108081. Online ahead of print.ABSTRACTA great variety of coumarin-related compounds, both natural and synthetic, being often brightly fluorescent, have shown themselves beneficial in medicine for both therapeutic and imaging purposes. Here, in search for effective uncouplers of oxidative phosphorylation, we synthesized a series of 7-hydroxycoumarin (umbelliferone, UB) derivatives combining rather high membrane affinity with the presence of a hydroxyl group deprotonable at physiological pH - alkyl esters of umbelliferone-4-acetic acid (UB-4 esters) d...
Source: Bioelectrochemistry - February 8, 2022 Category: Biochemistry Authors: Vladimir S Krasnov Roman S Kirsanov Ljudmila S Khailova Alexander M Firsov Pavel A Nazarov Vadim N Tashlitsky Galina A Korshunova Elena A Kotova Yuri N Antonenko Source Type: research

Plant growth-promoting characteristics of halotolerant endophytic bacteria isolated from Sporobolus specatus (Vahr) Kunth and Cyperus laevigatus L. of Ethiopian rift valley lakes
The objective of this study was to isolate and characterize endophytic halotolerant bacterial isolates from haloalkaliphytes, investigate their plant growth-promoting (PGP) properties and tolerance for various stress conditions. Sporobolus specatus (Vahr) Kunth and Cyperus laevigatus L. grass samples were collected from the shores of two Ethiopian soda lakes (Lakes Abijata, and Chitu, respectively). A total of 167 halotolerant endophytic bacterial isolates, that clustered into 21 ARDRA (Amplified ribosomal DNA restriction analysis) groups, affiliated to members of 11 bacterial genera, namely Halomonas, Agrobacterium, Exigu...
Source: Archives of Microbiology - June 20, 2022 Category: Microbiology Authors: Solomon Enquahone Guido van Marle Addis Simachew Source Type: research

Cervical cancer prevention in countries with the highest HIV prevalence: a review of policies
CONCLUSION: Considerable progress has been made in policy development for CC prevention and control in sub Saharan Africa. However, in countries with a high HIV burden, there is need to tailor these policies to respond to the specific needs of WLHIV. Countries may consider updating policies using the recent WHO guidelines for CC prevention, while adapting them to context realities.PMID:35948944 | DOI:10.1186/s12889-022-13827-0
Source: Cancer Control - August 10, 2022 Category: Cancer & Oncology Authors: Serra Lem Asangbeh-Kerman Ma ša Davidović Katayoun Taghavi James Kachingwe Kereng Molly Rammipi Laura Muzingwani Magaret Pascoe Marielle Jousse Masangu Mulongo Mulindi Mwanahamuntu Neo Tapela Oluwasanmi Akintade Partha Basu Xolisile Dlamini Julia Bohliu Source Type: research

Brazilian red propolis accelerates gastric healing and reduces gastric submucosal layer inflammation in ultrasound-monitored rats
This study aimed to assess the gastric healing effect of the hydroalcoholic extract of red propolis (HERP) in the acetic acid-induced ulcer model. Rats under acetic acid-induced-ulcer were treated with HERP (100 mg/kg, p.o.) twice a day for seven days. Histological changes, oxidative stress, and inflammatory parameters were analyzed in the gastric tissue. Moreover, the gastric wall thickness was measured by ultrasound. The in vitro cytotoxicity of HERP and cellular migration of fibroblasts were evaluated. The treatment with HERP promoted gastric healing, reducing gastric wall thickness, macroscopic lesion area, and histopa...
Source: Chemistry and Biodiversity - November 29, 2022 Category: Biochemistry Authors: Thaise Boeing Beatriz Monteiro Magalh ães de Oliveira Jennyfer Andrea Aldana-Mej ía Gari Vidal Ccana-Ccapatinta Larissa Venzon Benhur Judah Cury Tauani Caroline Santos Fran ça Priscila de Souza Walter Ant ônio Roman Junior Lu ísa Mota da Silva Jairo Source Type: research