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Total 21 results found since Jan 2013.

Contemporary prevalence of carotid stenosis in patients presenting with ischaemic stroke.
CONCLUSION: Carotid stenosis is common, affecting one in five patients presenting with stroke or TIA. Careful MDT discussion may avoid unnecessary intervention and should be the standard of care. PMID: 30938840 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - April 1, 2019 Category: Surgery Authors: Cheng SF, Brown MM, Simister RJ, Richards T Tags: Br J Surg Source Type: research

Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke
CONCLUSION: RV offers an alternative predictive biomarker to traditional risk-scores for vascular health, without the need for blood sampling or blood pressure measurement. Further work is needed to examine RV in population screening to triage individuals at high-risk.PMID:36195457 | DOI:10.1136/bjo-2022-321842
Source: The British Journal of Ophthalmology - October 4, 2022 Category: Opthalmology Authors: Alicja Regina Rudnicka Roshan Welikala Sarah Barman Paul J Foster Robert Luben Shabina Hayat Kay-Tee Khaw Peter Whincup David Strachan Christopher G Owen Source Type: research

Age Is a Greater Influence on Small Saccades Than Target Size in Normal Subjects on the Horizontal Video Head Impulse Test
Conclusion: While this study suggests that target size may have a statistically significant impact on the vHIT saccade profile of normal subjects, age has a greater influence on the incidence and size of small vHIT saccades. Introduction The video head impulse test (vHIT) is a quantitative adaptation of the clinical head impulse test (1), and enables functional assessment of the high-frequency angular vestibulo-ocular reflex (VOR) in all three planes of head rotation (2, 3). Lightweight goggles worn by the subject detect head movement using an accelerometer and gyroscope, and a high frame rate video camera tracks eye...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Safety of 5914 intravitreal ziv-aflibercept injections.
CONCLUSION: This constitutes the largest pooled safety report on IVZ use and includes patients from 14 centres distributed across the globe. It shows that IVZ has an acceptable ocular and systemic safety profile with incidences of adverse events similar to those of other vascular endothelial growth factor inhibitory drugs. The analysis supports the continued use of IVZ in various retinal disorders. PMID: 30099379 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - August 11, 2018 Category: Opthalmology Authors: Singh SR, Stewart MW, Chattannavar G, Ashraf M, Souka A, ElDardeery M, Wadhwa N, Sarvaiya C, Mansour AM, Marashi A, Ramchandani S, Braimah IZ, Jabbarpoor Bonyadi MH, Ramezani A, Soheilian M, de Oliveira Dias JR, de Andrade GC, Maia A, Rodrigues EB, Farah Tags: Br J Ophthalmol Source Type: research

Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs
Conclusion The use of optical non-invasive diagnostic methods has a great potential for the detection of concomitant microcirculation disorders in patients with rheumatic diseases and diabetes. In this review, it was shown that the use of laser Doppler flowmetry, optical tissue oximetry and fluorescence spectroscopy together or separately may have important diagnostic value for the detection of violations, assessment of their severity, as well as for the analysis of the effectiveness of the therapy. The joint application of the considered technologies with the methods of machine learning (discriminant analysis) can be use...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Association of plasma retinol levels with incident cancer risk in Chinese hypertensive adults: a nested case-control study.
In conclusion, there was a significant inverse dose-response association between plasma retinol and the risk of digestive system cancers. However, a U-shaped association was observed between plasma retinol and the risk of non-digestive cancers (with a turning point approximately 68·2 μg/dl). PMID: 31352906 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - July 28, 2019 Category: Nutrition Authors: Xie L, Song Y, Lin T, Guo H, Wang B, Tang G, Liu C, Huang W, Yang Y, Ling W, Zhang Y, Li J, Huo Y, Wang X, Zhang H, Qin X, Xu X Tags: Br J Nutr Source Type: research

Ocular and systemic determinants of perifoveal and macular vessel parameters in healthy African Americans
CONCLUSIONS: When interpreting OCTA images in a clinical setting, it is important to consider the effects ocular and systemic characteristics may have on the macular microcirculation.PMID:34740885 | DOI:10.1136/bjophthalmol-2021-319675
Source: The British Journal of Ophthalmology - November 6, 2021 Category: Opthalmology Authors: Grace M Richter Jae Chang Lee Nasir Khan Alexander Vorperian Brennan Hand Bruce Burkemper Xiao Zhou Zhongdi Chu Ruikang Wang Rohit Varma Amir H Kashani Source Type: research

Nationwide trends in emergency department utilisation for acute retinal ischaemia in the USA, 2011-2018
CONCLUSION: Of the estimated 48 000 patients with TMVL or RAO annually in the USA, few are evaluated in the ED, and admission rates are less than for transient ischaemic attack or ischaemic stroke and are decreasing over time.PMID:35760457 | DOI:10.1136/bjo-2022-321418
Source: The British Journal of Ophthalmology - June 27, 2022 Category: Opthalmology Authors: Ali G Hamedani Lindsey B De Lott Allison W Willis Source Type: research

Risks of posterior segment ocular ischaemic events in patients with systemic lupus erythematosus: a population-based cohort study in Taiwan
CONCLUSIONS: SLE increases the risk of developing OIE. Systemic comorbidities and higher dosage of steroid in patients with SLE are associated with severe ocular ischaemic complications.PMID:35922126 | DOI:10.1136/bjo-2022-321653
Source: The British Journal of Ophthalmology - August 3, 2022 Category: Opthalmology Authors: Yi-Ran Chiou Yu-Sheng Chang Chin-Fang Su Tzu-Hao Li Chien-Chih Lai De-Kuang Hwang Fang-Yi Wu Yu-Fan Chang Source Type: research