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Total 638 results found since Jan 2013.

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Performance of the UKPDS Outcomes Model  2 for Predicting Death and Cardiovascular Events in Patients with Type 2 Diabetes Mellitus from a German Population-Based Cohort
ConclusionsThe study results demonstrate acceptable calibration and poor discrimination of the UKPDS-OM2 for predicting death and CV events in this population-based German sample. Those limitations should be considered when using the UKPDS-OM2 for economic evaluations of healthcare strategies or using the risk equations for clinical decision-making.
Source: PharmacoEconomics - July 26, 2019 Category: Health Management Source Type: research

Special report of the RSNA COVID-19 task force: systematic review of outcomes associated with COVID-19 neuroimaging findings in hospitalized patients
CONCLUSION: Among hospitalized COVID-19 patients with abnormal neuroimaging findings, those with ICH had the highest all-cause mortality; however, high mortality rates were also seen among COVID-19 patients with ischemic stroke in the acute/subacute period and leukoencephalopathy in the chronic period.ADVANCES IN KNOWLEDGE: Specific abnormal neuroimaging findings may portend differential mortality outcomes, providing a potential prognostic marker for hospitalized COVID-19 patients.PMID:33914618 | DOI:10.1259/bjr.20210149
Source: The British Journal of Radiology - April 29, 2021 Category: Radiology Authors: Monique A Mogensen Pattana Wangaryattawanich Jason Hartman Christopher G Filippi Daniel S Hippe Nathan M Cross Source Type: research

Sleep and physical activity in relation to all-cause, cardiovascular disease and cancer mortality risk
CONCLUSION: The detrimental associations of poor sleep with all-cause and cause-specific mortality risks are exacerbated by low PA, suggesting likely synergistic effects. Our study supports the need to target both behaviours in research and clinical practice.PMID:34187783 | DOI:10.1136/bjsports-2021-104046
Source: British Journal of Sports Medicine - June 30, 2021 Category: Sports Medicine Authors: Bo-Huei Huang Mitch J Duncan Peter A Cistulli Natasha Nassar Mark Hamer Emmanuel Stamatakis Source Type: research

P-030 Mechanical thrombectomy in medium vessel occlusions using the novel aspiration MIVI Q catheters: an international multicenter experience
ConclusionsTreatment of MeVO patients with Q catheters resulted in optimal angiographic and clinical outcomes. Though angiographic results were similar between primary and secondary MeVOs, the first had less severe presentation and better outcomes at 90-days than the latter.Disclosures A. Monteiro: None. L. Makalanda: None. J. Wareham: None. J. Jones: None. P. Dhillon: None. P. Bhogal: None. W. Brinjikji: None. M. Mokin: None. A. Siddiqui: 1; C; Co-investigator for NIH – 1R01EB030092–01, Project Title: High Speed Angiography at 1000 frames per second; Mentor for Brain Aneurysm Foundation Carol W. Harvey Chair o...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Monteiro, A., Makalanda, L., Wareham, J., Jones, J., Dhillon, P., Bhogal, P., Brinjikji, W., Mokin, M., Siddiqui, A. Tags: SNIS 19th annual meeting oral poster abstracts Source Type: research

High-resolution vessel wall magnetic resonance imaging in intracranial vasculopathies: an experience from eastern India
CONCLUSION: Adjunctive use of HR-IVWI, to clinical and luminal assessment, can significantly improve diagnostic accuracy during evaluation of intracranial vasculopathies, with its greatest utility in diagnosing in ICAD, CNS angiitis and dissection.ADVANCES IN KNOWLEDGE: HR-IVWI allows clearer etiological distinction of intracranial vasculopathies having therapeutic and prognostic implications.PMID:37066831 | DOI:10.1259/bjr.20230114
Source: The British Journal of Radiology - April 17, 2023 Category: Radiology Authors: Shambaditya Das Mahmud Mossa-Basha Mousam Dey Avijit Hazra Alak Pandit Gautam Das Souvik Dubey Biman Kanti Ray Source Type: research

Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study
ConclusionMultifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI.
Source: BJU International - March 7, 2018 Category: Urology & Nephrology Authors: Alex Tsui, Diana Kuh, Linda Cardozo, Daniel Davis Tags: Original Article Source Type: research

Reperfusion in the brain: is time important? The DAWN and DEFUSE-3 trials
Professor Tom Robinson is Head of the Department of Cardiovascular Sciences at the University of Leicester, National Specialty Lead for the National Institute for Health Research Clinical Research Network, and President of the British Association of Stroke Physicians. Professor Robinson works as a Stroke Physician, and his research focus is on clinical trials in acute stroke, particularly blood pressure and thrombolysis management, and studies of cardiovascular and cerebrovascular regulatory mechanisms.
Source: Cardiovascular Research - March 24, 2018 Category: Cardiology Source Type: research

Cardiac Structure and Function in Morbidly Obese Parturients: An Echocardiographic Study.
CONCLUSIONS: Cardiac index did not differ between obese pregnant women and those with normal BMI. Their increased left ventricular mass and lower stroke volume index could indicate a limited adaptive reserve. Obese women had minor decreases in septal left ventricular tissue Doppler velocity, but the E/E' average values did not suggest clinically significant diastolic dysfunction. PMID: 29878938 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - June 5, 2018 Category: Anesthesiology Authors: Buddeberg BS, Fernandes NL, Vorster A, Cupido BJ, Lombard CJ, Swanevelder JL, Girard T, Dyer RA Tags: Anesth Analg Source Type: research

Clinical Impact of 5  Years of Liraglutide Treatment on Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus in a Real-Life Setting in Italy: An Observational Study
ConclusionIn patients prolonging treatment with liraglutide for 5  years, the benefits in relation to metabolic control and CV risk factors are maintained. The UKPDS risk scores suggest that liraglutide is associated with a reduced CHD risk, but not with a reduced stroke risk.
Source: Diabetes Therapy - September 20, 2018 Category: Endocrinology Source Type: research