Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study
ConclusionMultifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI.
In conclusion, our results indicate that LRP1 promotes the dedifferentiation of PASMC from a contractile to a synthetic phenotype thus suggesting its contribution to vascular remodeling in PH.
ConclusionOur study suggests a VDR-mediated metabolic cross-talk between gut and adipose tissue, which significantly contributes to systemic lipid homeostasis. These results have important implications for use of the intestinal VDR as a therapeutic target for obesity and associated disorders.
Publication date: Available online 21 March 2019Source: Redox BiologyAuthor(s): Tsung-Ming Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong LinAbstractLeft ventricular hypertrophy (LVH) in hypertension has prognostic significance on cardiovascular mortality and morbidity. Recently, we have shown that n-butylidenephthalide (BP) improves human adipose-derived stem cell (hADSC) engraftment via attenuated reactive oxygen species (ROS) production. This prompted us to investigate whether remote transplantation of BP-pretreated hADSCs confers attenuated LVH at an est...
Publication date: Available online 21 March 2019Source: MitochondrionAuthor(s): Hamza El Hadi, Roberto Vettor, Marco RossatoAbstractCardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward...
ConclusionsO-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.General significanceThis study first indicates that STRA6-retinol signals were directly disrupted by O-GlcNAcylation in diabetic kidney.
Publication date: June 2019Source: Microchemical Journal, Volume 147Author(s): Hanan I. EL-Shorbagy, Fawzi Elsebaei, Sherin F. Hammad, Amina M. El-BrashyAbstractA simple, rapid, selective, linear, precise, accurate and eco-friendly RP-HPLC-UV-Fluorescence method was developed by 23 full factorial design and validated for simultaneous assay of sofosbuvir and ledipasvir mixture in tablet dosage form within 7 min without interference of tablet excipients. Isocratic elution at a flow rate of 1.2 mL min−1 was employed on C18 (250 mm × 4.6 mm, 5 μm in particle size) at ambient temperature. Th...
Faraday Discuss., 2019, Accepted Manuscript DOI: 10.1039/C8FD00223A, PaperYong Zhao, Kenneth T. Kongstad, Yueqiu Liu, he chenghua, Dan Staerk Medicinal plants have been widely used as (poly)pharmacological remedies and constitute a rich source for anti-diabetic drug discovery. In the present study, forty medicinal plant samples collected in China were... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC01534E, CommunicationNeha Thakur, Mukesh Kumar, Subhasis D. Adhikary, Debaprasad Mandal, Tharamani Chikka Nagaiah To address the issues allied with cardiovascular diseases and increased prevalence of hypertension, a novel electrochemical sensor was developed based on poly(ionic liquid) [PVIM] –cobalt polyoxometalate (Co5POM) supported on carbonaceous materials... The content of this RSS Feed (c) The Royal Society of Chemistry
Sweat works like blood for health monitoring University of Cincinnati, Abbott Diabetes Care, Salimetrics LLC, Eccrine Systems, Inc. Climate change impact when temperature determines ...This is an NSF Multimedia Gallery item.
Conclusion: Therefore, considering the role of myonectin in increasing fatty acid uptake, exercise training can play an essential role in decreasing obesity-related diseases and metabolic syndrome; this effect is partly related to the roles of myonectin. Therefore, the use of this type of exercise is recommended to reduce the risk of diseases associated with obesity and metabolic syndrome. PMID: 30894898 [PubMed - in process]