Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study

ConclusionMultifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI.
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research

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Publication date: Available online 21 July 2018Source: Journal of Molecular BiologyAuthor(s): Michela Miani, Bernat Elvira, Esteban N. GurzovAbstractDiabetes is a metabolic disorder affecting more than 400 million individuals and their families worldwide. The major forms of diabetes (type 1 and 2) are characterized by pancreatic β-cell dysfunction and, in some cases, loss of β-cell mass causing hyperglycemia due to absolute or relative insulin deficiency. The BCL-2 homology 3 (BH3)-only protein BIM has a wide role in apoptosis induction in cells. In this review, we describe the apoptotic mechanisms mediated by BI...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 21 July 2018Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): X. Liu, D. Zhang, Y. Liu, X. Sun, Y. Hou, B. Wang, Y. Ren, Y. Zhao, C. Han, C. Cheng, F. Liu, Y. Shi, X. Chen, L. Liu, G. Chen, S. Hong, M. Zhang, D. HuAbstractBackground and aimMany studies have shown increased risk of stroke with greater adiposity as measured by body mass index (BMI), but questions remain about the shape of the dose–response relation. We conducted a systematic review and meta-analysis of prospective studies to clarify the strength and shape of the dose–response relation between B...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
(MedPage Today) -- This week's topics include tick-borne illness, late life blood pressure and stroke, a simple ED intervention to reduce suicidality, and fecal occult blood and mortality.
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In conclusion, gallic acid and p-coumaric acid exhibited marked antidiabetic action that could be mediated via modulation of TNF-α and adipocytokines secretions as well as upregulation of PPARγ mRNA expression. PMID: 30021345 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
ute;dez-Ocaña DY Abstract Erythropoietin (EPO) is required for promoting the progress of erythroid differentiation. However, the discovery of EPO and the EPO receptor (EPOR) in the nervous system may contribute to new treatment strategies for the use of EPO in neurodegenerative disorders. Diabetic neuropathy is a neurodegenerative disease that affects a large proportion of diabetic patients and results in alterations in functionality, mood and sleep. The pathogenic mechanisms generating diabetic neuropathy involve: Schwannopathy, polyol pathway activity, advanced glycation end-products (AGEs) accumulation, ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
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Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
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Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Abstract Chios mastic gum (CMG) exerts robust anti-inflammatory and antioxidant properties and it affects pathways that are implicated in the pathophysiology of endothelial and vascular inflammation. Aim of this study was to test the hypothesis that CMG administration lowers blood pressure (BP) and improves hypertension-induced target organ damage. 2-kidney, 1-clip (2K1C) hypertensive rats were treated with CMG (40 mg/kg body weight/day) for 2-weeks after the establishment of hypertension. Acute CMG administration lowered systolic, diastolic and mean arterial BP, while these hemodynamic effects were sustained th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
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