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Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis
Conclusion: We found a statistically insignificant tendency for the ultrasound-measured length of sICAS<70% to be longer than that of sICAS≥70%. Moreover, the ultrasound-measured length of sICAS<90% was significantly longer than that of sICAS 90%. Among patients with sICAS≥70%, the degree and length of stenosis were inversely correlated. Larger studies are needed before a clinical implication can be drawn from these results. Introduction Internal carotid artery stenosis (ICAS) causes around one-fifth of ischemic cerebrovascular stroke and has the highest risk of early stroke recurrence...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Poor glycemic control and posterior circulation ischemic stroke
Conclusions Poor glycemic control may be associated with an increased risk of thrombotic infarction that occurs preferentially in the posterior circulation of the brain.
Source: Neurology Clinical Practice - April 7, 2019 Category: Neurology Authors: Kuroda, J., Matsuo, R., Yamaguchi, Y., Sato, N., Kamouchi, M., Hata, J., Wakisaka, Y., Ago, T., Kitazono, T., on behalf of the Fukuoka Stroke Registry Investigators Tags: Infarction Research Source Type: research

Relationships between Alcohol Intake and Ischemic Stroke Severity in Sex Stratified Analysis for Japanese Acute Stroke Patients
The aim of this study is to evaluate in the relationships between alcohol intake and ischemic stroke severity in Japanese stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - March 20, 2019 Category: Neurology Authors: Hiroyuki Shiotsuki, Yasuaki Saijo, Yoichi Ogushi, Shotai Kobayashi, The Japan Standard Stroke Registry Study Group Source Type: research

Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I)
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Akira Ogawa, Kazunori Toyoda, Kazuo Kitagawa, Takanari Kitazono, Takehiko Nagao, Hiroshi Yamagami, Shinichiro Uchiyama, Norio Tanahashi, Masayasu Matsumoto, Kazuo Minematsu, Izumi Nagata, Masakatsu Nishikawa, Shinsuke Nanto, Kenji Abe, Yasuo Ikeda, PRASTRO-I Study GroupSummaryBackgroundThe effect of prasugrel in terms of the prevention of recurrence of ischaemic stroke is unknown. We investigated the non-inferiority of prasugrel to clopidogrel for prevention of ischaemic stroke, myocardial infarction, and death from other vascular causes...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Sub-classification of apraxia of speech in patients with cerebrovascular and neurodegenerative diseases.
Abstract Some studies have hypothesized that primary progressive apraxia of speech (ppAOS) consists of heterogeneous symptoms that can be sub-classified; however, no study has classified stroke-induced AOS (sAOS) and ppAOS according to common criteria. The purpose of this study was to elucidate the symptoms and relevant brain regions associated with sAOS and ppAOS for sub-classification. Participants included 8 patients with sAOS following lesions in the left precentral gyrus and/or underlying white matter, and 3 patients with ppAOS. All patients with sAOS could be classified into three subtypes: type I, with prom...
Source: Brain and Cognition - January 7, 2019 Category: Neurology Authors: Takakura Y, Otsuki M, Sakai S, Tajima Y, Mito Y, Ogata A, Koshimizu S, Yoshino M, Uemori G, Takakura S, Nakagawa Y Tags: Brain Cogn Source Type: research

Thrombectomy for Stroke at 6-24 hours without Perfusion CT Software for Patient Selection
This study aimed to elucidate the efficacy of thrombectomy 6-24 hours after onset in our patient cohort using conventional imaging mismatch.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2018 Category: Neurology Authors: Junya Tsurukiri, Takahiro Ota, Hiroyuki Jimbo, Eitaro Okumura, Keigo Shigeta, Tatsuo Amano, Masayuki Ueda, Yuji Matsumaru, Yoshiaki Shiokawa, Teruyuki Hirano Source Type: research

Risk Factors for Hemorrhagic and Cardioembolic Complications of Intracerebral Hemorrhage Associated with Anticoagulants
This study investigated hemorrhagic and cardioembolic events and risk factors in intracerebral hemorrhage patients taking anticoagulants. Methods: The clinical data of 65 consecutive intracerebral hemorrhage patients taking anticoagulants were retrospectively reviewed.
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2018 Category: Neurology Authors: Sho Osawa, Tatsuya Shimizu, Tadashige Kano, Ryosuke Shintoku, Hiroya Fujimaki, Ken Asakura Source Type: research

Association of survival and hyperthermia after rt ‐PA for ischemic stroke
ConclusionsHyperthermia within 3  days after rt‐PA is associated with poor functional prognosis and survival outcome in patients with acute cerebral infarction.
Source: Acta Neurologica Scandinavica - November 4, 2018 Category: Neurology Authors: Tatsuya Ueno, Haruo Nishijima, Hiroki Hikichi, Rie Haga, Akira Arai, Chieko Suzuki, Jin ‐ichi Nunomura, Masahiko Tomiyama Tags: CLINICAL COMMENTARY Source Type: research

Trends of Antiplatelet Therapy for the Management of Moyamoya Disease in Japan: Results of a Nationwide Survey
This study reports results of a nationwide survey conducted in 2016 on the trends of antiplatelet therapy for moyamoya disease in Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - September 14, 2018 Category: Neurology Authors: Koichi Oki, Masahiro Katsumata, Yoshikane Izawa, Shinichi Takahashi, Norihiro Suzuki, Kiyohiro Houkin, Research Committee on Spontaneous Occlusion of Circle of Willis (Moyamoya disease) Source Type: research

Moderate-to-vigorous physical activity and the risk of stroke recurrence in patients with a history of minor ischemic stroke in Japan: a retrospective analysis.
CONCLUSIONS: Patients with a history of mild ischemic stroke had low MVPA and high VFL values, which together may be a risk factor for RIS. PMID: 30207894 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 12, 2018 Category: Neurology Authors: Ushio M, Kanaoka M, Kinoshita Y, Maeno S, Fujita K Tags: Top Stroke Rehabil Source Type: research

Screening for Fabry Disease in Japanese Patients with Young-Onset Stroke by Measuring α-Galactosidase A and Globotriaosylsphingosine
Fabry disease is an X-linked lysosomal storage disorder caused by mutations in GLA, which encodes the enzyme α-galactosidase A (α-Gal A). Although the prevalence of Fabry disease in patients with stroke has been reported to range from 0% to 4%, few cohort studies have examined Japanese stroke patients. We aimed to clarify the prevalence of Fabry disease and the frequency of GLA mutations among patients w ith young-onset stroke in Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2018 Category: Neurology Authors: Naoto Kinoshita, Naohisa Hosomi, Hayato Matsushima, Masahiro Nakamori, Yoshiki Yagita, Takemori Yamawaki, Tsuyoshi Torii, Takeshi Kitamura, Yoshimasa Sueda, Ryo Shimomura, Mutsuko Araki, Tomohisa Nezu, Shiro Aoki, Satoshi Ishii, Hiroki Maruyama, Masayasu Source Type: research

Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene
In conclusion, EC-SOD overexpression by HVJ-E vector inhibits neointima hyperpl asia, inflammation, and ROS level triggered by balloon injury. The modulation of cell growth-signaling pathways by EC-SOD in VSMCs might play an important role in these inhibitory effects.
Source: Translational Stroke Research - September 6, 2018 Category: Neurology Source Type: research

Regionwide Retrospective Survey of Acute Mechanical Thrombectomy in Tama, Suburban Tokyo: A Preliminary Report
This study examined the challenges facing mechanical thrombectomy in the Tama area (population, 4.3 million), a densely populated urban area of Tokyo, Japan, and analyzed retrospective data from the Tama-REgistry of Acute endovascular Thrombectomy.
Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2018 Category: Neurology Authors: Takahiro Ota, Keigo Shigeta, Tatsuo Amano, Masayuki Ueda, Teruyuki Hirano, Yuji Matsumaru, Yoshiaki Shiokawa Tags:   Source Type: research

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