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Dl-3-n-butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal-enriched protein tyrosine phosphatase/ERK/cAMP-response element-binding protein signaling pathway
In conclusion, the present study provided evidence to suggest that the new drug NBP improved amyloid-induced learning and memory deficits, likely through the regulation of the STEP/ERK/CREB pathway. The results revealed that NBP, as a multi-target drug, may exert a neuroprotective effect. Therefore, NBP may serve as an effective treatment for AD.PMID:35350668 | PMC:PMC8943801 | DOI:10.3892/etm.2022.11248
Source: Experimental and Therapeutic Medicine - March 30, 2022 Category: General Medicine Authors: Yan Zhao Wen-Qiang Yang Lu Yu Jing Yang Hai-Rong Zhu Lin Zhang Source Type: research

Obstructive sleep apnea is associated with cognitive impairment in minor ischemic stroke
CONCLUSIONS: The findings suggest that OSA has significant effects on cognition impairment in patients with minor ischemic stroke and that hypoxemia may be a potential pathophysiological mechanism of OSA-induced cognitive impairment.PMID:35305233 | DOI:10.1007/s11325-022-02575-5
Source: Sleep and Breathing - March 19, 2022 Category: Sleep Medicine Authors: Ruo-Lin Zhu Chao Ouyang Ruo-Lin Ma Kai Wang Source Type: research

Associations between short-term ambient ozone exposure and cause-specific mortality in rural and urban areas of Jiangsu, China
Environ Res. 2022 Mar 11:113098. doi: 10.1016/j.envres.2022.113098. Online ahead of print.ABSTRACTMost previous studies on the acute health effects of ozone are limited to urban areas, largely due to the paucity of air pollutant measurements in rural areas. We here estimated the county-specific daily maximum 8-h average ozone concentration in Jiangsu Province, China during 2015-2018, using a recently developed spatiotemporal machine learning model at a spatial resolution of 0.1° × 0.1° (∼11 × 11 km). Counties were equally divided into urban and rural groups based on the median of the percentage of urban residents acr...
Source: Environmental Research - March 15, 2022 Category: Environmental Health Authors: Chengyi Lin Yiqun Ma Riyang Liu Yanchuan Shao Zongwei Ma Lian Zhou Yuanshu Jing Michelle L Bell Kai Chen Source Type: research

Radiomics-based prediction of hemorrhage expansion among patients with thrombolysis/thrombectomy related-hemorrhagic transformation using machine learning
CONCLUSIONS: The currently established NECT-based radiomic score is valuable in predicting hemorrhage expansion after HT among patients treated with reperfusion treatment after ischemic stroke, which may aid clinicians in determining patients with HT who are most likely to benefit from anti-expansion treatment.PMID:35173809 | PMC:PMC8842178 | DOI:10.1177/17562864211060029
Source: Adv Data - February 17, 2022 Category: Epidemiology Authors: Junfeng Liu Wendan Tao Zhetao Wang Xinyue Chen Bo Wu Ming Liu Source Type: research

Prediction of Communication Impairment in Children With Bilateral Cerebral Palsy Using Multivariate Lesion- and Connectome-Based Approaches: Protocol for a Multicenter Prospective Cohort Study
DiscussionThe findings of the study may lead to the development of several translational tools that can individually predict communication impairment in children newly diagnosed with BCP to ensure that these children receive early, targeted therapeutic intervention before they begin school.Trial registrationThe study has been registered with the Chinese Clinical Trial Registry (ChiCTR2100049497).
Source: Frontiers in Human Neuroscience - January 31, 2022 Category: Neuroscience Source Type: research

Based on voxel-based morphological analysis to investigate the effect of acupuncture-rehabilitation therapy on hippocampal volume and its neuroprotective mechanism in patients with vascular cognitive impairment with type 2 diabetes mellitus: A study protocol
Discussion: This trial can clarify the effect of acupuncture-rehabilitation therapy on hippocampal volume and its intervention mechanism on oxidative stress injury in VCI patients with T2DM, and clarify the scientific connotation of its neuroprotective mechanism in the VCI patients with T2DM, in order to provide a theoretical basis for the clinical application of acupuncture-rehabilitation therapy in the treatment of VCI. Trial registration: Chinese Clinical Trial Registry (ChiCTR), ChiCTR2100047803. Registered 26 June, https://www.chictr.org.cn/showproj.aspx?proj=128707
Source: Medicine - December 23, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Prediction-Driven Decision Support for Patients With Mild Stroke: A Model Based on Machine Learning Algorithms
Conclusions: DAMS and R-DAMS, as prediction-driven decision support tools, were designed to aid clinical decision-making for mild stroke patients in emergency contexts. In addition, even within a narrow range of baseline scores, NIHSS on admission is the strongest feature that contributed to the prediction.
Source: Frontiers in Neurology - December 23, 2021 Category: Neurology Source Type: research

An Improved Deep Learning Model: S-TextBLCNN for Traditional Chinese Medicine Formula Classification
Conclusion: The combination of formula feature representation and the S-TextBLCNN model improve the accuracy in formula efficacy classification. It provides a new research idea for the study of TCM formula compatibility.
Source: Frontiers in Genetics - December 22, 2021 Category: Genetics & Stem Cells Source Type: research

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