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Total 391 results found since Jan 2013.

Canadian Stroke Best Practice Recommendations: Acute Stroke Management, 7 < sup > th < /sup > Edition Practice Guidelines Update, 2022
Can J Neurol Sci. 2022 Dec 19:1-94. doi: 10.1017/cjn.2022.344. Online ahead of print.NO ABSTRACTPMID:36529857 | DOI:10.1017/cjn.2022.344
Source: The Canadian Journal of Neurological Sciences - December 18, 2022 Category: Neurology Authors: Manraj Heran Patrice Lindsay Gord Gubitz Amy Yu Aravind Ganesh Rebecca Lund Sacha Arsenault Doug Bickford Donnita Derbyshire Shannon Doucette Esseddeeg Ghrooda Devin Harris Nick Kanya-Forstner Eric Kaplovitch Zachary Liederman Shauna Martiniuk Marie McCle Source Type: research

Direct to Angiosuite in Acute Stroke with Mobile Stroke Unit
Can J Neurol Sci. 2023 Mar 29:1-17. doi: 10.1017/cjn.2023.36. Online ahead of print.NO ABSTRACTPMID:36987939 | DOI:10.1017/cjn.2023.36
Source: The Canadian Journal of Neurological Sciences - March 29, 2023 Category: Neurology Authors: Radhika Nair Jeremy Rempel Khurshid Khan Thomas Jeerakathil Rene Van Dijk Brian H Buck Mahesh P Kate Sibi Thirunavukkarasu Kimberly Gilbertson Sathvika Thermalingem Ashfaq Shuaib Source Type: research

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study
Publication date: Available online 30 April 2018 Source:The Lancet Neurology Author(s): Cyril Pottier, Xiaolai Zhou, Ralph B Perkerson, Matt Baker, Gregory D Jenkins, Daniel J Serie, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Adolfo López de Munain, Miren Zulaica, Fermin Moreno, Isabelle Le Ber, Florence Pasquier, Didier Hannequin, Raquel Sánchez-Valle, Anna Antonell, Albert Lladó, Tammee M Parsons, NiCole A Finch, Elizabeth C Finger, Carol F Lippa, Edward D Huey, Manuela Neumann, Peter Heutink, Matthis Synofzik, Carlo Wilke, Robert A Rissman, Jaroslaw Slawek, Emilia Sitek, Peter Johannsen, Jørgen E Nielsen, Yi...
Source: The Lancet Neurology - May 1, 2018 Category: Neurology Source Type: research

Long-Term Outcomes in the Management of Central Neuropathic Pain Syndromes: A Prospective Observational Cohort Study.
CONCLUSION: Patients with central neuropathic pain syndromes managed in tertiary care centers were less likely to achieve a meaningful improvement in pain and function compared with patients with peripheral neuropathic pain at 12-month follow-up. PMID: 29996953 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - July 12, 2018 Category: Neurology Authors: Staudt MD, Clark AJ, Gordon AS, Lynch ME, Morley-Forster PK, Nathan H, Smyth C, Stitt LW, Toth C, Ware MA, Moulin DE Tags: Can J Neurol Sci Source Type: research

rTMS Effects in Patients with Co-Morbid Somatic Pain and Depressive Mood Disorders
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation treatment that involves the induction of electrical currents in a targeted region of the brain with the ability to impact various functional processes (Chervyakov  et al., 2015). rTMS has shown to provide clinical improvement among a variety of neurological and psychiatric disorders and has been FDA-approved for treatment resistant depression (TRD). rTMS continues to undergo trials for other treatment indications including post-traumatic stress disorder (PT SD), generalized anxiety disorder (GAD), bipolar depression, schizophrenia, stro...
Source: Journal of Affective Disorders - August 18, 2018 Category: Neurology Authors: Angela L. Phillips, Robert L. Burr, David L. Dunner Tags: Research paper Source Type: research

ƒPublication trends in transcranial magnetic stimulation: a 30-year panorama
ConclusionThis study implemented a systematic, bibliometric approach to quantitively assess the breadth of the TMS literature base and identify temporal publication and authorship trends. Drawing on these insights may aid understanding of historical progress in TMS over the last 30 years and help identify into unmet needs and opportunities to improve scientific and publishing practices to contribute to the future health of the field. These findings are likely to be relevant to researchers, clinicians, funders, industry collaborators and other stakeholders.
Source: Brain Stimulation - January 10, 2019 Category: Neurology Source Type: research

Publication trends in transcranial magnetic stimulation: a 30-year panorama
ConclusionThis study implemented a systematic, bibliometric approach to quantitively assess the breadth of the TMS literature base and identify temporal publication and authorship trends. Drawing on these insights may aid understanding of historical progress in TMS over the last 30 years and help identify into unmet needs and opportunities to improve scientific and publishing practices to contribute to the future health of the field. These findings are likely to be relevant to researchers, clinicians, funders, industry collaborators and other stakeholders.
Source: Brain Stimulation - January 18, 2019 Category: Neurology Source Type: research

The 2018 ter Brugge Lecture: Problems with the Introduction of Innovations in Neurovascular Care.
Abstract Most endovascular innovations have been introduced into clinical care by showing good outcomes in small enthusiastic case series of selected patients. Randomized clinical trials (RCTs) have rarely been performed, except for acute ischemic stroke, but even then most trial designs were too explanatory to inform clinical decisions. In this article, we review 2 × 2 tables and forest plots that summarize RCT results to examine methodological issues in the design and interpretation of clinical studies. Research results can apply in practice when RCTs are all-inclusive, pragmatic trials. Common problems inclu...
Source: The Canadian Journal of Neurological Sciences - February 21, 2019 Category: Neurology Authors: Raymond J, Fahed R, Roy D, Darsaut TE Tags: Can J Neurol Sci Source Type: research

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial
Publication date: Available online 18 March 2019Source: The Lancet NeurologyAuthor(s): Magdy Selim, Lydia D Foster, Claudia S Moy, Guohua Xi, Michael D Hill, Lewis B Morgenstern, Steven M Greenberg, Michael L James, Vineeta Singh, Wayne M Clark, Casey Norton, Yuko Y Palesch, Sharon D Yeatts, Monica Dolan, Erlinda Yeh, Kevin Sheth, Kimberly Kunze, Susanne Muehlschlegel, Iryna Nieto, Jan ClaassenSummaryBackgroundIron from haemolysed blood is implicated in secondary injury after intracerebral haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in patients with intracerebral haemorrhage and to...
Source: The Lancet Neurology - March 19, 2019 Category: Neurology Source Type: research

Characteristic Cerebrovascular Findings Associated with ACTA2 Gene Mutations.
Abstract A specific mutation (Arg179) of the ACTA2 gene has previously been described to cause a syndrome of multisystemic smooth muscle dysfunction with an extremely characteristic cerebrovascular appearance.1 Accurate neuroimaging diagnosis of this entity is important as this syndrome predisposes to complications such as early-onset ischemic stroke and ascending thoracic aortic aneurysm.2,3 The following case demonstrates a previously undescribed ACTA2 mutation (Met46) with an identical cerebrovascular imaging appearance to that of Arg179 mutations, but a less severe overall phenotype. PMID: 30975232 [PubMe...
Source: The Canadian Journal of Neurological Sciences - April 11, 2019 Category: Neurology Authors: Zhang A, Jo A, Grajewski K, Kim J Tags: Can J Neurol Sci Source Type: research

GFR-Specific versus GFR-Agnostic Cutoffs for Parathyroid Hormone and Fibroblast Growth Factor-23 in Advanced Chronic Kidney Disease
Conclusion: GFR-specific risk-based cutoffs for PTH1 –84 and FGF-23 may facilitate more meaningful risk stratification in advanced CKD than current GFR-agnostic reference ranges derived from healthy adults. This may be most applicable in those with severely reduced GFR.Am J Nephrol
Source: American Journal of Nephrology - June 25, 2019 Category: Neurology Source Type: research

Activity Performance, Participation, and Quality of Life Among Adults in the Chronic Stage After Acquired Brain Injury —The Feasibility of an Occupation-Based Telerehabilitation Intervention
Conclusions: This pilot study demonstrated the feasibility of a metacognitive occupation-based telerehabilitation intervention and its potential benefits in activity performance, participation, and QoL for older adults coping with long-term disability following ABI.Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03048708.
Source: Frontiers in Neurology - December 5, 2019 Category: Neurology Source Type: research

Association between aluminum in drinking water and incident Alzheimer's disease in the Canadian Study of Health and Aging cohort.
Abstract Epidemiological evidence linking aluminum in drinking water and Alzheimer's disease (AD) has been inconsistent, with previous studies often limited by small sample sizes. The present study addresses this issue using data from the Canadian Study of Health and Aging (CSHA), a prospective cohort of 10,263 subjects followed-up from 1991-1992 through 2001-2002. Participants' residential histories were linked to municipal drinking water sources in 35 Canadian municipalities to obtain ecologic pH, aluminum, fluoride, iron and silica concentrations in drinking water. Cox proportional hazards models were used to e...
Source: Neurotoxicology - April 28, 2020 Category: Neurology Authors: Van Dyke N, Yenugadhati N, Birkett NJ, Lindsay J, Turner MC, Willhite CC, Krewski D Tags: Neurotoxicology Source Type: research