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Determinants Influencing the Prestroke Health Behaviors and Cardiovascular Disease Risk of Stroke Patients: A Cross-Sectional Study
Background: Knowledge about stroke and stroke prevention may provide motivation to lead a healthy lifestyle to prevent stroke. The goal of this study is to quantify the knowledge of stroke and stroke prevention of patients with a recent stroke and its association with health behaviors and cardiovascular disease risk. Methods: We conducted a prospective cross-sectional study utilizing consecutive stroke admissions at 2 hospitals in Vancouver, Canada. We included patients within 48-72hours of admission.
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2019 Category: Neurology Authors: Beena P. Parappilly, Thalia S. Field, William B. Mortenson, Brodie M. Sakakibara, Janice J. Eng Source Type: research

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial
Publication date: Available online 18 March 2019Source: The Lancet NeurologyAuthor(s): Magdy Selim, Lydia D Foster, Claudia S Moy, Guohua Xi, Michael D Hill, Lewis B Morgenstern, Steven M Greenberg, Michael L James, Vineeta Singh, Wayne M Clark, Casey Norton, Yuko Y Palesch, Sharon D Yeatts, Monica Dolan, Erlinda Yeh, Kevin Sheth, Kimberly Kunze, Susanne Muehlschlegel, Iryna Nieto, Jan ClaassenSummaryBackgroundIron from haemolysed blood is implicated in secondary injury after intracerebral haemorrhage. We aimed to assess the safety of the iron chelator deferoxamine mesylate in patients with intracerebral haemorrhage and to...
Source: The Lancet Neurology - March 19, 2019 Category: Neurology Source Type: research

The 2018 ter Brugge Lecture: Problems with the Introduction of Innovations in Neurovascular Care.
Abstract Most endovascular innovations have been introduced into clinical care by showing good outcomes in small enthusiastic case series of selected patients. Randomized clinical trials (RCTs) have rarely been performed, except for acute ischemic stroke, but even then most trial designs were too explanatory to inform clinical decisions. In this article, we review 2 × 2 tables and forest plots that summarize RCT results to examine methodological issues in the design and interpretation of clinical studies. Research results can apply in practice when RCTs are all-inclusive, pragmatic trials. Common problems inclu...
Source: The Canadian Journal of Neurological Sciences - February 21, 2019 Category: Neurology Authors: Raymond J, Fahed R, Roy D, Darsaut TE Tags: Can J Neurol Sci Source Type: research

Cognitive strategy on upper extremity function for stroke: A randomized controlled trials.
CONCLUSIONS: The results of this study suggest that the CO-OP approach resulted in a positive therapeutic effect on self-selected occupational performance and daily and functional activities in individuals with chronic hemiparetic stroke. PMID: 30741705 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - February 13, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Publication trends in transcranial magnetic stimulation: a 30-year panorama
ConclusionThis study implemented a systematic, bibliometric approach to quantitively assess the breadth of the TMS literature base and identify temporal publication and authorship trends. Drawing on these insights may aid understanding of historical progress in TMS over the last 30 years and help identify into unmet needs and opportunities to improve scientific and publishing practices to contribute to the future health of the field. These findings are likely to be relevant to researchers, clinicians, funders, industry collaborators and other stakeholders.
Source: Brain Stimulation - January 18, 2019 Category: Neurology Source Type: research

ƒPublication trends in transcranial magnetic stimulation: a 30-year panorama
ConclusionThis study implemented a systematic, bibliometric approach to quantitively assess the breadth of the TMS literature base and identify temporal publication and authorship trends. Drawing on these insights may aid understanding of historical progress in TMS over the last 30 years and help identify into unmet needs and opportunities to improve scientific and publishing practices to contribute to the future health of the field. These findings are likely to be relevant to researchers, clinicians, funders, industry collaborators and other stakeholders.
Source: Brain Stimulation - January 10, 2019 Category: Neurology Source Type: research

Links Between Strokes and Hereditary Hemorrhagic Telangiectasia: A Population-Based Study.
This study found a higher HHT prevalence in Alberta (1 in 3800) compared to the world average of 1 in 5000. Women were also more likely to be diagnosed with HHT, with a 3.25:1 female gender preponderance in the yearly incidence.InterpretationThis study not only shows that HHT patients are at higher risk of having a stroke but also quantifies that risk using an age-adjusted metric in Alberta. This province has a higher than expected disease burden of HHT, with the majority of cases affecting women. Our study found that acute ischemic strokes and transient ischemic attacks are far more common than hemorrhage in HHT. As HHT i...
Source: The Canadian Journal of Neurological Sciences - December 6, 2018 Category: Neurology Authors: Chowdhury FN, Chandrarathne GS, Masilamani KD, LaBranche JTN, Malo S, Svenson LW, Jeerakathil T, Vethanayagam DP Tags: Can J Neurol Sci Source Type: research

Effects on balance skills and patient compliance of biofeedback training with inertial measurement units and exergaming in subacute stroke: a pilot randomized controlled trial.
Authors: Lupo A, Cinnera AM, Pucello A, Iosa M, Coiro P, Personeni S, Gimigliano F, Iolascon G, Paolucci S, Morone G Abstract Stroke patients have reduced balance and postural control that limits their activities of daily living and participation in social life. Recently, many exergaming systems based on video-biofeedback have been developed for balance training in neurological conditions, however their efficacy remains to be proven. The aim of this study was to investigate the effects on balance skills and patient compliance of biofeedback training based on inertial measurement units and exergaming in subacute str...
Source: Functional Neurology - November 22, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Evidence of Concomitantly Increasing Stroke and Dementia Prevalence among those 80 Years and Older in Ontario, Canada, 2003-04 to 2012-13.
This study aimed to report the concurrent temporal trends of stroke and dementia prevalence in Ontario among the same age demographic. The prevalence of both stroke and dementia increased from 2003-04 to 2012-13 in both sexes and the magnitude in which prevalence of dementia increased over time exceeded that of stroke. The substantial increase in the prevalence of dementia may be because of increased recognition and diagnoses of dementia and increased survival of stroke patients who are at higher risk of developing dementia. PMID: 30449286 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - November 19, 2018 Category: Neurology Authors: Cerasuolo JO, Azarpazhooh MR, Kapral MK, Cipriano LE, Hachinski V Tags: Can J Neurol Sci Source Type: research

Screening Adherence for Depression Post Stroke: Evaluation of Outpatients, a London Experience (SAD PEOPLE).
CONCLUSION: This study highlights the frequency of depressive symptoms in an outpatient cohort and demonstrates how screening rates can be improved by using a standardized form. Routine PHQ-9 completion at the first outpatient visit was associated with more physician-patient discussion and documentation regarding mood. PMID: 30346909 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 22, 2018 Category: Neurology Authors: MacKenzie HM, Rice D, Teasell R, Macaluso S Tags: Top Stroke Rehabil Source Type: research

Stroke and Coronary Artery Disease Are Associated With Parkinson's Disease.
CONCLUSIONS: Our study suggested that stroke and CAD are associated with PD in two Chinese population-based cohorts, indicating a probable vascular component in the pathogenesis of PD. PMID: 30001757 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - July 13, 2018 Category: Neurology Authors: Li Q, Wang C, Tang H, Chen S, Ma J Tags: Can J Neurol Sci Source Type: research

Long-Term Outcomes in the Management of Central Neuropathic Pain Syndromes: A Prospective Observational Cohort Study.
CONCLUSION: Patients with central neuropathic pain syndromes managed in tertiary care centers were less likely to achieve a meaningful improvement in pain and function compared with patients with peripheral neuropathic pain at 12-month follow-up. PMID: 29996953 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - July 12, 2018 Category: Neurology Authors: Staudt MD, Clark AJ, Gordon AS, Lynch ME, Morley-Forster PK, Nathan H, Smyth C, Stitt LW, Toth C, Ware MA, Moulin DE Tags: Can J Neurol Sci Source Type: research

Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial
This report presents a secondary analysis, and follow-up is complete.FindingsBetween May, 2001, and October, 2008, 1713 patients were enrolled and randomly allocated treatment (855 were assigned stenting and 858 endarterectomy), of whom 1530 individuals were followed up with ultrasound (737 assigned stenting and 793 endarterectomy) for a median of 4·0 years (IQR 2·3–5·0). At least moderate restenosis (≥50%) occurred in 274 patients after stenting (cumulative 5-year risk 40·7%) and in 217 after endarterectomy (29·6%; unadjusted hazard ratio [HR] 1·43, 95% CI 1·21–1·72; p<0·0001). Patients with at least mo...
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study
Publication date: June 2018Source: The Lancet Neurology, Volume 17, Issue 6Author(s): Cyril Pottier, Xiaolai Zhou, Ralph B Perkerson, Matt Baker, Gregory D Jenkins, Daniel J Serie, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Adolfo López de Munain, Miren Zulaica, Fermin Moreno, Isabelle Le Ber, Florence Pasquier, Didier Hannequin, Raquel Sánchez-Valle, Anna Antonell, Albert Lladó, Tammee M Parsons, NiCole A FinchSummaryBackgroundLoss-of-function mutations in GRN cause frontotemporal lobar degeneration (FTLD). Patients with GRN mutations present with a uniform subtype of TAR DNA-binding protein 43 (TDP-43) patholog...
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial
This report presents a secondary analysis, and follow-up is complete.FindingsBetween May, 2001, and October, 2008, 1713 patients were enrolled and randomly allocated treatment (855 were assigned stenting and 858 endarterectomy), of whom 1530 individuals were followed up with ultrasound (737 assigned stenting and 793 endarterectomy) for a median of 4·0 years (IQR 2·3–5·0). At least moderate restenosis (≥50%) occurred in 274 patients after stenting (cumulative 5-year risk 40·7%) and in 217 after endarterectomy (29·6%; unadjusted hazard ratio [HR] 1·43, 95% CI 1·21–1·72; p<0·0001). Patients with at least mo...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research

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