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Specialty: Allergy & Immunology
Therapy: Immunotherapy

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Total 550 results found since Jan 2013.

The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses
AbstractPurpose of ReviewImmunoglobulin A (IgA) mediates immune exclusion of antigens in the gut. Notably, IgA plays also a role in the prevention of IgE-mediated allergies and induction of immune tolerance. The present review addresses the role of IgA in the manifestation of IgE-mediated allergies, including allergen-specific immunotherapy (AIT), the regulation of IgA production, and the mechanism of IgA in immune cell activation.Recent FindingsThe majority of studies report an association of IgA with the induction of immune tolerance in IgE-mediated allergies. However, reports on the involvement of humoral and mucosal Ig...
Source: Current Allergy and Asthma Reports - September 19, 2023 Category: Allergy & Immunology Source Type: research

Modulation of immune response by nanoparticle-based immunotherapy against food allergens
The increasing prevalence of food allergies worldwide and the subsequent life-threatening anaphylactic reactions often have sparse treatment options, providing only symptomatic relief. Great strides have been made in research and in clinics in recent years to offer novel therapies for the treatment of allergic disorders. However, current allergen immunotherapy has its own shortcomings in terms of long-term efficacy and safety, due to the local side effects and the possibility of anaphylaxis. Allergen-specific immunotherapy is an established therapy in treating allergic asthma, allergic rhinitis, and allergic conjunctivitis...
Source: Frontiers in Immunology - September 8, 2023 Category: Allergy & Immunology Source Type: research

SQ HDM sublingual immunotherapy tablet for the treatment of HDM allergic rhinitis and asthma improves subjective sleepiness and insomnia: an exploratory analysis of the real-life CARIOCA study
CONCLUSION: In patients with HDM AR and/or asthma associated sleep disorders, an improvement in subjective insomnia and sleepiness was observed after one year of treatment with the SQ HDM SLIT-tablet in a real-life setting.PMID:37669078 | DOI:10.18176/jiaci.0934
Source: Journal of Investigational Allergology and Clinical Immunology - September 5, 2023 Category: Allergy & Immunology Authors: D Jaffuel E Serrano C Leroyer A Chartier P Demoly Source Type: research

The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses
AbstractPurpose of ReviewImmunoglobulin A (IgA) mediates immune exclusion of antigens in the gut. Notably, IgA plays also a role in the prevention of IgE-mediated allergies and induction of immune tolerance. The present review addresses the role of IgA in the manifestation of IgE-mediated allergies, including allergen-specific immunotherapy (AIT), the regulation of IgA production, and the mechanism of IgA in immune cell activation.Recent FindingsThe majority of studies report an association of IgA with the induction of immune tolerance in IgE-mediated allergies. However, reports on the involvement of humoral and mucosal Ig...
Source: Current Allergy and Asthma Reports - August 23, 2023 Category: Allergy & Immunology Source Type: research

Anti-allergen monoclonal antibodies for the treatment of allergies
ConclusionThe development of anti-allergen antibody therapies offers great potential for the treatment of allergies. Of interest, the efficacy of passive immunization approaches will likely extend beyond allergen neutralization as in the presence of the allergen they might contribute to long-lasting disease modification.
Source: Allergo Journal International - August 15, 2023 Category: Allergy & Immunology Source Type: research

Update on oral and epicutaneous immunotherapy for children with food allergy
ConclusionThe implementation of recent treatment protocols has significantly improved the safety of OIT. Therefore, its continuation using safety protocols can be considered in the selection of the optimal OIT for individual patients, as provision of safe and effective treatment is crucial for the success of OIT.
Source: Allergo Journal International - July 11, 2023 Category: Allergy & Immunology Source Type: research

Potential role for oral tolerance in gene therapy
Cell Immunol. 2023 Jun 28:104742. doi: 10.1016/j.cellimm.2023.104742. Online ahead of print.ABSTRACTOral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic lettuce cells. Here, we find that this approach substantially reduces antibody development against factor VIII in hemophili...
Source: Cellular Immunology - July 9, 2023 Category: Allergy & Immunology Authors: John S S Butterfield Xin Li Sreevani Arisa Kwang-Chul Kwon Henry Daniell Roland W Herzog Source Type: research

Allergen ‐specific immunotherapy by recombinant Der P1 allergen‐derived peptide‐based vaccine in an allergic mouse model
ConclusionThe use of present available recombinant proteins is considered a viable, cost-effective, and long-term option for providing effective HDM allergy immunotherapy vaccines without side effects.
Source: Immunity, Inflammation and Disease - June 9, 2023 Category: Allergy & Immunology Authors: Soheila Asoudeh Moghanloo, Mohsen Forouzanfar, Mojtaba Jafarinia, Mohammad R. Fazlollahi, Gholam Ali Kardar Tags: ORIGINAL ARTICLE Source Type: research

Allergen immunotherapy: progress and future outlook
Expert Rev Clin Immunol. 2023 Apr 30. doi: 10.1080/1744666X.2023.2209319. Online ahead of print.ABSTRACTINTRODUCTION: Allergy, the immunological hypersensitivity to innocuous environmental compounds, is a global health problem. The disease triggers, allergens, are mostly proteins contained in various natural sources such as plant pollen, animal dander, dust mites, foods, fungi and insect venoms. Allergies can manifest with a wide range of symptoms in various organs, and be anything from just tedious to life-threatening. A majority of all allergy patients are self-treated with symptom-relieving medicines, while allergen imm...
Source: Expert Review of Clinical Immunology - April 30, 2023 Category: Allergy & Immunology Authors: Lara Šošić Marta Paolucci Stephan Flory Fadi Jebbawi Thomas M K ündig P ål Johansen Source Type: research