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Procedure: Transplants
Therapy: Stem Cell Therapy
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Total 102 results found since Jan 2013.
Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
CONCLUSIONS: AT-MSCs could be safely administered to our pediatric cases with BoS post-allo-HSCT. Considering their advanced stage of disease, their sub-optimal functional capacity due to steroid-induced complications, and COVID-19 infection post-treatment, we believe that AT-MSC therapy can have possible efficacy in the management of pediatric BoS. The conduction of further studies with larger sample sizes and more frequent injections is prudent for further optimization of AT-MSC therapy against BoS. Trial registration Iranian Registry of Clinical Trials (IRCT), IRCT20201202049568N2. Registered 22 February 2021, https://e...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Rashin Mohseni Pouya Mahdavi Sharif Maryam Behfar Mohammad Reza Modaresi Rohola Shirzadi Mahta Mardani Leila Jafari Fahimeh Jafari Zeynab Nikfetrat Amir Ali Hamidieh Source Type: research
Cutting-edge regenerative therapy for Hirschsprung disease and its allied disorders
AbstractHirschsprung disease (HSCR) and its associated disorders (AD-HSCR) often result in severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy. Notably, HSCR involving the small intestine, isolated hypoganglionosis, chronic idiopathic intestinal pseudo-obstruction, and megacystis-microcolon-intestinal hypoperistalsis syndrome carry a poor prognosis. Ultimately, small-bowel transplantation (SBTx) is necessary for refractory cases, but it is highly invasive and outcomes are less than optimal, despite advances in surgical techniques and management. Thus, regenerative therapy has come to light as...
Source: Surgery Today - September 5, 2023 Category: Surgery Source Type: research
Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients – a pilot study for novel biomarker and risk stratification determination
ConclusionAllogeneic stem-cell transplantation is associated with immune system vulnerability due to conditioning, increased inflammation and fatigue, and loss of muscle strength and function. In addition to hsCRP, Kynurenine seems to be a reliable biomarker to monitor acute and regenerative inflammation status of alloSCT patients, while Musclin and Galectin-3 may be added to physiological assessment regarding myopathy and sarcopenia. Grip strength and daily activity level should be documented by professionals to identify risk patients early and support them with optimal (exercise) therapy.
Source: Frontiers in Immunology - May 15, 2023 Category: Allergy & Immunology Source Type: research
A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease
Chronic graft-versus-host disease (cGVHD) is the most common cause of late morbidity and non-relapse mortality among patients who have undergone allogeneic hematopoietic stem cell transplantation (HCT).1 The presentation of cGVHD is highly heterogeneous and may involve multiple organ systems, often leading to detrimental impacts on quality of life and functional status.2,3 Standard first-line treatment involves prolonged systemic steroids, which can be complicated by numerous steroid-related toxicities including hyperglycemia, myopathy, and osteoporosis.
Source: Biology of Blood and Marrow Transplantation - December 24, 2022 Category: Hematology Authors: Chenyu Lin, Rachel A. DiCioccio, Tarek Haykal, William C. McManigle, Zhiguo Li, Sarah M. Anand, Jonathan C. Poe, Sonali J. Bracken, Wei Jia, Edwin P. Alyea, Adela R. Cardones, Taewoong Choi, Cristina Gasparetto, Michael R. Grunwald, Therese Hennig, Yubin Tags: AMA Source Type: research
Clinicopathologic Profiles of Sporadic Late-Onset Nemaline Myopathy: Practical Importance of Anti-{alpha}-Actinin Immunostaining
Discussion
SLONM is a treatable myopathy with ASCT or traditional immunotherapy, especially when combined with steroids and immunosuppressants. Anti–α-actinin immunostaining is the most reliable pathologic marker to identify rod-bearing fibers, and it should be performed routinely in adult patients with undiagnosed nonnecrotic myopathies.
Source: Neurology Neuroimmunology and Neuroinflammation - May 17, 2022 Category: Neurology Authors: Zhao, B., Dai, T., Zhao, D., Ma, X., Zhao, C., Li, L., Sun, Y., Zhang, Y., Yan, Y., Lu, J.-Q., Liu, F., Yan, C. Tags: MRI, All Immunology, Autoimmune diseases, All Clinical Neurology, Muscle disease Research Article Source Type: research
Drug ‐Drug Interaction of Letermovir and Atorvastatin in Healthy Participants
AbstractLetermovir (MK-8228/AIC246) is a cytomegalovirus (CMV) DNA terminase complex inhibitor for CMV prophylaxis in adult patients undergoing hematopoietic stem cell transplant. It is cytochrome P450 (CYP) 3A inhibitor and inhibits organic anion transporting polypeptide 1B1/3 and breast cancer resistance protein transporters. Atorvastatin (ATV), a commonly used treatment for hypercholesterolemia, is a substrate of organic anion transporting polypeptide 1B1, potentially breast cancer resistance protein, and CYP3A. As letermovir may be coadministered with ATV, the effect of multiple-dose letermovir 480 mg once daily on t...
Source: Clinical Pharmacology in Drug Development - February 14, 2022 Category: Drugs & Pharmacology Authors: Jacqueline B. McCrea,
Karsten Menzel,
Adedayo Adedoyin,
Carolyn R. Cho,
Sabrina Fox ‐Bosetti,
Sreeraj Macha,
Tian Zhao,
Fang Liu,
Deborah Panebianco,
S. Aubrey Stoch,
Marian Iwamoto Tags: Original Article Source Type: research
Drug-Drug Interaction of Letermovir and Atorvastatin in Healthy Participants
Clin Pharmacol Drug Dev. 2022 Feb 14. doi: 10.1002/cpdd.1071. Online ahead of print.ABSTRACTLetermovir (MK-8228/AIC246) is a cytomegalovirus (CMV) DNA terminase complex inhibitor for CMV prophylaxis in adult patients undergoing hematopoietic stem cell transplant. It is cytochrome P450 (CYP) 3A inhibitor and inhibits organic anion transporting polypeptide 1B1/3 and breast cancer resistance protein transporters. Atorvastatin (ATV), a commonly used treatment for hypercholesterolemia, is a substrate of organic anion transporting polypeptide 1B1, potentially breast cancer resistance protein, and CYP3A. As letermovir may be coad...
Source: Clinical Genitourinary Cancer - February 14, 2022 Category: Cancer & Oncology Authors: Jacqueline B McCrea Karsten Menzel Adedayo Adedoyin Carolyn R Cho Sabrina Fox-Bosetti Sreeraj Macha Tian Zhao Fang Liu Deborah Panebianco S Aubrey Stoch Marian Iwamoto Source Type: research
Novel GNE Gene Variants Associated with Severe Congenital Thrombocytopenia and Platelet Sialylation Defect
Thromb Haemost. 2022 Jan 20. doi: 10.1055/s-0041-1742207. Online ahead of print.ABSTRACTThe GNE gene encodes an enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid, a precursor of sialic acids. GNE mutations are classically associated with Nonaka myopathy and sialuria, following an autosomal recessive and autosomal dominant inheritance pattern. Reports show that single GNE variants cause severe thrombocytopenia without muscle weakness. Using panel sequencing, we identified two novel compound heterozygous variants in GNE in a young girl with life-threatening bleedings, severe congenital thrombocy...
Source: Thrombosis and Haemostasis - January 20, 2022 Category: Hematology Authors: Barbara Zieger Doris Boeckelmann Waseem Anani Herv é Falet Jieqing Zhu Hannah Glonnegger Hermann Full Felicia Andresen Miriam Erlacher Ekkehart Lausch Salome Fels Brigitte Strahm Peter Lang Karin M Hoffmeister Source Type: research
A case of sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance: long-term observation of neurological symptoms after autologous stem-cell transplantation
Nagoya J Med Sci. 2021 Aug;83(3):641-647. doi: 10.18999/nagjms.83.3.641.ABSTRACTA 47-year-old woman presented with progressive limb weakness. A neurological examination revealed proximal dominant symmetrical muscle weakness in her limbs, and electromyography revealed complex repetitive discharges and short motor unit potentials with positive sharp waves in the biceps. We observed early recruitment in the quadriceps, and laboratory tests revealed normal creatine kinase. Serum protein electrophoresis showed monoclonal IgG-lambda, but the bone marrow aspiration specimen was normal. A muscle biopsy revealed nemaline rod accumu...
Source: Nagoya Journal of Medical Science - September 23, 2021 Category: International Medicine & Public Health Authors: Takashi Ando Takahiko Sato Shingo Kurahashi Yuka Kawaguchi Yusuke Kagaya Yukiyasu Ozawa Satoko Hirano Yoji Goto Kazuo Mano Satoshi Yokoi Tomohiko Nakamura Ayuka Murakami Seiya Noda Seigo Kimura Jun Sone Satoshi Kuru Gen Sobue Masahisa Katsuno Source Type: research
