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Total 203 results found since Jan 2013.

A Systematic Review and Metaanalysis of Predictors of Mortality in Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease
CONCLUSION: Many mortality risk factors were identified, though heterogeneity was high, with a low quality of evidence and a risk of publication bias. Studies regarding anti-MDA5 antibody-positive disease and and those from East Asia predominate, which could mask risk factors relevant to other IIM subgroups or populations.PMID:36379584 | DOI:10.3899/jrheum.220383
Source: J Rheumatol - November 15, 2022 Category: Rheumatology Authors: Jennifer Hannah Huiyi E Law Tanya Gordon Michael Rooney April Buazon Maryam Adas Deepak Nagra Christopher Stovin James Galloway Patrick Gordon Source Type: research

New-onset dermatomyositis following COVID-19: A case report
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Most of the infected individuals have recovered without complications, but a few patients develop multiple organ involvements. Previous reports suggest an association between COVID-19 and various inflammatory myopathies, in addition to autoimmune diseases. COVID-19 has been known to exacerbate preexisting autoimmune diseases and trigger various autoantibodies and autoimmune disease occurrence. Here we report a case of complicated COVID-19 with anti-synthetase autoantibodies (ASSs) presenting ...
Source: Frontiers in Immunology - October 24, 2022 Category: Allergy & Immunology Source Type: research

Progression and prognosis of interstitial pneumonia with autoimmune features: a longitudinal, prospective, multi-centre study
CONCLUSIONS: IPAF patients had a rate of progression towards SAD similar to that reported in previous studies on undifferentiated connective tissue diseases, thus including some patients in which lung involvement could represent the first or even the sole clinical manifestation of a SAD.PMID:36189910 | DOI:10.55563/clinexprheumatol/lycdca
Source: Clinical and Experimental Rheumatology - October 3, 2022 Category: Rheumatology Authors: Gianluca Sambataro Domenico Sambataro Lucia Spicuzza Federica Meloni Giorgio Lorini Lorenzo Malatino Michele Colaci Giandomenico Sebastiani Annamaria Iuliano Claudia Canofari Fabrizio Luppi Giovanni Franco Umberto Zanini Andreina Manfredi Filippo Gozzi Ma Source Type: research

Immune checkpoint inhibitor therapy in a patient with small cell lung cancer and anti ‐transcriptional intermediary factor 1‐γ antibody‐positive dermatomyositis: A case report
Autoimmune diseases (ADs) such as dermatomyositis (DM) are closely related to cancers. Although there are concerns that immune checkpoint inhibitors (ICIs) may cause immune-related adverse events or exacerbate ADs, clinicians should consider ICIs for SCLC patients with DM because the treatment of malignancy by ICIs improves the symptoms of paraneoplastic AD. AbstractAutoimmune diseases (ADs) are closely related to cancers; 30% of dermatomyositis (DM) cases are associated with malignancy. In lung cancer patients accompanied by DM, the most frequent cancer type is small cell lung cancer (SCLC). Anti-transcriptional intermedi...
Source: Thoracic Cancer - August 19, 2022 Category: Cancer & Oncology Authors: Yoonjoo Kim, Dongil Park, Song ‐Yi Choi, Chaeuk Chung Tags: CASE REPORT Source Type: research

Myopathy associated with anti-signal recognition particle antibodies with pulmonary involvement and response to rituximab
AbstractThe authors present the case of a 76-year-old female patient with progressive decrease in proximal muscle strength, fatigue, dyspnea, diffuse hand edema and painful triphasic Raynaud ’s phenomenon. Anti-SRP and anti-SSA antibodies were detected, muscle biopsy revealed changes consistent with necrotizing myopathy and capillaroscopy had findings compatible with systemic sclerosis. High-resolution chest computed tomography revealed interstitial lung disease with a non-specific in terstitial pneumonia pattern. Lung function tests demonstrated a forced vital capacity 93% and a diffusing capacity for carbon monoxide of...
Source: Rheumatology International - June 18, 2022 Category: Rheumatology Source Type: research

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome mimicking herpes simplex encephalitis: A case report
Radiol Case Rep. 2022 May 8;17(7):2428-2431. doi: 10.1016/j.radcr.2022.04.019. eCollection 2022 Jul.ABSTRACTMitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presents with the features of herpes simplex encephalitis (HSE), which is rare and has been described in only a few case reports. Our case describes a 17-year-old female with no significant previous medical history presenting with an acute onset of fever, headache, and epilepsy, similar to HSE. Computed tomography of the brain showed bilateral basal ganglia calcification. Magnetic resonance imaging demonstrated gyriform...
Source: Herpes - May 23, 2022 Category: Infectious Diseases Authors: Wen-Gao Zeng Wan-Min Liao Jue Hu Su-Fen Chen Zhen Wang Source Type: research

The role of multimodality imaging in patients with heart failure with reduced and preserved ejection fraction
Purpose of review The burden of clinical heart failure, both heart failure with a reduced ejection fraction (HFrEF) and with a preserved ejection fraction (HFpEF), continues to increase both nationally and globally. This review summarizes the expanding role of multimodality imaging techniques in the evaluation and management these patients. Recent findings Echocardiographic assessment for heart failure continues to expand and should include a robust hemodynamic and strain assessment. Nuclear techniques have also continued to evolve and advances including computed tomography attenuation correction for single phot...
Source: Current Opinion in Cardiology - May 1, 2022 Category: Cardiology Tags: HEART FAILURE: Edited by Jerry Estep Source Type: research

Idiopathic inflammatory myopathies: CT characteristics of interstitial lung disease and their association(s) with myositis-specific autoantibodies
ConclusionDespite the observed IIM heterogeneity, CT-scan criteria enabled ILD assignment to the three clusters, which were associated with MSAs. Radiologist identification of those clusters could facilitate diagnostic screening and therapeutics.Summary statementInterstitial lung disease in patients with idiopathic inflammatory myopathy could be classified into three clusters according to CT-scan criteria, and these clusters were significantly associated with myositis-specific autoantibodies.Key Points•Cluster analysis discerned three homogeneous groups of interstitial lung disease (ILD) for which cysts, consolidations, ...
Source: European Radiology - April 26, 2022 Category: Radiology Source Type: research