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Total 243 results found since Jan 2013.

HIV plus HPV leads to increased anal cancer risk in men
This study highlights the benefit of adhering to HIV treatment, which among HIV-infected men who have sex with men, is important for cancer-prevention strategies," Wiley said.   The next step in this research is to begin looking at ways to develop better, more effective HPV infection–prevention strategies, including vaccination for age-eligible males and screening and treatment programs for high-risk men who have sex with men to prevent invasive cancers.   "Right now, we perform colonoscopies to prevent colon cancer, where 53 men per 100,000 are diagnosed annually," Wiley said. "Unfortunately, we do not p...
Source: UCLA Newsroom: Health Sciences - December 2, 2013 Category: Universities & Medical Training Source Type: news

A shorter interval between menarche and first sexual intercourse is associated with increased risk of high-grade cervical disease
Commentary on: Ruiz AM, Ruiz JE, Gavilanes AV, et al.. for the FUTURE I and II Study Group. Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease. J Infect Dis 2012;206:1887–96. Implications for practice and research Female adolescents with a shorter duration between the age of menarche and first sexual intercourse are at an increased risk of high-grade cervical disease. Clinical counselling should include clear recommendations to obtain human papillomavirus (HPV) vaccination well before first intercourse to reduce the future risk of high-grade cervical lesions among sexually na&i...
Source: Evidence-Based Nursing - December 10, 2013 Category: Nursing Authors: Smith, J. S. Tags: Sexual transmitted infections (bacterial), Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Cervical cancer, Contraception, Drugs: obstetrics and gynaecology, Reproductive medicine, Gynecological cancer, Ophthalmolog Source Type: research

Measles reported near Boston
Measles under a microscope Two cases of measles, the highly contagious virus, have been confirmed just outside of Boston, according Massachusetts Department of Public Health. Later reports traced the disease to a Framingham Trader Joe’s shopping market. And while most people in the United States have received vaccines against the disease, or got it and recovered as children making them immune, health officials are advising anyone displaying any symptoms to call a doctor. (It’s not recommended you go to a health care facility, out of fear you may infect others who have not been vaccinated.) Many adults associate me...
Source: Thrive, Children's Hospital Boston - February 25, 2014 Category: Pediatrics Authors: Lisa Fratt Tags: All posts infecious disease measles Parenting Source Type: news

Coadministration of Antigen-conjugated and Free CpG: Effects of in Vitro and in Vivo Interactions in a Murine Model.
Abstract CpG oligodeoxynucleotides (CpG) are widely studied as promising adjuvants in vaccines against a range of diseases including infection, cancer or allergy. Conjugating antigen to CpG has been shown to potentiate the adjuvant effect via enhancing antigen uptake and danger signaling by the very same cell. In the present study, using biotinylated CpG and streptavidin as a model system, we demonstrate that CpG motif containing free and antigen-conjugated oligonucleotides do not compete in terms of cell activation via TLR9, but do compete for cellular uptake. Antigen-conjugated CpG enhances cellular association ...
Source: Immunology Letters - February 21, 2014 Category: Allergy & Immunology Authors: Herbáth M, Szekeres Z, Kövesdi D, Papp K, Erdei A, Prechl J Tags: Immunol Lett Source Type: research

Seattle BioMed gets $9.8M grant to develop HIV/AIDS vaccine
Seattle BioMed said it's received a seven-year, $9.8 million grant from the National Institute of Allergy and Infectious Diseases (NIAID) to develop a vaccine targeting HIV/AIDS. Seattle BioMed said it will lead a consortium that includes the Rockefeller University, the University of Washington, Seattle Children's Hospital and the Fred Hutchinson Cancer Research Center. According to South Lake Union-based Seattle BioMed, the grant will help "develop a vaccine that would elicit broadly neutralizing…
Source: bizjournals.com Health Care:Physician Practices headlines - March 10, 2014 Category: American Health Authors: Ben Miller Source Type: research

Five to seven years after breast cancer treatment, over a third of women (37%) report persistent pain
This study highlights the importance of persistent and late effects of cancer therapy on the lives of survivors and identified fluctuating pattern of symptoms over time. The findings of persistent pain and sensory disturbances at an average of 6 years following primary breast cancer therapy underscore the significance of long-term treatment effects. Younger age and axillary lymph node dissection were reported as risk factors for persistent pain. Patients with these risk factors should be targeted in clinical practice for assessment and early intervention. The study findings provide strong support for individualising c...
Source: Evidence-Based Nursing - March 14, 2014 Category: Nursing Authors: Knobf, T. Tags: Adult nursing, Immunology (including allergy), Vaccination / immunisation, Pain (neurology), Reproductive medicine, Breast cancer, Radiotherapy, Breast surgery, Surgical oncology, Drugs: endocrine system Source Type: research

Improving DNA vaccine performance through vector design.
Abstract DNA vaccines are a rapidly deployed next generation vaccination platform for treatment of human and animal disease. DNA delivery devices, such as electroporation and needle free jet injectors, are used to increase gene transfer. This results in higher antigen expression which correlates with improved humoral and cellular immunity in humans and animals. This review highlights recent vector and transgene design innovations that improve DNA vaccine performance. These new vectors improve antigen expression, increase plasmid manufacturing yield and quality in bioreactors, and eliminate antibiotic selection and...
Source: Current Gene Therapy - August 26, 2014 Category: Genetics & Stem Cells Authors: Williams JA Tags: Curr Gene Ther Source Type: research

DNA vaccines against influenza.
Abstract Genetic vaccine technology has been considerably developed within the last two decades. This cost effective and promising strategy can be applied for therapy of cancers and for curing allergy, chronic and infectious diseases, such as a seasonal and pandemic influenza. Despite numerous advantages, several limitations of this technology reduce its performance and can retard its commercial exploitation in humans and its veterinary applications. Inefficient delivery of the DNA vaccine into cells of immunized individuals results in low intracellular supply of suitable expression cassettes encoding an antigen, ...
Source: Acta Biochim Pol - September 12, 2014 Category: Biochemistry Authors: Stachyra A, Góra-Sochacka A, Sirko A Tags: Acta Biochim Pol Source Type: research

Immunisation against HPV in girls with intellectual disabilities
Since September 2008 in the UK, immunisation against human papillomavirus (HPV) has been routinely offered to all girls aged 12–13 years as part of the childhood immunisation programme. It has been shown in previous research, that children attending schools for children and young people with intellectual disability are less likely to receive routine vaccines compared with non-disabled peers.1 Unpublished data from an audit carried out in the Portsmouth district suggests similar issues for HPV vaccination. This paper looks at what we know about HPV infection and the risks to individuals with intellectual disabili...
Source: Archives of Disease in Childhood - November 13, 2014 Category: Pediatrics Authors: MacLeod, R., Tuffrey, C. Tags: Oncology, Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Cervical cancer, Cervical screening, Adolescent health, Child and adolescent psychiatry (paedatrics), Child health, Disability, Screen Source Type: research

HPV vaccine rates perpetuate racial and geographic cancer disparities
SAN ANTONIO – Girls who live in states with higher rates of cervical cancer incidence and mortality are less likely to receive the human papilloma virus vaccine, researchers reported at a meeting on disparities in cancer health care held by the American Association for Cancer...
Source: Skin and Allergy News - November 11, 2014 Category: Dermatology Tags: FPN Journals FPN News FPN Child & Adolescent Medicine FPN Infectious Diseases IMN Journals IMN News Source Type: news

Failure to Identify HIV-Infected Individuals in a Clinical Trial Using a Single HIV Rapid Test for Screening
Conclusions: In clinical trials, HIV infections can be missed for a variety of reasons. Using more than one assay to screen for HIV infection may reduce the number of missed infections. Content Type Journal ArticleCategory Original ArticlePages 62-68DOI 10.1310/hct1502-62Authors Estelle Piwowar-Manning, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MarylandJessica M. Fogel, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MarylandOliver Laeyendecker, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandShauna Wolf, Depa...
Source: HIV Clinical Trials - April 7, 2014 Category: Infectious Diseases Tags: HIV Clinical Trials Source Type: research

Vitamin D Receptor Signals Regulate Effector and Memory CD8 T Cell Responses to Infections in Mice Nutritional Immunology
Conclusion: Our data show a previously unrecognized impact of vitamin D deficiency on the quantity, quality, breadth, and location of CD8 T cell immunity to acute viral and bacterial infections.
Source: Journal of Nutrition - November 19, 2014 Category: Nutrition Authors: Yuzefpolskiy, Y., Baumann, F. M., Penny, L. A., Studzinski, G. P., Kalia, V., Sarkar, S. Tags: Nutritional Immunology Source Type: research

Newly approved Gardasil 9 vaccine adds 20% more coverage against cervical cancer
The Food and Drug Administration has approved a new version of the Gardasil vaccine that protects against five more human papillomavirus types that cause about 20% of cervical cancers, the agency announced on Dec. 10. The new vaccine, which is called Gardasil 9, “has the potential to prevent...googletag.display('div-gpt-ad-cta');
Source: Skin and Allergy News - December 10, 2014 Category: Dermatology Tags: FPN FDA & CDC FPN News FPN Child Adolescent Medicine FPN Men's Health FPN Women's Health IMN FDA IMN News IMN Adolescent Medicine Source Type: news

North Texas Fracking Zone Sees Growing Health Worries
This story was published by The Center for Public Integrity, a nonprofit, nonpartisan investigative news organization in Washington, D.C. DALLAS—Propped up on a hospital bed, Taylor Ishee listened as his mother shared a conviction that choked her up. His rare cancer had a cause, she believes, and it wasn’t genetics. Others in Texas have drawn the same conclusions about their confounding illnesses. Jana DeGrand, who suffered a heart attack and needed both her gallbladder and her appendix removed. Rebecca Williams, fighting off unexplained rashes, sharp headaches and repeated bouts of pneumonia. Maile Bush, who needed ...
Source: Science - The Huffington Post - December 11, 2014 Category: Science Source Type: news

Type-specific HPV prevalence in invasive cervical cancer in the UK prior to national HPV immunisation programme: baseline for monitoring the effects of immunisation
Conclusions The prevalence of HPV 16 and/or 18 was high in all UK countries and highest in those diagnosed at a younger age. The UK is well placed to monitor the impact of HPV vaccination on type-specific HPV prevalence in cervical disease.
Source: Journal of Clinical Pathology - January 20, 2015 Category: Pathology Authors: Mesher, D., Cuschieri, K., Hibbitts, S., Jamison, J., Sargent, A., Pollock, K. G., Powell, N., Wilson, R., McCall, F., Fiander, A., Soldan, K. Tags: Immunology (including allergy), Cervical cancer, Cervical screening, Gynecological cancer Original article Source Type: research