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Total 214 results found since Jan 2013.
Using imaging as a biomarker for asthma
There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, i...
Source: Journal of Allergy and Clinical Immunology - December 31, 2016 Category: Allergy & Immunology Authors: Abhaya Trivedi, Chase Hall, Eric A. Hoffman, Jason C. Woods, David S. Gierada, Mario Castro Tags: Reviews and feature article Source Type: research
The Generation R Study: design and cohort update 2017
AbstractThe Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their ...
Source: European Journal of Epidemiology - January 8, 2017 Category: Epidemiology Source Type: research
Cardiac magnetic resonance imaging for the diagnosis and follow-up of Loeffler's endocarditis
Loeffler's endocarditis (LE) is an acute form of primary restrictive cardiomyopathy. Patients affected often have a hypereosinophilic syndrome and cardiac involvement. Hypereosinophilia and cardiac involvement are also seen in the allergic eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Warfarin is generally indicated because of association between LE and embolic events.
Source: Journal of Allergy and Clinical Immunology - October 13, 2016 Category: Allergy & Immunology Authors: Grazia Casavecchia, Matteo Gravina, Michele Correale, Antonio Totaro, Luca Macarini, Matteo Di Biase, Natale Daniele Brunetti Tags: Letter to the Editor Source Type: research
Endoscopic endonasal nasopharyngectomy: tensor veli palatine muscle as a landmark for the parapharyngeal internal carotid artery
ConclusionThe PPICA was located in the same sagittal plane as the TVP muscle during dissection posteriorly. The PPICA appeared to lie around 2 cm laterally from the midline at around 2 cm in depth from the posterior margin of the TVP muscle. However, the exact position of the PPICA should be assessed using preoperative magnetic resonance imaging and intraoperative image‐guided systems.
Source: International Forum of Allergy and Rhinology - April 1, 2017 Category: Allergy & Immunology Authors: Chiung ‐Lin Liu, Ning‐I Hsu, Ping‐Hung Shen Tags: ORIGINAL ARTICLE Source Type: research
Immersive virtual reality as a teaching tool for neuroanatomy
ConclusionImmersive VR educational tools awarded a more positive learner experience and enhanced student motivation. However, the technology was equally as effective as the traditional text books in teaching neuroanatomy.
Source: International Forum of Allergy and Rhinology - July 1, 2017 Category: Allergy & Immunology Authors: Katelyn Stepan, Joshua Zeiger, Stephanie Hanchuk, Anthony Del Signore, Raj Shrivastava, Satish Govindaraj, Alfred Iloreta Tags: ORIGINAL ARTICLE Source Type: research
Phase 1 healthy volunteer willingness to participate and enrollment preferences.
CONCLUSION: Our results suggest that healthy volunteers are willing to participate in a wide range of types of phase 1 clinical trials, and express preferences for low risk and familiar studies and study procedures, preferences which are partially affected by offers of payment.
PMID: 28766409 [PubMed - as supplied by publisher]
Source: Clinical Trials - August 1, 2017 Category: Research Authors: Chen SC, Sinaii N, Bedarida G, Gregorio MA, Emanuel E, Grady C Tags: Clin Trials Source Type: research
MR Imaging of Mediastinal Masses
Abstract: The mediastinum contains vital vascular and nonvascular structures and organs, and a wide variety of abnormalities may arise from this region of the thorax. Although mediastinal masses may be initially detected on chest radiography, cross-sectional imaging plays an important role in the identification and evaluation of mediastinal lesions, enabling the formulation of focused differential diagnoses and ultimately guiding management. Computed tomography (CT) is considered the imaging modality of choice for evaluating most mediastinal masses; however, the role of magnetic resonance (MR) imaging continues to expand, ...
Source: Topics in Magnetic Resonance Imaging - August 1, 2017 Category: Radiology Tags: Review Articles Source Type: research
The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review
This article reviews the acute neural transmission of pain, pruritus, and nausea symptoms, which can begin in the periphery and/or viscera. The subsequent multiple pathways in the central nervous system that become involved in the processing of these symptoms are also discussed. The authors describe human brain imaging studies that have revealed consistent cortical and subcortical networks activated by these symptoms, including sensory, limbic, and associative regions. In particular, the authors discuss information revealed by the studies regarding the primary somatosensory cortex, secondary somatosensory cortex, anterio...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Neurologic Systems and Symptoms Neurology Pain Review central processing nausea pruritus Source Type: research
Acute hypopituitarism associated with periorbital swelling and cardiac dysfunction in a patient with pituitary tumor apoplexy: a case report
ConclusionsCommon causes of periorbital edema include infections, inflammation, trauma, allergy, kidney or cardiac dysfunction, and endocrine disorders such as primary hypothyroidism. In the present case, the patient ’s acute central hypothyroidism was probably involved in the development of both periorbital edema and cardiac dysfunction. The present case highlights the need for physicians to consider periorbital edema as an unusual predominant manifestation of pituitary tumor apoplexy.
Source: Journal of Medical Case Reports - August 24, 2017 Category: General Medicine Source Type: research
Assessing the clinical applicability of prior head imaging in patients with chronic rhinosinusitis
ConclusionPrior head imaging highly correlates to future maxillofacial CT in patients with chronic sinonasal complaints, and patients with prior negative scans are likely to remain negative on future imaging. If prior head scans exist, practitioners may want to avoid ordering additional scans in the absence of changing symptoms.
Source: International Forum of Allergy and Rhinology - November 1, 2017 Category: Allergy & Immunology Authors: Vidur Bhalla, Adam McCann, Kevin Sykes, Larry Hoover, D. David Beahm, Alexander Chiu Tags: ORIGINAL ARTICLE Source Type: research
Ventilation defect percent in helium-3 magnetic resonance imaging as a biomarker of severe outcomes in asthma
Imaging tools are of increasing interest in assessing patients with asthma for receipt of personalized therapy. Hyperpolarized (HP) 3He magnetic resonance imaging (MRI) of the lungs is one example of a functional lung imaging method that provides reproducible regional detection of ventilation defects in asthma.1 These ventilation defects are associated with areas of airway obstruction and air trapping.2 The most common metric for measuring defect extent is the ventilation defect percent (VDP).2-4 Here, we measure VDP using HP 3He MRI and compare VDP to asthma outcomes indicative of severe exacerbation, analogous to similar...
Source: Journal of Allergy and Clinical Immunology - November 9, 2017 Category: Allergy & Immunology Authors: David G. Mummy, Stanley J. Kruger, Wei Zha, Ronald L. Sorkness, Nizar N. Jarjour, Mark L. Schiebler, Loren C. Denlinger, Michael D. Evans, Sean B. Fain Tags: Letter to the Editor Source Type: research
Insight into the dynamic of gadolinium based contrast agent (GBCA) hypersensitivity: Acquisition, persistence and disappearance
Anaphylaxis against gadolinium based contrast agents (GBCAs) has been reported in all severity grades but is less frequent than hypersensitivity/allergy against iodinated contrast materials. Once a patient acquires such an adverse reaction a life-long premedication is usually the consequence in concert with GBCA-enhanced MR-imaging procedures. The usefulness of this prophylaxis has been questioned, and discussed controversially during the past. The herein presented case may shed some light into the dynamic of contrast-medium-induced hypersensitivity reactions.
Source: Magnetic Resonance Imaging - December 13, 2017 Category: Radiology Authors: Ingrid Boehm, Martin Hungerb ühler, Johannes T. Heverhagen Source Type: research
Diagnosing upper extremity deep vein thrombosis with non-contrast-enhanced Magnetic Resonance Direct Thrombus Imaging: A pilot study
Diagnosing upper extremity deep vein thrombosis (UEDVT) can be challenging. Compression ultrasonography is often inconclusive because of overlying anatomic structures that hamper compressing veins. Contrast venography is invasive and has a risk of contrast allergy. Magnetic Resonance Direct Thrombus Imaging (MRDTI) and Three Dimensional Turbo Spin-echo Spectral Attenuated Inversion Recovery (3D TSE-SPAIR) are both non-contrast-enhanced Magnetic Resonance Imaging (MRI) sequences that can visualize a thrombus directly by the visualization of methemoglobin, which is formed in a fresh blood clot.
Source: Thrombosis Research - January 10, 2018 Category: Hematology Authors: C.E.A. Dronkers, F.A. Klok, G.R. van Haren, J. Gleditsch, E. Westerlund, M.V. Huisman, L.J.M. Kroft Tags: Full Length Article Source Type: research
Diagnosis and endoscopic endonasal management of nontraumatic pseudoaneurysms of the cranial base
ConclusionSymptomatic cranial base pseudoaneurysms should undergo treatment to obliterate the aneurysm and relieve the mass effect. First, formal angiography is necessary for accurate diagnosis and treatment planning. Next, endovascular occlusion is performed, with a preference for coiling or endoluminal reconstruction with a flow diverter. Last, endoscopic intervention follows in cases where: (1) decompression of vital structures is indicated; (2) diagnosis of the pseudoaneurysm cannot be definitively confirmed with angiography; or (3) the etiology of the confirmed pseudoaneurysm requires further investigation.
Source: International Forum of Allergy and Rhinology - February 1, 2018 Category: Allergy & Immunology Authors: Daniel L. Faden, Marion A. Hughes, Philippe Lavigne, Brian T. Jankowitz, Eric W. Wang, Juan C. Fernandez ‐Miranda, Paul A. Gardner, Carl H. Snyderman Tags: ORIGINAL ARTICLE Source Type: research
Insight into the dynamic of gadolinium based contrast agent (GBCA) hypersensitivity: Acquisition, persistence and disappearance
Anaphylaxis against gadolinium based contrast agents (GBCAs) has been reported in all severity grades but is less frequent than hypersensitivity/allergy against iodinated contrast materials. Once a patient acquires such an adverse reaction a life-long premedication is usually the consequence in concert with GBCA-enhanced MR-imaging procedures. The usefulness of this prophylaxis has been questioned, and discussed controversially during the past. The herein presented case may shed some light into the dynamic of contrast-medium-induced hypersensitivity reactions.
Source: Magnetic Resonance Imaging - December 13, 2017 Category: Radiology Authors: Ingrid Boehm, Martin Hungerb ühler, Johannes T. Heverhagen Source Type: research
