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Total 472 results found since Jan 2013.
Outcomes of sinonasal squamous cell carcinoma with and without association of inverted papilloma: A multi-institutional analysis.
CONCLUSION: Although SCC with and without IP association are considered different diseases, their demographics and outcomes seem similar. Nodal metastasis was noted to be higher in the SCC cohort, which may indicate different tumor biology. Further study is warranted.
PMID: 28859706 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - September 1, 2017 Category: ENT & OMF Authors: Lobo BC, D'Anza B, Farlow JL, Tang D, Woodard TD, Ting JY, Sindwani R Tags: Am J Rhinol Allergy Source Type: research
Myeloid-derived Suppressor Cells Elimination by 5-Fluorouracil Increased Dendritic Cell-based Vaccine Function and Improved Immunity in Tumor Mice.
This study have shown that combinational therapy with DC vaccine improved immunity in tumor mice compared to the therapy consisting of DC vaccine or 5-FU only.
PMID: 29512369 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Khosravianfar N, Hadjati J, Namdar A, Boghozian R, Hafezi M, Ashourpour M, Kheshtchin N, Banitalebi M, Mirzaei R, Razavi SA Tags: Iran J Allergy Asthma Immunol Source Type: research
In Vitro Evaluation of CMV Specific CD8+T Cells Function in CMV+ Colorectal Cancer Patients Compared to Healthy Controls.
Abstract
The oncogenic role of human cytomegalovirus (HCMV) has been recently shown in different cancers like colorectal cancer (CRC). According to the recent immunotherapy approach to target the CMV-expressing tumor cells, we investigated the CMV peptide-stimulated CD8+T cells functions in CRC patients compared to healthy individuals. All sixteen patients and seven controls were CMV seropositive. Blood samples were obtained from patients without chemotherapy and radiotherapy before surgery. Cytotoxic CD8+ T cells were generated using 14-day culture of PBMCs in the presences of CMV peptide epitopes and rhIL-2. In...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 16, 2019 Category: Allergy & Immunology Authors: Shaker Ardakani M, Pak F, Kokhaei P, Fazeli MS, Shakiba Y, Tabatabaei Yazdi SM, Abbasian A, Nourizadeh M Tags: Iran J Allergy Asthma Immunol Source Type: research
Cytotoxicity Assessment and Apoptosis-related Gene Profiling of Antibody Treated Acute Myeloid Leukemia (AML) and Acute Lymphocytic Leukemia (ALL) Cancerous Cell Lines.
Abstract
Acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) are common acute leukemia in adults and children, respectively. In these malignancies, chemotherapy is the main treatment strategy that fails in many cases and is usually associated with adverse effects on healthy cells. In this regard, the development of new therapies is essential. Monoclonal antibodies directed to the cell surface markers of leukemic blasts may have promising consequences with minimal toxic effects on normal cells. Since cluster of differentiation 45Ra (CD45Ra) and CD123 antigens, two considered surface markers of leukemi...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 29, 2019 Category: Allergy & Immunology Authors: Habibi-Anbouhi M, Kafi Z, Ghazizadeh L, Kharazi S, Behdani M, Faraji F, Shokrgozar MA Tags: Iran J Allergy Asthma Immunol Source Type: research
Controversies in Allergy: Chemotherapy reactions, desensitize or de-label?
Publication date: Available online 14 August 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): David I. Hong, Ricardo Madrigal-Burgaleta, Aleena Banerji, Mariana Castells, Emilio Alvarez-Cuesta
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 16, 2020 Category: Allergy & Immunology Source Type: research
Controversies in Allergy: Chemotherapy Reactions, Desensitize, or Delabel?
Publication date: Available online 14 August 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): David I. Hong, Ricardo Madrigal-Burgaleta, Aleena Banerji, Mariana Castells, Emilio Alvarez-Cuesta
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 20, 2020 Category: Allergy & Immunology Source Type: research
Does Carboplatin Rapid Desensitization Change Its Adverse Drug Reactions Other than Hypersensitivity and Efficacy in Patients With Ovarian Cancer?
CONCLUSIONS: Rapid desensitization of carboplatin can lower the risk of immediate hypersensitivity reactions without changing the inherent effect and severe ADRs.
PMID: 32935494 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Delabeling Patients from Chemotherapy and Biologics Allergy: Implementing Drug Provocation Testing
Publication date: Available online 24 November 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Paula Vázquez-Revuelta, Jaume MartÃ-Garrido, Kevin Molina-Mata, Ramon Lleonart-Bellfill, Montserrat Rey-Salido Pharm, Ricardo Madrigal-Burgaleta
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 25, 2020 Category: Allergy & Immunology Source Type: research
Combination of 5-fluorouracil and Lipopolysaccharide Synergistically Induces Cytotoxicity and Apoptosis in MCF-7 Human Breast Cancer Cells.
Abstract
Several studies have been conducted to find suitable combinations of drugs to increase the efficacy of chemotherapy and reduce the resistance of tumor cells to treatment. Lipopolysaccharide (LPS), as a ligand for Toll-like receptor 4 (TLR-4), can modify immune responses in different cancers. Although multiple studies have been performed in this area, the effect of LPS on tumor cells remains controversial. In the present study, the cytotoxic effects of 5-fluorouracil (5-FU), with or without LPS, were evaluated in human breast cancer cell line (MCF-7) on apoptosis and gene expression in downstream signaling...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Nokhandani N, Naghavi Alhosseini M, Memarian A, Davoodi H Tags: Iran J Allergy Asthma Immunol Source Type: research
Drug allergy desensitization is not a unique recipe
Purpose of review
Drug desensitization is the only therapeutic option for patients with drug allergies who need to receive the drugs they are allergic to, and it is especially critical in patients with an urgent need for chemotherapy, biologics, or antibiotics, where equally effective alternatives might not be available. However, drug desensitization is not a cookbook where anyone with no experience or specific training can find a general recipe. This review article will approach the singularities that make personalized and highly specialized care essential in this field.
Recent findings
Drug desensitization nee...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research
Optimizing preoperative prophylaxis in patients with reported β-lactam allergy: a novel extension of antimicrobial stewardship
ConclusionsUsing a simple structured history and the principles of prospective audit and feedback, we were able to increase the use of cefazolin perioperative prophylaxis without any serious adverse events and in the absence of skin testing or diagnostic challenges.
Source: Journal of Antimicrobial Chemotherapy - June 10, 2017 Category: Microbiology Source Type: research
Mitomycin C allergy after passive and device-assisted hyperthermia for non-muscle invasive bladder cancer treatment: A retrospective cohort from a high-volume center
CONCLUSION: MMC allergy risk is increased with the use of device-assisted hyperthermia with an incidence of 2.4% for passive MMC and 6.9% for CHT. History of prior allergies does not seem to increase the risk of developing MMC allergy. In this series 38% of suspected cases were found to be pseudo-allergic reactions, highlighting the need to confirm the diagnosis before definitively stopping the treatment.PMID:35430137 | DOI:10.1016/j.urolonc.2022.02.018
Source: Urologic Oncology - April 17, 2022 Category: Urology & Nephrology Authors: Daniel Antonio Gonz ález-Padilla Jos é Daniel Subiela Alejandro Gonz ález-DÃaz Mario Hern ández-Arroyo Esther Garc Ãa-Rojo Julia Aumatell Javier Burgos Revilla Alfredo Rodr Ãguez-AntolÃn F élix Guerrero-Ramos Source Type: research
Optimizing Empiric Antibiotic Therapy in Patients with Severe β-lactam Allergy.
The objective of this study was to determine which alternate antibiotics or combinations provide adequate empiric therapy for patients with β-lactam allergy who develop gram-negative infections at our institution. We further sought to determine the effect of risk factors for drug resistance on empiric adequacy. A retrospective analysis was conducted of adult patients hospitalized from September 2009 to May 2010 who had a severe β-lactam allergy; a urine, blood, or respiratory culture positive for a gram-negative organism; and met pre-defined criteria for infection. Patient characteristics, culture and susceptibility data...
Source: Antimicrobial Agents and Chemotherapy - September 16, 2013 Category: Microbiology Authors: Koliscak LP, Johnson JW, Beardsley JR, Miller DP, Williamson JC, Luther VP, Ohl CA Tags: Antimicrob Agents Chemother Source Type: research
Is direct oral amoxicillin challenge a viable approach for ‘low-risk’ patients labelled with penicillin allergy?
AbstractSpurious penicillin allergy (PenA) is a major public health problem. Up to 10% of the population and 20% of inpatients are labelled with PenA, but only<5% –10% have a proven allergy following comprehensive investigations. PenA tests are labour intensive and require specialist input, which may not be readily available due to limited allergy services. Therefore, patients with PenA receive alternative antibiotics that are associated with higher rates o f iatrogenic infections, antimicrobial resistance and a longer hospital stay with consequent increased costs. Recent evidence suggests that a supervised ‘directâ...
Source: Journal of Antimicrobial Chemotherapy - June 5, 2019 Category: Microbiology Source Type: research
The long-term impact of beta-lactam antibiotic allergy testing - A matched case-control study.
This study supports the implementation of antibiotic allergy testing program (AAT) as a standard of care of antimicrobial stewardship (AMS) programs.
PMID: 32988819 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - September 27, 2020 Category: Microbiology Authors: Trubiano JA, Marhoon N, Vogrin S, Chua KYL, Holmes NE Tags: Antimicrob Agents Chemother Source Type: research
