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Total 1918 results found since Jan 2013.
The Low Risks and High Rewards of Penicillin Allergy Delabeling: An Algorithm to Expedite the Evaluation
A father brings his 2 sons, ages 11 and 13 years, to an allergy clinic for testing for amoxicillin allergy. They both received amoxicillin for upper respiratory infections as toddlers, and one of them developed diarrhea. Both were labeled as penicillin allergic, but the family says both they and the pediatrician have forgotten who actually had the reaction. Their charts both carry the label of penicillin allergy.
Source: The Journal of Pediatrics - June 24, 2019 Category: Pediatrics Authors: Cathleen Collins Tags: Grand Rounds Source Type: research
Diagnosis and Management of Food Allergy
Food allergy is an immune-mediated disease and must be differentiated from other adverse effects related to food that are non –immune mediated. Symptoms of immunoglobulin (Ig) E–mediated allergy can range from mild to severe, and life-threatening anaphylaxis may occur. Current recommended strategies for diagnosis include the use of skin prick tests, allergen-specific serum IgE, and/or oral food challenges. Management e ntails allergen avoidance and appropriate treatment of allergic reactions should accidental ingestions occur. Treatment approaches under investigation include immunotherapy as well as biologics and novel...
Source: Pediatric Clinics of North America - August 4, 2019 Category: Pediatrics Authors: Roxanne Carbonell Oriel, Julie Wang Source Type: research
Active free secretory component and secretory IgA in human milk: do maternal vaccination, allergy, infection, mode of delivery, nutrition and active lifestyle change their concentrations?
CONCLUSION: This study suggests that active free SC is more impacted by maternal factors than active SIgA in human milk.
IMPACT: Active free secretory component (free SC) is more impacted by maternal factors than active secretory IgA (SIgA) in human milk.Vaccination during pregnancy, allergy, nutrition, type of delivery and active lifestyle affect the secretion of free SC in human milk, but not SIgA secretion.Free SC in human milk is a critical constituent of secretory IgA (SIgA) for immune exclusion against pathogens and its active concentration in milk strongly varies between mothers, partially due to their specific...
Source: Pediatric Research - May 19, 2020 Category: Pediatrics Authors: Demers-Mathieu V, Mathijssen G, Dapra C, Do DM, Medo E Tags: Pediatr Res Source Type: research
As soon as possible in IgE-cow ’s milk allergy immunotherapy
Conclusion: Oral immunotherapy is a safe and effective treatment against allergy to cow ’s milk proteins in infants. Such treatment should be offered to the children’s families from the first moment of diagnosis.What is known:• Cow’s milk proteins are responsible for the earliest IgE-mediated allergic reactions in children.• Oral immunotherapy (OIT) is commonly used as cow’s milk allergy treatment and it is proposed at different ages.What is new:• OIT it is an effective and safe method with no severe reactions at early ages.• The number of reaching successful treatments is awesome so we believe that immunit...
Source: European Journal of Pediatrics - January 1, 2021 Category: Pediatrics Source Type: research
Lactose Intolerance in Pediatric Patients and Common Misunderstandings About Cow's Milk Allergy
Pediatr Ann. 2021 Apr;50(4):e178-e185. doi: 10.3928/19382359-20210312-01. Epub 2021 Apr 1.ABSTRACTLactose intolerance is a common gastrointestinal condition caused by the inability to digest and absorb dietary lactose. Primary lactose intolerance is the most common type of lactose intolerance. It is one of the most common forms of food intolerance and occurs when lactase activity is reduced in the brush border of the small bowel mucosa. People may be lactose intolerant to varying degrees, depending on the severity of these symptoms. When lactose is not digested, it is fermented by gut microbiota, leading to abdominal pain,...
Source: Pediatric Annals - May 27, 2021 Category: Pediatrics Authors: Margherita Di Costanzo Giacomo Biasucci Ylenia Maddalena Carmen Di Scala Carmen De Caro Antonio Calignano Roberto Berni Canani Source Type: research
Separating Fact from Fiction in the Diagnosis and Management of Food Allergy
E.A. is an employee of Public Health Agency of Canada (PHAC). The views expressed in this article are her own and not that of PHAC. M.G. is is a consultant for Aquestive; is a member of physician/medical advisory boards for DBV Technologies, Sanofi/Regeneron, Genentech, Nutricia, Novartis, Acquestive, Allergy Therapeutics, Pfizer, ALK-Abello, US World Meds, Allergenis, Aravax, and Prota; is a member of the scientific advisory council for the National Peanut Board; is an associate editor for the Annals of Allergy, Asthma, and Immunology, and is member of the Joint Taskforce on Allergy Practice Parameters.
Source: The Journal of Pediatrics - October 19, 2021 Category: Pediatrics Authors: Elissa M. Abrams, Matthew Greenhawt, Marcus Shaker, Waleed Alqurashi Tags: Commentary Source Type: research
Section on Allergy and Immunology
Founded in 1948, the Section on Allergy and Immunology is dedicated to ensure that children receive the highest quality of allergy and immunology care. To accomplish its mission, the Section provides a number of educational programs, training and research programs, and continually advocates for improved allergy and immunology care and services.
Source: PEDIATRICS - December 1, 2022 Category: Pediatrics Source Type: research
Bifidobacteria modulate immune response in pediatric patients with cow's milk protein allergy
CONCLUSIONS: The probiotic treatment resulted in a decrease of circulating naive and activated CD4+ T cells, as well as degranulating basophils. These data suggest that the Bifidobacteria could have a beneficial effect in the modulation of oral tolerance to CMP.TRIAL REGISTRATION: ISRCTN69069358. URL of registration: https://www.isrctn.com/ISRCTN69069358 .IMPACT: Probiotic treatment with Bifidobacteria induces a reduction of both naive and activated circulating CD4+ T cells in pediatric patients with cow's milk allergy (CMA). The probiotic supplementation induces a decreased basophil degranulation. The immunological tolera...
Source: Pediatric Research - March 24, 2023 Category: Pediatrics Authors: Caterina Strisciuglio Alessandra Vitale Francesco Perna Federica Garziano Pasquale Dolce Serena Vitale Teresa Micillo Franca Oglio Michele Miraglia Del Giudice Giuseppe Matarese Carmen Gianfrani Source Type: research
Delabelling penicillin allergy is not rocket science
Up to 10% of children are labelled as ‘penicillin allergic’,1 in most cases before they even start school.2 However, following comprehensive allergy assessment, around 95% of penicillin allergy labels are found to be incorrect.3 Why this discordance? In children, the label may be applied following emergence of a viral exanthem (in those where symptoms were viral triggered), or due to non-allergic adverse events to the antibiotic which may be in part dependent on viral-antibiotic interactions (for instance, Ebstein-Barr infection and amoxicillin). In addition, sensitisation to penicillins wanes over time, with a...
Source: Archives of Disease in Childhood - April 19, 2023 Category: Pediatrics Authors: Turner, P. Tags: Editorial Source Type: research
Preventing food allergy fatalities
We describe the data behind the good practice points to facilitate their adoption in routine practice without generating additional anxiety for what is a comparatively rare event. We also propose an information leaflet for patients and carers, developed with patients and endorsed by two major allergy charities, to facilitate dissemination of the recommendations in this review.
Source: Archives of Disease in Childhood - August 17, 2023 Category: Pediatrics Authors: Foong, R.-X., Patel, N. B., Turner, P., Roberts, G. C., Fox, A. T. Tags: Review Source Type: research
High vitamin D in pregnancy may increase food allergy risk in children
Study results published in Allergy suggest that supplementing pregnant women with vitamin D may increase their children’s risk for developing food allergy in infancy.
Source: MedWire News - Pediatrics - January 4, 2013 Category: Pediatrics Source Type: news
Pacifier Cleaning Practices and Risk of Allergy Development
Infants with a diverse gut microbial flora are less likely to develop eczema and allergy.
Parental sucking of their infant’s pacifier is associated with a reduced risk of allergy development and an altered oral flora in their child. Transfer of oral microbes from parent to infant via the pacifier might be used in primary prevention. (Read the full article)
Source: PEDIATRICS - May 31, 2013 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research
Misdiagnosed Food Allergy Resulting in Severe Malnutrition in an Infant
As food allergies become increasingly prevalent and testing methods to identify "food allergy" increase in number, the importance of careful diagnosis has become even more critical. Misdiagnosis of food allergy and inappropriate use of unproven testing modalities may lead to a harmful food-elimination diet. This case is an example of an infant who was placed on an overly restrictive elimination diet at the recommendation of her health care providers, resulting in kwashiorkor and acquired acrodermatitis enteropathica.
Source: PEDIATRICS - July 1, 2013 Category: Pediatrics Authors: Alvares, M., Kao, L., Mittal, V., Wuu, A., Clark, A., Bird, J. A. Tags: Case Report Source Type: research
