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Gut microbial modulation attenuates emphysema development by suppressing inflammation and apoptosis
Recent work has suggested a microbial dysbiosis association between the lung and gut in respiratory diseases. Here, we demonstrated that gut microbiome modulation attenuated emphysema development. To modulate the gut microbiome, fecal microbiota transplantation (FMT) and diet modification were adopted to mice exposed to smoking and poly I:C for emphysema model. We analyzed the severity of emphysema by mean linear intercept (MLI) and apoptosis by fluorescent TUNEL assay. Microbiome analysis was also performed in feces and fecal extracellular vesicles (EV). MLI was significantly increased with smoking exposure. FMT or high-f...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Lee, S. H., Jang, Y. O., Choi, J. J., Oh, Y.-M., Lee, S. W. Tags: Allergy and immunology Source Type: research

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in proge...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice
Conclusion In conclusion, the present study showed that the oral administration of L. plantarum KLDS1.0318 normalized the parameters altered by CTX-induced toxicities, strengthening intestinal health by regulating the Th1/Th2 balance, ameliorating the intestinal morphology and improving profiles of intestinal microbiota and metabolism. Therefore, our findings suggested that the administration of L. plantarum KLDS1.0318 could be of significant advantage in reducing intestinal immunity impairment caused by cyclophosphamide. Ethics Statement This study was carried out according to the Animal Care Review Committee, Northeas...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell
Conclusions hucMSC exosomes are well tolerated in animal models. This study provides evidence for the safety of intravenous infusion in future clinical therapy.
Source: Cytotherapy - February 5, 2016 Category: Cytology Source Type: research

Obesity and Diabetes: Is Your Gut in Control?
LISTEN HERE: By Drs. David Niesel and Norbert Herzog, Medical Discovery News Your body is like a forest, providing a home to microscopic flora and fauna. In fact, your body is home to up to 100 times more microbes than your own cells, which make up your microbiome. While we provide them residence, these microbes help us out by providing a first line of defense against disease trying to invade our bodies, even breaking down food during digestion and producing vitamins. Now, the microbes that live in the digestive tract are helping us understand diabetes better. According to the Human Microbiome Project sponsored by the Nati...
Source: Science - The Huffington Post - December 21, 2015 Category: Science Source Type: news

Weight loss, encephalopathy, urinary difficulties and numb feet in a nigerian man
We described the first case of the TTR Leu12Pro mutation in 1999. To date it has been only described in a total of 3 patients, all European. Here we describe the first report of the TTR Leu12Pro variant in an African patient.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: McColgan, P., Viegas, S., Gandhi, S., Sheikh, F., Pinney, J., Fontana, M., Rowczenio, D., Shah, S., Jaumuktane, Z., Holton, J., Schott, J., Werring, D., Hawkins, P., Reilly, M. Tags: Genetics, Immunology (including allergy), Epilepsy and seizures, Headache (including migraine), Pain (neurology), Sexual and gender disorders, Radiology, Surgical diagnostic tests, Radiology (diagnostics) Association of British Neurologists (ABN) joint Source Type: research