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Nutrition: Vitamins
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Total 289 results found since Jan 2013.
Vitamin D Receptor Regulates Autophagy to Inhibit Apoptosis and Promote Proliferation in Hepatocyte Injury
CONCLUSIONS: VDR mediates hepatocyte apoptosis and proliferation through autophagy.PMID:36908130 | DOI:10.1272/jnms.JNMS.2023_90-114
Source: Journal of Nippon Medical School - March 13, 2023 Category: Universities & Medical Training Authors: Mingming Fang Chen Zhong Source Type: research
Abstract 191: Transcriptional Regulation of Renin by Nuclear Receptors Co-regulated With Renin Poster Session I
Expression of the renin gene is required to maintain normal morphological and physiological identity of renal juxtaglomerular (JG) cells, yet the mechanisms regulating renin gene transcription remain elusive. We re-examined data from Brunskill et. al (JASN 22:2213, 2011), investigating genome-wide gene expression in JG and other renal cell types. Based on our previous data implicating nuclear receptors (RAR, RXR, VDR, PPARG, Nr2f2 and Nr2f6) in the regulation of mouse and human renin gene expression, we focused our analysis on the expression of genes encoding the 48 nuclear hormone receptors and their co-regulation with re...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Lu, K.-T., Weatherford, E. T., Ketsawatsomkron, P., Grobe, J. L., Sigmund, C. D. Tags: Poster Session I Source Type: research
Vitamin D and its receptor regulate lipopolysaccharide‐induced transforming growth factor‐β, angiotensinogen expression and podocytes apoptosis via the nuclear factor‐κB pathway
ConclusionsVitamin D and its receptor may be involved in the progression of diabetic nephropathy by regulating transforming growth factor‐β, angiotensinogen expression and apoptosis of podocytes. The processes are mediated via the signaling of nuclear factor ‐κB pathway.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - January 1, 2016 Category: Endocrinology Authors: Lijuan Xu, Pengyuan Zhang, Hongyu Guan, Zhimin Huang, Xiaoying He, Xuesi Wan, Haipeng Xiao, Yanbing Li Tags: Original Article Source Type: research
Leading RNA Interference Therapeutics Part 1: Silencing Hereditary Transthyretin Amyloidosis, with a Focus on Patisiran
AbstractIn 2018, patisiran was the first-ever RNA interference (RNAi)-based drug approved by the US Food and Drug Administration. Now pharmacology textbooks may include a new drug class that results in the effect first described by Fire and Mello 2 decades ago: post-transcriptional gene silencing by a small-interfering RNA (siRNA). Patients with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) present with mutations in the transthyretin (TTR) gene that lead to the formation of amyloid deposits in peripheral nerves and heart. The disease may also affect the eye and central nervous system. The formulatio...
Source: Molecular Diagnosis and Therapy - November 6, 2019 Category: Molecular Biology Source Type: research
Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts
In conclusion, Fam210a might enhance myoblast differentiation and proteolysis. Moreover, insulin and 1,25(OH)2D may induce myoblast differentiation and degradation by enhancing the expression of Fam210a.
Source: Calcified Tissue International - January 23, 2020 Category: Orthopaedics Source Type: research
Vitamin D and its receptor regulate lipopolysaccharide ‐induced transforming growth factor‐β, angiotensinogen expression and podocytes apoptosis through the nuclear factor‐κB pathway
ConclusionsVitamin D and its receptor might be involved in the progression of diabetic nephropathy by regulating transforming growth factor‐β, angiotensinogen expression and apoptosis of podocytes. The processes are mediated through the signaling of nuclear factor‐κB pathway.
Vitamin D and its receptor may be involved in the progression of diabetic nephropathy by regulating transforming growth factor‐β and angiotensinogen expression, and as well as the apoptosis of podocytes. The processes are mediated via the signaling of nuclear factor ‐κB pathway.
Source: Journal of Diabetes Investigation - March 31, 2016 Category: Endocrinology Authors: Lijuan Xu, Pengyuan Zhang, Hongyu Guan, Zhimin Huang, Xiaoying He, Xuesi Wan, Haipeng Xiao, Yanbing Li Tags: Original Article Source Type: research
Homocysteine induced oxidative stress in human umbilical vein endothelial cells via regulating methylation of SORBS1.
CONCLUSIONS: We indicated that Hcy induced oxidative stress in HUVECs via regulating methylation of SORBS1. We also found that Fc and B12 treatment attenuated the oxidative stress and inflammation induced by Hcy in HUVECs. The findings indicated that Fc and B12 might be effective agents for the treatment of Hcy induced AS.
PMID: 30402861 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 9, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Vitamin C Prevents Hydrocortisone-Induced Injury in HMEC-1 through Promoting Bestrophin-3 Expression.
CONCLUSIONS: VC can efficiently attenuate HC-induced HMEC-1 cell injury, which may be related to promote Best-3 expression.
PMID: 30672332 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - January 23, 2019 Category: Cancer & Oncology Authors: Wang X, Zhang G, Zhu C, Lin L, Zhao Z, Yu X, Liu G, Zhang H, Li Q, Dong W, Wang J Tags: Nutr Cancer Source Type: research
