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Total 71 results found since Jan 2013.

Inhibition of CDC25B With WG-391D Impedes the Tumorigenesis of Ovarian Cancer
Conclusions In conclusion, this study demonstrated that CDC25B was over-expressed in ovarian cancers. WG-391D efficiently inhibited ovarian cancer cell proliferation and migration, was associated with the induction of cell cycle arrest at G2/M phase and apoptosis, and inhibited the tumorigenesis of ovarian cancer in both SKOV3 cell and PDX BALB/c athymic nude mouse models. The anti-tumor activity of WG-391D involved down-regulation of CDC25B and subsequent inactivation of CDC2 and AKT. In conclusion, our data demonstrate that WG-391D has potential to be very valuable for the development of chemotherapeutic drugs for use i...
Source: Frontiers in Oncology - April 8, 2019 Category: Cancer & Oncology Source Type: research

A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression
Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulate...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Janssen Highlights Commitment to Advancing Transformative Innovations in Oncology with Scientific Updates from Deep, Diverse Pipeline and Portfolio at ASCO and EHA Virtual Scientific Programs
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 30 company-sponsored studies, including six oral presentations, will be featured during the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, June 4-8. Janssen presentations will include new data and updates for both approved and investigational therapeutics that are being studied for the treatment of various solid tumors and blood cancers. Immediately following ASCO, additional data will be featured during the European Hematology Association (EHA) Virtual Congress, June 9-17. A comp...
Source: Johnson and Johnson - June 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Therapeutic oxygen delivery by perfluorocarbon-based colloids
Adv Colloid Interface Sci. 2021 May 1;294:102407. doi: 10.1016/j.cis.2021.102407. Online ahead of print.ABSTRACTAfter the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed untoward effects to the product, the development of perfluorocarbon (PFC)-based O2 nanoemulsions ("blood substitutes") has come to a low. Yet, significant further demonstrations of PFC O2-delivery efficacy have continuously been reported, such as relief of hypoxia after myocardial infarction or stroke; protection of vital organs during surg...
Source: Advances in Colloid and Interface Science - June 13, 2021 Category: Chemistry Authors: Marie Pierre Krafft Jean G Riess Source Type: research

Biomaterial-Based Activation and Expansion of Tumor-Specific T Cells
Marjolein Schluck1,2, Roel Hammink1,2, Carl G. Figdor1,2,3, Martijn Verdoes1,3*† and Jorieke Weiden1,2,3*† 1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands 2Division of Immunotherapy, Oncode Institute, Radboud University Medical Center, Nijmegen, Netherlands 3Institute for Chemical Immunology, Nijmegen, Netherlands Traditional tumor vaccination approaches mostly focus on activating dendritic cells (DCs) by providing them with a source of tumor antigens and/or adjuvants, which in turn activate tumor-reactive T...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

GSH ‐Responsive Metal–Organic Framework for Intratumoral Release of NO and IDO Inhibitor to Enhance Antitumor Immunotherapy
A nanodrug (BMS-SNAP-MOF) is developed based on a glutathione-sensitive metal –organic framework to mediate effective immunotherapy against triple-negative breast cancer via combinational indoleamine 2,3-dioxygenase inhibition, and nitric oxide therapy. The nanodrug exhibits interesting tumor microenvironment responsiveness and magnetic resonance imaging ability, representi ng a potential widely applicable nanoplatform for tumor combination immunotherapy. AbstractImmunotherapy brings great benefits for tumor therapy in clinical treatments but encounters the severe challenge of low response rate mainly because of the immu...
Source: Small - February 26, 2022 Category: Nanotechnology Authors: Lihua Du, Haozhe He, Zecong Xiao, Hong Xiao, Yongcheng An, Huihai Zhong, Minzhao Lin, Xiaochun Meng, Shisong Han, Xintao Shuai Tags: Research Article Source Type: research

Immunotherapies catering to the unmet medical need of cold colorectal cancer
As a common malignant tumor of gastrointestinal tract, the incidence of colorectal cancer (CRC) has gradually increased in recent years. In western developed countries, it has even become the second largest malignant tumor next to lung cancer. Immunotherapy is a hot topic in the field of cancer therapy, including immune checkpoint blockade (ICB), adoptive cell therapy (ACT), cancer vaccines and cytokines, aiming to improve the ability of the immune system to recognize, target and eliminate cancer cells. However, cold CRC, which accounts for a high proportion of CRC, is not so reactive to it. The development of immunotherap...
Source: Frontiers in Immunology - October 5, 2022 Category: Allergy & Immunology Source Type: research

Detection and quantitative analysis of tumor-associated tertiary lymphoid structures
This study reviews the latest research progress on TLS detection and quantification, proposes new directions for TLS assessment, and addresses issues for the quantitative application of TLSs in the clinic.PMID:37701955 | PMC:PMC10500099 | DOI:10.1631/jzus.B2200605
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Man Yang Yurou Che Kezhen Li Zengyi Fang Simin Li Mei Wang Yiyao Zhang Zhu Xu Liping Luo Chuan Wu Xin Lai Weidong Wang Source Type: research

Discovery of IDO1 and DNA Dual Targeting Antitumor Agents
Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02529G, CommunicationKun Fang, Shanchao Wu, Guoqiang Dong, Ying Wu, Shuqiang Chen, Jianhe Liu, Wei Wang, Chunquan Sheng The development of small molecules for cancer immunotherapy is highly challenging and indoleamine 2,3-dioxygenase 1 (IDO1) represents a promising target. Inspired by the synergistic effects between IDO1 inhibitors and traditional... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - November 20, 2017 Category: Molecular Biology Authors: Kun Fang Source Type: research