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Nutrition: Iron
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Total 255 results found since Jan 2013.
Ferrostatin-1 Blunts Right Ventricular Hypertrophy and Dysfunction in Pulmonary Arterial Hypertension by Suppressing the HMOX1/GSH Signaling
AbstractFerroptosis plays a critical role in pulmonary arterial hypertension (PAH)-induced right ventricular (RV) dysfunction, but key genes remain largely unclear. We here identified HMOX1 as an essential ferroptosis-related differentially expressed gene in PAH by bioinformatic analysis using FerrDb, GSE119754, and GSE3675 datasets, respectively. Notably, there were marked increases in HMOX1 and iron levels in RV of monocrotaline-induced PAH rats with reduced TAPSE levels. More importantly, treatment with ferrostatin-1 effectively attenuated RV hypertrophy, remodeling, myocardial fibrosis, and dysfunction in PAH rats. In ...
Source: Journal of Cardiovascular Translational Research - August 21, 2023 Category: Cardiology Source Type: research
CREB-H is a stress-regulator of hepcidin gene expression during early postnatal development
In conclusion, CREB-H has a role in maintaining the homeostatic balance of iron traffic through hepcidin during the critical postnatal period and in response to iron challenge. KEY MESSAGES: CREB-H KO mice develop liver iron overload shortly after weaning that normalizes in adulthood. CHEB-H is involved in hepcidin gene response to oral iron in vivo. CREB-H loss hampers hepcidin promoter response to BMP6. CREB-H is a key stress-sensor controlling hepcidin gene transcription in physiologic and pathophysiologic states.PMID:37493829 | DOI:10.1007/s00109-023-02344-1
Source: Molecular Medicine - July 26, 2023 Category: Molecular Biology Authors: Chiara Vecchi Giuliana Montosi Cinzia Garuti Susanna Canali Manuela Sabelli Elisa Bergamini Andrea Ricci Elena Buzzetti Elena Corradini Antonello Pietrangelo Source Type: research
PICK1 modulates glycolysis and angiogenesis of hypoxic endothelial cells by regulating iron homeostasis
Mol Cell Biochem. 2023 Jun 27. doi: 10.1007/s11010-023-04795-z. Online ahead of print.ABSTRACTIron accumulation, which is controlled by transferrin receptor 1 (TfR1), modulates hypoxia-inducible factor-1α (HIF-1α) activation and angiogenesis of hypoxic endothelial cells. The study examined the role of protein interacting with C-kinase 1 (PICK1), a scaffold protein containing PDZ domain, in regulating glycolysis and angiogenesis of hypoxic vascular endothelial cells through its potential effect on TfR1, which features a supersecondary structure that interacts with the PDZ domain. Iron chelator deferoxamine and TfR1 siRNA ...
Source: Molecular and Cellular Biochemistry - June 27, 2023 Category: Biochemistry Authors: Yu Cao Hongbo Wang Shuyu Hu Qiaomin Xu Jun Ma Huile Wang Xiangqing Xiong Wantie Wang Liangrong Wang Source Type: research
Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPK α
CONCLUSIONS: Met shows effectiveness in relieving ferroptosis in cardiac I/R. In the future, Met may be an effective drug for relieving ferroptosis in cardiac I/R patients clinically.PMID:37288723 | DOI:10.1080/13880209.2023.2212700
Source: Pharmaceutical Biology - June 8, 2023 Category: Drugs & Pharmacology Authors: Zhenhua Wu Yunpeng Bai Yujuan Qi Chao Chang Yan Jiao Yaobang Bai Zhigang Guo Source Type: research
Superparamagnetic iron oxide nanoparticles target BxPC-3 cells and silence MUC4 for theranostics of pancreatic cancer
CONCLUSION: PEI-SPION-siRNA may be beneficial as a novel theranostic tool for PC.PMID:37236323 | DOI:10.1016/j.bbagen.2023.130383
Source: Biochimica et Biophysica Acta - May 26, 2023 Category: Biochemistry Authors: Yu Pu Helin Ke Changqiang Wu Shaodan Xu Yang Xiao Lina Han Guorong Lyv Shilin Li Source Type: research
Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway
In conclusion, we identified the new role of ferritinophagy and the GAS-STING pathway in Oroxylin A -mediated anti-hepatic fibrosis.PMID:37086511 | DOI:10.1016/j.biopha.2023.114653
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 22, 2023 Category: Drugs & Pharmacology Authors: Ying Sun Jingdan Weng Xiaolei Chen Shuyao Ma Yuxin Zhang Feng Zhang Zili Zhang Feixia Wang Jiangjuan Shao Shizhong Zheng Source Type: research
Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy
CONCLUSIONS: Sch B could ameliorate hepatic fibrosis through the promotion of activated HSCs senescence, which might be attributed to its induction of NCOA4-mediated ferritinophagy and subsequent iron overload.PMID:37010139 | DOI:10.1080/13880209.2023.2189908
Source: Pharmaceutical Biology - April 3, 2023 Category: Drugs & Pharmacology Authors: Mingyue Ma Na Wei Jieren Yang Tingting Ding Anping Song Lerong Chen Shuguo Zheng Huanhuan Jin Source Type: research
Iron-siRNA Nanohybrids for Enhanced Chemodynamic Therapy via Ferritin Heavy Chain Downregulation
Angew Chem Int Ed Engl. 2023 Mar 23:e202302255. doi: 10.1002/anie.202302255. Online ahead of print.ABSTRACTFerrous iron (Fe2+) has more potent hydroxyl radical (•OH)-generating ability than other Fenton-type metal ions, making Fe-based nanomaterials attractive for chemodynamic therapy (CDT). However, because Fe2+ can be converted by ferritin heavy chain (FHC) to nontoxic ferric form and then sequestered in ferritin, therapeutic outcomes of Fe-mediated CDT agents are still far from satisfactory. Here we report the synthesis of siRNA-embedded Fe0 nanoparticles (Fe0-siRNA NPs) for self-reinforcing CDT via FHC downregulation...
Source: Angewandte Chemie - March 23, 2023 Category: Chemistry Authors: Jun Wang Hongye Ding Yang Zhu Yina Liu Meili Yu Huilan Cai Rujiang Ao Hongwei Huang Peng Gong Yaxin Liao Zhaolin Chen Lisen Lin Xiaoyuan Chen Huanghao Yang Source Type: research
