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Nutrition: Iron

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Total 255 results found since Jan 2013.

Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells
CONCLUSION: Taken together, our findings indicate that temozolomide may suppress cell growth partly by inducing ferroptosis by targeting DMT1 expression in glioblastoma cells.PMID:34427071 | PMC:PMC8382730 | DOI:10.3349/ymj.2021.62.9.843
Source: Yonsei Medical Journal - August 24, 2021 Category: Universities & Medical Training Authors: Qingxin Song Shanxin Peng Zhiqing Sun Xueyuan Heng Xiaosong Zhu Source Type: research

Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes
Biomed Pharmacother. 2021 Nov;143:112223. doi: 10.1016/j.biopha.2021.112223. Epub 2021 Sep 25.ABSTRACTFerroptosis is a recently recognized process of cell death characterized by accumulation of iron-dependent lipid peroxides. Herein, we demonstrate that peroxisome proliferator-activated receptor δ (PPARδ) inhibits ferroptosis of mouse embryonic fibroblasts (MEFs) derived from cysteine/glutamate transporter (xCT)-knockout mice. Activation of PPARδ by the specific ligand GW501516 led to a dose-dependent decrease in ferroptotic cell death triggered by xCT deficiency, along with decreased levels of intracellular iron accumu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 15, 2021 Category: Drugs & Pharmacology Authors: Jung Seok Hwang Eunsu Kim Hyuk Gyoon Lee Won Jin Lee Jun Pil Won Jinwoo Hur Junichi Fujii Han Geuk Seo Source Type: research

Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis
CONCLUSION: This research suggested that H2S alleviated PM-induced emphysema and airway inflammation via restoring redox balance and inhibiting ferroptosis through regulating Nrf2-PPAR-ferritinophagy signaling pathway.PMID:35490984 | DOI:10.1016/j.freeradbiomed.2022.04.014
Source: Free Radical Biology and Medicine - May 1, 2022 Category: Biology Authors: Ying Wang Sha Liao Zihan Pan Simin Jiang Jing Fan Siwang Yu Lixiang Xue Jianling Yang Shaohua Ma Tong Liu Jing Zhang Yahong Chen Source Type: research

5 ‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis
Oncol Rep. 2022 Oct;48(4):186. doi: 10.3892/or.2022.8401. Epub 2022 Sep 9.ABSTRACTIron is an essential nutrient that facilitates cell proliferation and growth, and it can contribute to tumor growth. Although iron chelators have shown great potential in preclinical cancer models, they can cause adverse side‑effects. The aim of the present study was to determine whether treatment with 5‑aminolevurinic acid (5‑ALA) has antitumor effects in bladder cancer, by reduction of mitochondrial iron without using an iron chelator, through activation of heme synthesis. T24 and MGH‑U3 cells were treated with 5‑ALA. Ferrochelata...
Source: Oncology Reports - September 9, 2022 Category: Cancer & Oncology Authors: Yasushi Nakai Yoshihiro Tatsumi Shunta Hori Yosuke Morizawa Kota Iida Kenta Onishi Makito Miyake Yuki Oda Takuya Owari Tomomi Fujii Sayuri Onishi Nobumichi Tanaka Kiyohide Fujimoto Source Type: research

Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus Calmette-Guerin infection
Macrophages are the host cells and the frontline defense against Mycobacterium tuberculosis (Mtb) infection, and the form of death of infected macrophages plays a pivotal role in the outcome of Mtb infections. Ferroptosis, a programmed necrotic cell death induced by overwhelming lipid peroxidation, was confirmed as one of the mechanisms of Mtb spread following infection and the pathogenesis of tuberculosis (TB). However, the mechanism underlying the macrophage ferroptosis induced by Mtb infection has not yet been fully understood. In the present study, transcriptome analysis revealed the upregulation of heme oxygenase-1 (H...
Source: Frontiers in cellular and infection microbiology - September 23, 2022 Category: Microbiology Source Type: research

Hydrogen sulfide alleviates beryllium sulfate ‐induced ferroptosis and ferritinophagy in 16HBE cells
This study aimed to investigate the effect of H2S on BeSO4-induced ferroptosis and ferritinophagy in 16HBE cells, and the underlying mechanism. In this study, BeSO4-induced 16HBE cell injury model was established based on cellular level, and pretreated with Deferoxamine (DFO, a ferroptosis inhibitor), Sodium hydrosulfide (NaHS, a H2S donor), or NCOA4 siRNA; subsequently, performed to detect the levels of lipid peroxidation and Fe2+, and the biomarkers of ferroptosis and ferritinophagy. More importantly, our research found that DFO, NaHS or NCOA4 siRNA alleviated BeSO4-induced ferroptosis and ferritinophagy by decreasing th...
Source: Journal of Applied Toxicology - February 27, 2023 Category: Toxicology Authors: Xiuli Liu, Guilan Li, Shaoxiong Chen, Huiyun Jin, Xiaodong Liu, Linfang Zhang, Zhaohui Zhang Tags: RESEARCH ARTICLE Source Type: research

Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin
We examined the role of DMT1 inhibition or salinomycin in promoting ferroptosis by lysosomal iron targeting in HNC cells. RNA interference was performed by transfection of siRNA targeting DMT1 or scrambled control siRNA in HNC cell lines. Cell death and viability, lipid peroxidation, iron contents, and molecular expression were compared between the DMT1 silencing or salinomycin group and the control. DMT1 silencing markedly accelerated cell death induced by the ferroptosis inducers. DMT1 silencing marked increases in the labile iron pool, intracellular ferrous and total iron contents, and lipid peroxidation. DMT1 silencing...
Source: Human Cell - March 8, 2023 Category: Cytology Source Type: research

Regulation of Hippo/YAP signaling pathway ameliorates cochlear hair cell injury by regulating ferroptosis
In conclusion, YAP1 ameliorated cochlear hair cell injury by upregulating FTL and TFRC to suppress ferroptosis.PMID:36889225 | DOI:10.1016/j.tice.2023.102051
Source: Tissue and Cell - March 8, 2023 Category: Cytology Authors: Xiaorong Niu Peng Han Junsong Liu Zichen Chen Xiaoyan Ma Ting Zhang Baiya Li Xudong Ma Source Type: research