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Nutrition: Iron

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Total 255 results found since Jan 2013.

Hemin protects against Zika virus infection by disrupting virus-endosome fusion
This study elaborated that hemin could play anti-ZIKV activity by disrupting the virus-endosome fusion process and shed new light on developing novel agents against ZIKV infection.PMID:35643150 | DOI:10.1016/j.antiviral.2022.105347
Source: Antiviral Research - June 1, 2022 Category: Virology Authors: Meng-Meng Xu Bing Wu Guan-Gen Huang Chun-Lan Feng Xiao-Han Wang Hao-Yu Wang Yan-Wei Wu Wei Tang Source Type: research

Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis
In conclusion, irisin could ameliorate inflammatory microenvironment in SAE by suppressing hippocampus ferroptosis via the Nrf2/GPX4 signaling pathway.PMID:35660523 | DOI:10.1016/j.freeradbiomed.2022.05.023
Source: Free Radical Biology and Medicine - June 6, 2022 Category: Biology Authors: Jin Wang Qian Zhu Yun Wang Jun Peng Liang Shao Xinyi Li Source Type: research

Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation
Eur J Pharmacol. 2022 Jun 6:175085. doi: 10.1016/j.ejphar.2022.175085. Online ahead of print.ABSTRACTBrowning, a white to brown-like (beige) adipocyte conversion, offers a promising therapeutic strategy for the treatment of human obesity. In the present study, the effects of sodium salicylate, a nonsteroidal anti-inflammatory drug, on adipocyte browning were investigated. We found sodium salicylate altered the macrophage phenotype to M2 in RAW264.7 cells, mediated by up-regulation of heme oxygenase-1 (HO-1), and sodium salicylate-treated conditioned medium from macrophages (Sal-M2 CM) induced browning of fully differentiat...
Source: European Journal of Pharmacology - June 9, 2022 Category: Drugs & Pharmacology Authors: Hye-Eun Choi Eun Jeong Jeon Dong Young Kim Mi Jin Choi Hana Yu Jea Il Kim Hyae Gyeong Cheon Source Type: research

Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance
AbstractCancer has presented to be the most challenging disease, contributing to one in six mortalities worldwide. The current treatment regimen involves multiple rounds of chemotherapy administration, alone or in combination. The treatment has adverse effects including cardiomyopathy, hepatotoxicity, and nephrotoxicity. In addition, the development of resistance to chemo has been attributed to cancer relapse and low patient overall survivability. Multiple drug resistance development may be through numerous factors such as up-regulation of drug transporters, drug inactivation, alteration of drug targets and drug degradatio...
Source: Apoptosis - June 18, 2022 Category: Molecular Biology Source Type: research

Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway
In this study, we attempted to investigate a novel mechanism by which WG mitigates liver fibrosis by inducing ferroptosis in hepatic stellate cells (HSCs). A CCl4 -induced mouse liver fibrosis model and a rat HSC line were employed for in vivo and in vitro experiments, both treated with WG. Firstly, the levels of the fibrotic markers α-smooth muscle actin (α-SMA) and α1(I)collagen (COL1α1) were effectively decreased by WG in CCl4 -induced mice and HSC-T6 cells. Additionally, mitochondrial condensation and mitochondrial ridge breakage were observed in WG-treated HSC-T6 cells. Furthermore, ferroptotic events including de...
Source: Cell Research - July 11, 2022 Category: Cytology Authors: Guofang Liu Can Wei Siyu Yuan Zhe Zhang Jiahao Li Lijun Zhang Guokai Wang Ling Fang Source Type: research

Case Report: Lack of Response to Givosiran in a Case of ALAD Porphyria
Discussion: No adverse effects of givosiran on the liver were observed in this patient with cirrhosis during 6 months of treatment with givosiran. The patient has continued to have recurrent attacks, with transient decreases in ALA levels only as related to treatment of his attacks with hemin. Our experience limited to one patient with ADP suggests that givosiran may not be effective in this type of acute porphyria. Since ADP may have an erythropoietic component, treatment with hydroxyurea, which was beneficial in one previous case, is planned.
Source: Frontiers in Genetics - August 4, 2022 Category: Genetics & Stem Cells Source Type: research

Zinc induces hephaestin expression via a PI3K-CDX2 dependent mechanism to regulate iron transport in intestinal Caco-2 cells
Biochem Biophys Res Commun. 2022 Jul 30;626:1-7. doi: 10.1016/j.bbrc.2022.07.053. Online ahead of print.ABSTRACTZinc stimulates intestinal iron absorption via induction of divalent metal ion transporter (DMT1) and hephaestin (HEPH). While the increase in DMT1 is mediated via a PI3K/IPR2 axis, the mechanisms of Zn-induced HEPH expression downstream of PI3K remain elusive. In the current study we probed the role of Caudal-related homeobox transcription factor-2 (CDX2) on Zn-induced HEPH expression. Zn treatment of Caco-2 cells increased CDX2 phosphorylation and HEPH protein and mRNA expression. siRNA-silencing of CDX2 inhibi...
Source: Biochemical and Biophysical Research communications - August 13, 2022 Category: Biochemistry Authors: Hanuma Naik Ramavath Purna Chandra Mashurabad Puneeta Singh Yaduvanshi Shobi Veleri Paul A Sharp Raghu Pullakhandam Source Type: research

Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3 β/Nrf2 axis
In conclusion, Dex protects hearts against MIRI-induced ferroptosis via activation of Nrf2 through AMPK/GSK-3β signaling pathway.PMID:35988428 | DOI:10.1016/j.biopha.2022.113572
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 21, 2022 Category: Drugs & Pharmacology Authors: Zhuoran Wang Mengran Yao Leyu Jiang Lingyan Wang Yuqiao Yang Quan Wang Xi Qian Yu Zhao Jinqiao Qian Source Type: research

Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol
This study showed that DOX decreased cell viability, increased iron accumulation and lipid peroxidation in H9c2 cells; however, these effects were reversed by RSV and ferroptosis inhibitor ferrostatin-1 (Fer-1) pre-treatment. Additionally, RSV significantly increased the cell viability of H9c2 cells treated with ferroptosis inducers Erastin (Era) and RSL3. Mechanistically, RSV inhibited mitochondrial reactive oxygen species (mtROS) overproduction and upregulated the p62-NRF2/HO-1 pathway. RSV-induced NRF2 activation was partially dependent on p62, and the selective inhibition of p62 (using p62-siRNA interference) or NRF2 (...
Source: The American Journal of Chinese Medicine - October 30, 2022 Category: Complementary Medicine Authors: Wei Yu Chunjuan Chen Chenxi Xu De Xie Qiang Wang Weidong Liu Hairong Zhao Furong He Bingyang Chen Yuemei Xi Yunbo Yan Linqian Yu Jidong Cheng Source Type: research

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