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Treatment of eosinophilic esophagitis with diets: an update.
Authors: Lucendo AJ, Molina-Infante J Abstract Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease triggered and maintained predominantly by food antigens. It represents a unique form of non-IgE mediated food allergy, largely dependent upon delayed, cell-mediated hypersensitivity. First-line therapies for EoE consist on drugs with anti-inflammatory effect (mainly including topic steroids and proton pump inhibitors) and dietary therapy. An elimination diet that avoids the consumption of food triggers currently remains the only therapy targeting the cause of EoE. Currently, available food alle...
Source: Minerva Gastroenterologica e Dietologica - November 27, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Diagnostic challenges of celiac disease in a young child: A case report and a review of the literature
We present the case of a 1-year-old male child, with a history of idiopathic pericardial effusion, admitted in our clinic for severe abdominal bloating, irritability, loss of appetite and intermittent diarrheic stools. The clinical findings were: influenced general status, irritability, distended abdomen, and diffuse abdominal tenderness. Diagnoses: The initial laboratory tests revealed anemia, leukocytosis, increased inflammatory biomarkers, high levels of transaminases, and hypoalbuminemia. The stool culture identified an enterocolitis with enteropathogenic Escherichia coli (E. coli). Interventions: We initiated an...
Source: Medicine - June 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Treatment of eosinophilic esophagitis in the pediatric patient: an evidence-based approach
Conclusion: Applying evidence-based therapies and a practical management algorithm provide an effective control of EoE.What is Known:•Eosinophilic esophagitis (EoE) now constitutes the main cause of dysphagia and food impaction in children, adolescents, and young adults.•Its chronic course and frequent progression to subepithelial fibrosis leading to strictures and narrow-caliber esophagus indicate the need for treatment.What is New:•Therapeutic goals in children with EoE include resolution of esophageal symptoms, to cure esophageal inflammation (mucosal healing) and restore a proper esophageal caliber in case of fib...
Source: European Journal of Pediatrics - March 17, 2018 Category: Pediatrics Source Type: research

Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: The 2-4-6 study
Numerous dietary restrictions and endoscopies limit the implementation of empiric elimination diets in patients with eosinophilic esophagitis (EoE). Milk and wheat/gluten are the most common food triggers.
Source: Journal of Allergy and Clinical Immunology - October 23, 2017 Category: Allergy & Immunology Authors: Javier Molina-Infante, Ángel Arias, Javier Alcedo, Ruth Garcia-Romero, Sergio Casabona-Frances, Alicia Prieto-Garcia, Ines Modolell, Pedro L. Gonzalez-Cordero, Isabel Perez-Martinez, Jose Luis Martin-Lorente, Carlos Guarner-Argente, Maria L. Masiques, Vi Tags: Food allergy and gastrointestinal disease Source Type: research

Celiac disease: 5 things parents need to know
Dr. Dascha Weir, associate director, Boston Children’s Celiac Disease Program It may be difficult for parents to hear that their child has a chronic illness. When the diagnosis is celiac disease (CD), an autoimmune disorder caused by an intolerance to gluten, there is good news. CD is treatable by changes in diet. How it works: When food enters the stomach, it’s broken down into tiny digestible particles, which then travel through the small intestine. The small intestine is lined with villi — tiny finger-like projections that absorb nutrients from the food passing through. In celiac disease, gluten, which is a pro...
Source: Thrive, Children's Hospital Boston - September 28, 2016 Category: Pediatrics Authors: Maureen McCarthy Tags: Diseases & Conditions celiac disease Dr. Dascha Weir gluten intolerance Source Type: news

Fewer People Are Sensitive To Gluten Than Commonly Believed
By Julie Upton for U.S. News It seems as if everyone is going to great lengths to avoid gluten, a protein found in wheat, barley, rye and many processed foods. Are there real health benefits associated with going gluten-free, or is it just another passing fad? A recently published study in the journal Digestion found that 86 percent of individuals who believed they were gluten sensitive could tolerate it. Individuals with celiac disease, a hereditary autoimmune condition that affects about 3 million Americans, or roughly 1 percent of the population, must avoid gluten. Those with extremely rare wheat allergies must also r...
Source: Healthy Living - The Huffington Post - June 21, 2015 Category: Consumer Health News Source Type: news

Gliadin Does Not Induce Mucosal Inflammation or Basophil Activation in Patients With Nonceliac Gluten Sensitivity
Conclusions: Unlike the duodenal mucosa from patients with celiac disease, upon incubation with gliadin, mucosa from patients with NCGS does not express markers of inflammation, and their basophils are not activated by gliadin. The in vitro gliadin challenge therefore should not be used to diagnose NCGS.
Source: Clinical Gastroenterology and Hepatology - May 1, 2013 Category: Gastroenterology Authors: Cristina Bucci, Fabiana Zingone, Ilaria Russo, Ivonne Morra, Raffaella Tortora, Norberto Pogna, Giulia Scalia, Paola Iovino, Carolina Ciacci Tags: Alimentary Tract Source Type: research