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Total 51 results found since Jan 2013.
Promotion of ABCG2 gene expression by neolignans from Piper longum L
Biosci Biotechnol Biochem. 2023 Sep 14:zbad132. doi: 10.1093/bbb/zbad132. Online ahead of print.ABSTRACTWe focused on Piper longum L., an herbal drug produced in Myanmar, which has a renoprotective effect. Thus, we attempted to isolate and identify compounds that enhance the expression of the ABCG2 gene from the aerial parts of the plant except for the fruit. Among the various P. longum extracts, we isolated and identified the components. Using Caco-2 cells, the hABCG2 mRNA expression-enhancing effects of the isolated compounds were compared with the positive reference compound (3-methylcholanthrene: 3MC) using real-time P...
Source: Bioscience, Biotechnology, and Biochemistry - September 14, 2023 Category: Biochemistry Authors: Atsuyoshi Nishina Motohiko Ukiya Kazuki Motegi Risa Kiryu Daisuke Sato Mitsuru Sada Yuki Hori Hideo Satsu Kazuhiro Uemura Mamoru Koketsu Masayuki Ninomiya Lwin Mon Mon Myint Hirokazu Kimura Source Type: research
Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway
In conclusion, apigenin protects cardiomyocyte function from oxidative stress-induced myocardial injury by modulating SIRT1 signaling pathway, which provides a new potential therapeutic natural compound for the clinical treatment of cardiovascular diseases.PMID:36781043 | DOI:10.1016/j.ejphar.2023.175584
Source: European Journal of Pharmacology - February 13, 2023 Category: Drugs & Pharmacology Authors: Kun Xu Yao Yang Ming Lan Jiannan Wang Bing Liu Mingjing Yan Hua Wang Wenlin Li Shenghui Sun Kaiyi Zhu Xiyue Zhang Mingyan Hei Xiuqing Huang Lin Dou Weiqing Tang Qing He Jian Li Tao Shen Source Type: research
Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer
Clinically, activated EGFR mutation associated chemo-drugs resistance has severely threaten NSCLC patients. Nanoparticle based small interfering RNA (siRNA) therapy representing another promising alternative b...
Source: Journal of Nanobiotechnology - February 5, 2023 Category: Nanotechnology Authors: Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen and Peng Cao Tags: Research Source Type: research
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway
CONCLUSIONS: These results indicate that cornin improved neurological recovery after cerebral ischemia injury by preventing astrocytes autophagy induced by CI/R via the PI3K/Akt/mTOR signaling pathway.PMID:36280856 | DOI:10.1186/s40360-022-00620-3
Source: BMC Pharmacology and Toxicology - October 25, 2022 Category: Drugs & Pharmacology Authors: Tianchi Lan Yangyang Xu Shucui Li Ning Li Shuping Zhang Haibo Zhu Source Type: research
BioClay < sup > TM < /sup > prolongs RNA interference-mediated crop protection against Botrytis cinerea
This article is protected by copyright. All rights reserved.PMID:36040241 | DOI:10.1111/jipb.13353
Source: Journal of Integrative Plant Biology - August 30, 2022 Category: Biology Authors: Jonatan Ni ño-Sánchez Prabhakaran Thanjavur Sambasivam Anne Sawyer Rachael Hamby Angela Chen Elizabeth Czislowski Peng Li Narelle Manzie Donald M Gardiner Rebecca Ford Zhi Ping Xu Neena Mitter Hailing Jin Source Type: research
Complete genome analysis of a novel iflavirus from the spotted lanternfly Lycorma delicatula
AbstractThe spotted lanternfly (Lycorma delicatula) is an invasive pest that causes serious economic losses in fruit and wood production. Here, we identified a novel iflavirus named"Lycorma delicatula iflavirus 1" (LDIV1), in a spotted lanternfly. The full genome sequence of LDIV1 is 10,222 nt in length and encodes a polyprotein containing a picornavirus capsid-protein-domain-like domain, a cricket paralysis virus capsid superfamily domain, an RNA helicase domain, a peptidase C3 superfamily domain, and an RNA-dependent RNA polymerase (RdRp) domain. LDIV1 replicates in the host insect and activates small interferi...
Source: Archives of Virology - June 25, 2022 Category: Virology Source Type: research
Lucidone inhibits autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt signaling pathway in pancreatic cancer cells
Phytother Res. 2022 Feb 28. doi: 10.1002/ptr.7385. Online ahead of print.ABSTRACTGemcitabine (GEM) drug resistance remains a difficult challenge in pancreatic ductal adenocarcinoma (PDAC) treatment. Therefore, identifying a safe and effective treatment strategy for PDAC is urgent. Lucidone is a natural compound extracted from the fruits of Lindera erythrocarpa Makino. However, the role of lucidone in PDAC inhibition remains unclear. In addition, high-mobility group box 1 (HMGB1) and receptor for advanced glycation end products (RAGE) are involved in multidrug resistance protein 1 (MDR1) regulation and GEM resistance. Thus,...
Source: Cell Research - February 28, 2022 Category: Cytology Authors: Sheng-Yi Chen Yi-Hao Hsu Sheng-Yang Wang Ying-Yin Chen Cheng-Jie Hong Gow-Chin Yen Source Type: research
Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis
CONCLUSION: In conclusion, fisetin effectively protected against LPS-induced oxidative stress and inflammatory responses which may be closely correlated to inhibition of TLR4-mediated ROS/NF-κB and activation of the Nrf2/HO-1 pathway.PMID:34262322 | PMC:PMC8275103 | DOI:10.2147/JIR.S314130
Source: Cell Research - July 15, 2021 Category: Cytology Authors: Kangfeng Jiang Jing Yang Guanhong Xue Ailing Dai Haichong Wu Source Type: research
Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NADFormula: see text-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research
