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Infectious Disease: Tuberculosis

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Total 482 results found since Jan 2013.

Reduced Phagocytic Capacity of Blood Monocyte/Macrophages in Tuberculosis Patients Is Further Reduced by Smoking.
Abstract Tuberculosis (TB) and tobacco use are two major alarming global health issues posing immense threats to human populations. Mycobacterium tuberculosis (MTB) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as CXCL-8, Il-12 and TNF-α which in turn induces the immune system network. However no information is available on other activity of cells by MTB and smoking. In the current study we aimed to investigate the serum levels TNF-a, CXCL-8 and phagocytosis capacity in tuberculosis patients with and without smoking. 103 subjects entered th...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 31, 2016 Category: Allergy & Immunology Authors: Aryanpur M, Mortaz E, Masjedi MR, Tabarsi P, Garssen J, Adcock IM, Mozafarian A, Sharifi H Tags: Iran J Allergy Asthma Immunol Source Type: research

Association of Promoter Polymorphisms of Interleukin-10 and Interferon-Gamma Genes with Tuberculosis in Azeri Population of Iran.
In this study, we investigated a possible association between interleukin-10 (IL-10) -1082A⁄G (rs1800896) and interferon (IFN)-gamma +874T/A (rs2430561) promoter polymorphisms and tuberculosis (TB) in the Azeri population of Iran. IL-10 -1082G/A and IFN-gamma +874T/A single nucleotide polymorphisms (SNPs) were genotyped by amplification refractory mutation system (ARMS)-PCR in 200 healthy controls and 124 tuberculosis patients. IL-10 -1082 A allele was more frequent in the control group than in the patient group (p=0.001, odds ratio [OR]=2.183). On the other hand, the AA genotype was significantly more frequent in the co...
Source: Iranian Journal of Allergy, Asthma and Immunology - May 31, 2016 Category: Allergy & Immunology Authors: Asgharzadeh M, Ghorghanlu S, Rashedi J, Mahdavi Poor B, Khaki-Khatibi F, Moaddab SR, Samadi-Kafil H, Pourostadi M Tags: Iran J Allergy Asthma Immunol Source Type: research

A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test.
Authors: Kim J, Park S, Jung CM, Oh CW, Kwon JW Abstract Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. In the present case, we performed LTT and a patch test, and successfully proved CS as the offending drug in this patient, who had been treated with multiple anti-Tb drugs. These observations suggest that CS should be considered a possible cause of LDE and that LTT can be an option for t...
Source: Allergy, Asthma and Immunology Research - March 16, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Association between atopic dermatitis and serious cutaneous, multiorgan and systemic infections in US adults.
CONCLUSION: Adults with AD had increased cutaneous, respiratory, multiorgan, and systemic infections, which were associated with a considerable cost burden. PMID: 29273131 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - December 25, 2017 Category: Allergy & Immunology Authors: Narla S, Silverberg JI Tags: Ann Allergy Asthma Immunol Source Type: research

What Immunological Defects Predispose to Non-tuberculosis Mycobacterial Infections?
Abstract Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil.  NTM cause a variety of diseases in humans that mainly affect the lung. A predisposition to pulmonary NTM is evident in patients with parenchymal structural diseases including bronchiectasis, emphysema, tuberculosis (TB), cystic fibrosis (CF), rheumatologic lung diseases and other chronic diseases with pulmonary manifestations. Lung infections are not the only consequences of being infected by NTM as they can also infect skin and soft tissue and may als...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2018 Category: Allergy & Immunology Authors: Mortaz E, Moloudizargari M, Varahram M, Movassaghi M, Garssen J, Kazempour Dizagie M, Mirsaeidi M, Adcock IM Tags: Iran J Allergy Asthma Immunol Source Type: research

miR-1224 Expression Is Increased in Human Macrophages after Infection with Bacillus Calmette-Gu érin (BCG).
This study highlighted the potential roles of miRNAs in host responses upon mycobacterium infection. PMID: 29908542 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2018 Category: Allergy & Immunology Authors: Alipoor SD, Mortaz E, Tabarsi P, Marjani M, Varahram M, Folkerts G, Garssen J, Adcock IM Tags: Iran J Allergy Asthma Immunol Source Type: research

Allergic bronchopulmonary aspergillosis complicating Swyer-James-Macleod's syndrome: case report and review of literature.
Authors: Sehgal IS, Dhooria S, Behera D, Agarwal R Abstract Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that results from immune responses mounted against antigens of Aspergillus fumigatus, resulting in non-specific respiratory symptoms and structural lung damage. Classically defined in individuals suffering from bronchial asthma and cystic fibrosis, ABPA has recently been described in other lung diseases including COPD, pulmonary tuberculosis, idiopathic bronchiectasis and others. Herein, we report the first case of ABPA complicating Swyer-James-Macleod's syndrome that was successfully t...
Source: European Annals of Allergy and Clinical Immunology - September 15, 2018 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Prevalence and Clinical Features of Drug Reactions With Eosinophilia and Systemic Symptoms Syndrome Caused by Antituberculosis Drugs: A Retrospective Cohort Study.
CONCLUSIONS: This study confirmed the prevalence of DRESS syndrome in a cohort of adult patients with tuberculosis. PMID: 30479080 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 29, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein.
Abstract Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system.MS creates a wide range of symptoms with lifelong debilitating consequences. The hallmark of the disease is the inflammation of the nervous system, which can lead to damage to the nerve tissue and loss of function of the neurons. IL-17 has a prominent role in the beginning of inflammatory reactions. Here, we analyzed a mouse model developed using anti-myelin antibodies. This mouse model mimics many symptoms of MS in humans. C57BL/6 mice were randomly divided into five groups. Mice were immunized subcutaneously with 50...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 7, 2019 Category: Allergy & Immunology Authors: Ghorbani MM, Farazmandfar T, Nasirikenari M, Abediankenari S, Meamarian A, Shahbazi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Primary immunodeficiency disorders in children with Non-Cystic Fibrosis Bronchiectasis.
Conclusions.PID accounted for about 40% of NCFB. Early diagnosis/appropriate treatment have impact on clinical course of a PID patient. Thus, follow-up in also immunology clinics should be a routine for patients who experience pneumonia in the first year of their lives and those with NCFB. Most patients with NCFB (84.28%) had their first pulmonary infection within the first year of their lives. PMID: 32372587 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - May 8, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Severe Cutaneous Adverse Reactions to Anti-tuberculosis Drugs in Korean Patients.
CONCLUSIONS: DRESS was more common among the ATD-related SCAR cases. Although treatment with most ATDs carries the risk of SCAR development, the use of rifampin was most frequently involved in the occurrence of SCARs. Multiple hypersensitivity was frequently observed in ATD-related SCARs. PMID: 33474859 [PubMed]
Source: Allergy, Asthma and Immunology Research - January 23, 2021 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

7th drug hypersensitivity meeting: part one
Table of contentsOral AbstractsO1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TENDaniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir PirmohamedO2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel YerlyO3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivityRebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, Davi...
Source: Clinical and Translational Allergy - August 24, 2016 Category: Allergy & Immunology Source Type: research

Transfer of peanut allergy from donor to recipient after liver transplant.
Authors: Aggarwal A, Balogun R, Carr TF, Desai AP, Jie T, Pan JJ Abstract 31 years old female with a history of contact dermatitis, eczema, allergic rhinitis, pernicious anemia, alopecia areata and latent tuberculosis was treated concurrently with methotrexate along with isoniazid and pyridoxine. Five months into the therapy she developed acute onset jaundice progressing into fulminant liver failure with altered mentation and worsening liver function tests. Extensive workup including serological and histopathological evaluation revealed drug-induced liver injury as the etiology of her liver failure and she underwen...
Source: Annals of Hepatology - May 1, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Developing aerosol vaccines for Mycobacterium tuberculosis: Workshop proceedings: April 9, 2014, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Abstract On April 9, 2014, Aeras and the National Institute of Allergy and Infectious Diseases convened a workshop entitled "Developing Aerosol Vaccines for Mycobacterium tuberculosis" in Bethesda, MD. The purpose of the meeting was to explore the potential for developing aerosol vaccines capable of preventing infection with M. tuberculosis (Mtb), preventing the development of active tuberculosis (TB) among those latently infected with Mtb, or as immunotherapy for persons with active TB. The workshop was organized around four key questions relevant to developing and assessing aerosol TB vaccines: (1) What is the c...
Source: Vaccine - April 10, 2015 Category: Allergy & Immunology Authors: Schrager L, Aerosol Vaccines for Tuberculosis Workshop Summary Group Tags: Vaccine Source Type: research

Developing vaccines to prevent sustained infection with Mycobacterium tuberculosis: Conference proceedings: November 7, 2014, National Institute of Allergy and Infectious Diseases, Rockville, Maryland USA.
Abstract On November 7, 2014, Aeras and the National Institute of Allergy and Infectious Diseases convened a conference entitled "Conference on Vaccine Prevention of Sustained Mycobacterium tuberculosis Infection." The purpose of this meeting was to explore the biologic plausibility, potential public health and economic impact, and regulatory feasibility in attempting to develop a vaccine to prevent sustained infection with Mycobacterium tuberculosis (Mtb). Currently there are two main goals for tuberculosis (TB) vaccine development, to develop a vaccine that could serve as a booster to Bacille Calmette-Guérin (B...
Source: Vaccine - April 10, 2015 Category: Allergy & Immunology Authors: Schrager L, Vaccine Prevention of Sustained Mycobacterium tuberculosis Infection Summary Group Tags: Vaccine Source Type: research