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Infectious Disease: Aspergillus

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Total 481 results found since Jan 2013.

Superoxide dismutase reduces the inflammatory response to Aspergillus and Alternaria in human sinonasal epithelial cells derived from patients with chronic rhinosinusitis.
CONCLUSIONS: When HSNECs from CRSwNP patients are treated with SOD concurrently with Aspergillus or Alternaria, SOD treatment decreases the fungal antigen-induced inflammatory response. The ability to attenuate inflammation induced by common fungal allergens with SOD treatment could provide a novel therapeutic or preventative approach for patients with CRS or other allergic inflammatory airway diseases. PMID: 25785747 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - March 1, 2015 Category: ENT & OMF Authors: Lawrence LA, Mulligan JK, Roach C, Pasquini WN, Soler ZM, Banglawala SM, Karnezis TT, Gudis DA, Schlosser RJ Tags: Am J Rhinol Allergy Source Type: research

Molecular‐based allergy diagnosis of allergic bronchopulmonary aspergillosis in Aspergillus fumigatus‐sensitized Japanese patients
Conclusions & Clinical RelevanceThe levels of IgE to Asp f 1 and/or Asp f 2 can effectively differentiate ABPA from Af‐sensitized asthma, suggesting that the amounts of IgE specific for these molecules are markers for genuine Af‐sensitization in ABPA. However, comorbid AD must be taken into consideration in the interpretation of high IgE to Asp f 6. Establishing of IgE‐sensitization profiles using panel of Af‐allergen components provides valuable information for distinguishing genuine versus cross‐reactive sensitization in Af‐sensitized patients.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - June 28, 2015 Category: Allergy & Immunology Authors: Hidenori Tanimoto, Yuma Fukutomi, Hiroshi Yasueda, Yasuo Takeuchi, Akemi Saito, Kentaro Watai, Kiyoshi Sekiya, Takahiro Tsuburai, Koichiro Asano, Masami Taniguchi, Kazuo Akiyama Tags: Original Article‐Allergens Source Type: research

Alternaria Induces Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2.
CONCLUSIONS: The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especially in CRS with nasal polyps. PMID: 26540503 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 7, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Identification of Aspergillus (A flavus and A niger) Allergens and Heterogeneity of Allergic Patients' IgE Response.
We report a study on the identification of major and minor allergens of the two common airborne Aspergillus species and heterogeneity of patients' IgE response to them.Skin prick tests were performed on 300 patients of bronchial asthma and/or allergicrhinitis and 20 healthy volunteers. Allergen specific IgE in patients' sera was estimated by enzyme allergosorbent test (EAST). Immunoblots were performed to identify major/minor allergens of Aspergillus extracts and to study heterogeneity of patients'IgE response to them. Positive cutaneous responses were observed in 17% and 14.7% of patients with A flavusand A niger extracts...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Vermani M, Kandi-Vijayan V, Kumar-Agarwal M Tags: Iran J Allergy Asthma Immunol Source Type: research

Eosinophilic Granulomatosis with Polyangiitis preceding allergic bronchopulmonary aspergillosis.
Authors: Lee W, Teo FS, Santosa A, Teng GG Abstract A 61-year-old Chinese man with long-standing, stable Eosinophilic Granulomatosis with Polyangiitis (EGPA) and asthma, presented with acute hypoxemia and declining obstructive pulmonary function. Elevated serum IgE levels, positive Aspergillus fumigatus specific IgE and CT findings of central bronchiectasis with small airway mucoid impaction confirmed new development of Allergic Bronchopulmonary Aspergillosis (ABPA). The maintenance therapy for EGPA, azathioprine, was discontinued. Prednisolone 0.5mg/kg/day and Itraconazole improved his symptoms and IgE levels. To ...
Source: European Annals of Allergy and Clinical Immunology - November 11, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Allergic Bronchopulmonary Aspergillosis: A Perplexing Clinical Entity.
Authors: Shah A, Panjabi C Abstract In susceptible individuals, inhalation of Aspergillus spores can affect the respiratory tract in many ways. These spores get trapped in the viscid sputum of asthmatic subjects which triggers a cascade of inflammatory reactions that can result in Aspergillus-induced asthma, allergic bronchopulmonary aspergillosis (ABPA), and allergic Aspergillus sinusitis (AAS). An immunologically mediated disease, ABPA, occurs predominantly in patients with asthma and cystic fibrosis (CF). A set of criteria, which is still evolving, is required for diagnosis. Imaging plays a compelling role in th...
Source: Allergy, Asthma and Immunology Research - April 30, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Allergic bronchopulmonary aspergillosis complicating Swyer-James-Macleod's syndrome: case report and review of literature.
Authors: Sehgal IS, Dhooria S, Behera D, Agarwal R Abstract Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that results from immune responses mounted against antigens of Aspergillus fumigatus, resulting in non-specific respiratory symptoms and structural lung damage. Classically defined in individuals suffering from bronchial asthma and cystic fibrosis, ABPA has recently been described in other lung diseases including COPD, pulmonary tuberculosis, idiopathic bronchiectasis and others. Herein, we report the first case of ABPA complicating Swyer-James-Macleod's syndrome that was successfully t...
Source: European Annals of Allergy and Clinical Immunology - May 8, 2016 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Effect of eosinophils activated with Alternaria on the production of extracellular matrix from nasal fibroblasts.
CONCLUSIONS: Eosinophils activated with Alternaria enhanced ECM mRNA expression from nasal polyp fibroblasts. Alternaria plays an important role in tissue fibrosis in the pathogenesis of nasal polyps by directly or indirectly influencing the production of ECM from nasal fibroblasts. PMID: 27156749 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 2, 2016 Category: Allergy & Immunology Authors: Shin SH, Ye MK, Choi SY, Kim YH Tags: Ann Allergy Asthma Immunol Source Type: research

Evaluation of the association between sensitization to common inhalant fungi and poor asthma control.
CONCLUSION: Sensitization to fungi is predominant in men, and it is associated with poor asthma control. In particular, sensitization to Penicillium and Aspergillus is a risk factor for asthma severity. These results have potential relevance in asthma management. PMID: 27499543 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - July 31, 2016 Category: Allergy & Immunology Authors: Tanaka A, Fujiwara A, Uchida Y, Yamaguchi M, Ohta S, Homma T, Watanabe Y, Yamamoto M, Suzuki S, Yokoe T, Sagara H Tags: Ann Allergy Asthma Immunol Source Type: research

Clinical and radiological signs of ABPA associated with airways infection with Aspergillus in the absence of specific IgE.
In conclusion, clinical and radiological signs of ABPA can be associated with Aspergillus infection also in the absence of a specific serum antibody reaction. PMID: 27608478 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - September 10, 2016 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Chronic granulomatous disease as an SOS call for multicenter cooperative effort to prevent infections: A meta-analysis of the treatments.
CONCLUSION: Despite the fact that interferon gamma prophylaxis seems to have a positive effect on severe infections, small sample sizes preclude definite conclusions. Further trials with interferon gamma and/or antifungal and antibiotics are necessary to optimize the treatment of CGD. PMID: 27613462 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - August 31, 2016 Category: Allergy & Immunology Authors: Loffredo L, Perri L, Zicari A, Del Ben M, Angelico F, Violi F Tags: Ann Allergy Asthma Immunol Source Type: research

Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics.
Authors: Ghebre MA, Desai D, Singapuri A, Woods J, Rapley L, Cohen S, Herath A, Wardlaw AJ, Pashley CH, May R, Brightling CE Abstract Aspergillus fumigatus sensitization and culture in asthma are associated with disease severity and lung function impairment, but their relationship with airway inflammation is poorly understood. We investigated the profile of 24 sputum inflammatory mediators in A. fumigatus culture-positive or-negative moderate-to-severe asthmatics. Fifty-two subjects were recruited from a single center. A. fumigatus was cultured from 19 asthmatics. Asthma control, symptom score, lung function, and s...
Source: Allergy, Asthma and Immunology Research - January 21, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Association of atopy phenotypes with new development of asthma and bronchial hyperresponsiveness in school-aged children.
CONCLUSION: Identification of atopy phenotypes facilitates prediction of the development of asthma and bronchial hyperresponsiveness in school-age children. Our study suggests prevention of additional sensitization is required to modify the progression of allergic diseases. PMID: 28364972 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 29, 2017 Category: Allergy & Immunology Authors: Lee E, Lee SH, Kim YH, Cho HJ, Yoon J, Yang SI, Jung YH, Kim HY, Seo JH, Kwon JW, Kim HB, Lee SY, Kwon HJ, Hong SJ Tags: Ann Allergy Asthma Immunol Source Type: research

Clinical and radiological signs of ABPA associated with airways infection with Aspergillus in the absence of specific IgE.
In conclusion, clinical and radiological signs of ABPA can be associated with Aspergillus infection also in the absence of a specific serum antibody reaction. PMID: 27608478 [PubMed - indexed for MEDLINE]
Source: European Annals of Allergy and Clinical Immunology - June 15, 2017 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Characteristics of severe asthma with fungal sensitization.
CONCLUSION: Severe asthma with fungal sensitization is characterized by early onset of disease and high serum levels of interleukin-33. Multiple fungal sensitizations are associated with poor asthma control. TRIAL REGISTRATION: UMIN Clinical Trials Registry (UMIN-CTR; www.umin.ac.jp/ctr/index-j.htm): UMIN 000002980. PMID: 28801088 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - August 8, 2017 Category: Allergy & Immunology Authors: Masaki K, Fukunaga K, Matsusaka M, Kabata H, Tanosaki T, Mochimaru T, Kamatani T, Ohtsuka K, Baba R, Ueda S, Suzuki Y, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Kamei K, Izuhara K, Asano K, Betsuyaku T Tags: Ann Allergy Asthma Immunol Source Type: research