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Total 442 results found since Jan 2013.
VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC.
In this study, VAOS exhibited effective inhibitory effects in NSCLC both in cultured cells and in a xenograft mouse model. VAOS was further identified to induce NSCLC cell apoptosis through activating protein kinase B (AKT) to elevate intracellular reactive oxygen species (ROS) levels by increasing in oxygen consumption and impairing the ROS-scavenging system. Neither silencing of PTP1B by siRNA nor transient overexpression of PTP1B had an effect on the AKT phosphorylation triggered by VAOS, indicating that PTP1B inhibition was not involved in VAOS-induced apoptosis. Through phosphorus colorimetric assay, we demonstrated t...
Source: Free Radical Biology and Medicine - September 14, 2018 Category: Biology Authors: Zhou L, Yi Y, Yuan Q, Zhang J, Li Y, Wang P, Xu M, Xie S Tags: Free Radic Biol Med Source Type: research
Caffeic Acid Attenuates Rat Liver Injury after Transplantation Involving PDIA3-Dependent Regulation of NADPH Oxidase.
This study was undertaken to explore the effect of Caffeic acid (CA), a naturally occurring antioxidant, on I/R injury of grafted liver and the mechanisms involved. Male Sprague-Dawley rats underwent orthotopic liver transplantation (LT) in the absence or presence of CA administration. In vitro, HL7702 cells were subjected to hypoxia/reoxygenation. LT led to apparent hepatic I/R injury, manifested by deteriorated liver function, microcirculatory disturbance and increased apoptosis, along with increased PDIA3 expression and nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase activity, and membrane translocation of...
Source: Free Radical Biology and Medicine - September 12, 2018 Category: Biology Authors: Mu HN, Li Q, Fan JY, Pan CS, Liu YY, Yan L, Sun K, Hu BH, Huang DD, Zhao XR, Chang X, Wang CS, He SY, He K, Yang BX, Han JY Tags: Free Radic Biol Med Source Type: research
Bub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells.
Abstract
Error-free chromosome segregation during mitosis depends on a functional spindle assembly checkpoint (SAC). The SAC is a multi-component signalling system that is recruited to unattached or incorrectly attached kinetochores to catalyse the formation of a soluble inhibitor, known as the Mitotic Checkpoint Complex (MCC), which binds and inhibits the anaphase promoting complex (APC/C) [1]. We have previously proposed that two separable pathways, composed of KNL1-Bub3-Bub1 (KBB) and Rod-Zwilch-Zw10 (RZZ), recruit Mad1-Mad2 complexes to human kinetochores to activate the SAC [2]. Although Bub1 is absolutely re...
Source: Current Biology - September 10, 2018 Category: Biology Authors: Currie CE, Mora-Santos M, Smith CA, McAinsh AD, Millar JBA Tags: Curr Biol Source Type: research
Growth arrest and DNA-damage-inducible 45 beta (GADD45β) deletion suppresses testosterone-induced prostate hyperplasia in mice
Publication date: Available online 6 September 2018Source: Life SciencesAuthor(s): Se-Ra Park, Da-Young Jung, Tae-Won Kim, Chul-Ho Lee, Ju-Young JungAbstractAimGrowth arrest and DNA-damage-inducible 45 beta (GADD45β) is a member of the gene family associated with cell growth control, apoptosis, and DNA damage repair. The aim of present study was to determine the potential effects of GADD45β deletion on prostate hyperplasia progression.Main methodsLNCaP cells were incubated with testosterone propionate (1 μM) for 48 h and specific siRNA used to suppress GADD45β expression in vitro. For in vivo experiments, testoster...
Source: Life Sciences - September 6, 2018 Category: Biology Source Type: research
AMPK/PGC1 α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis.
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis.
Free Radic Biol Med. 2018 Aug 30;:
Authors: Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J
Abstract
Doxorubicin (DOX) is a highly effective anticancer anthracycline drug, but its side effects at the level of the heart has limited its widespread clinical application. Melatonin is a documented potent antioxidant, nontoxic and cardioprotective agent, and it is involved in maintaining mitochondrial homeostasis and function. The present study esta...
Source: Free Radical Biology and Medicine - August 30, 2018 Category: Biology Authors: Liu D, Ma Z, Di S, Yang Y, Yang J, Xu L, Reiter RJ, Qiao S, Yuan J Tags: Free Radic Biol Med Source Type: research
Axis of serotonin -pERK-YAP in liver regeneration
ConclusionA role of the 5-HT-pERK-YAP axis in liver regeneration emerged from our study and might be a potential target to promote regeneration and injury repair.
Source: Life Sciences - August 21, 2018 Category: Biology Source Type: research
Small Interfering RNA based knock down of acute heat shock and or GGA inducible bovine heat shock protein 70 may interfere invitro expression pattern of TLR2/4 and NOD1/2
This study may add some references pertaining to the innate immune modulatory effects of bovine heat shock protein 70.
Source: Journal of Thermal Biology - August 21, 2018 Category: Biology Source Type: research
Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice
In this study, we investigated the effects of the progression of SCI and potential regulation of apoptosis after the Pleckstrin homology (PH) domain and leucine rich repeat protein phosphatase 1 (PHLPP1) gene was silenced.Main methodsSpinal cord injection, and neuronal transfection with a recombinant adenovirus vector encoding small interfering RNA (siRNA) against PHLPP1 (AdsiPHLPP1) successfully silenced PHLPP1. These created in vivo and in vitro PHLPP1-silenced models, respectively, resulting in stable expression of the transgene in neurons.Key findingsThe results showed that silencing of PHLPP1 evidently reduced levels ...
Source: Life Sciences - August 13, 2018 Category: Biology Source Type: research
A mannose receptor is involved in the anti-Vibrio defense of red swamp crayfish
Publication date: Available online 9 August 2018Source: Fish & Shellfish ImmunologyAuthor(s): Xin Man, Xin-Tong Pan, Hong-Wei Zhang, Yue Wang, Xin-Cang Li, Xiao-Wen ZhangAbstractMannose receptor (MR), a member of pattern-recognition receptors (PRRs), is the first MR family member to be discovered that plays a critical role in immunity. The function of MRs has been reported in mammals and teleosts while none in invertebrates. In the present study, we identified a MR-like gene (designated as PcMR) from red swamp crayfish, Procambarus clarkii. The PcMR cDNA is 6848 bp long with a 6288 bp open reading frame that encodes a poly...
Source: Fish and Shellfish Immunology - August 10, 2018 Category: Biology Source Type: research
Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer
In this study, we found that overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. The NNT is considered a key antioxidative enzyme based on its ability to regenerate NADPH from NADH. Knockdown of NNT caused significantly NADPH reduction, induced high levels of ROS and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. In vivo experiments showed that NNT promoted tumor growth, lung metastasis and peritoneal dissemination of gastric cancer. Moreover, intratumoral injection of NNT siRNA ...
Source: Redox Biology - July 22, 2018 Category: Biology Source Type: research
Regulation of apolipoprotein A-I gene expression by the histamine H1 receptor: Requirement for NF-κB
Publication date: 1 September 2018Source: Life Sciences, Volume 208Author(s): Michael J. Haas, Marilu Jurado-Flores, Ramadan Hammoud, Gabriela Plazarte, Luisa Onstead-Haas, Norman C.W. Wong, Arshag D. MooradianAbstractAimsEarlier it had been found by us that apolipoprotein A-I (apo A-I) is suppressed by histamine in HepG2 cells. Histamine has been shown to regulate NF-κB activity, though not in hepatocytes. Therefore we examined the role of the histamine receptors and NF-κB in histamine-mediated apo A-I gene expression in HepG2 liver cells.Main methodsThe effect of histamine on histamine H1 receptor expression, and NF-κ...
Source: Life Sciences - July 19, 2018 Category: Biology Source Type: research
Molecular cloning and functional characterisation of NLRX1 in grass carp (Ctenopharyngodon idella)
Publication date: October 2018Source: Fish & Shellfish Immunology, Volume 81Author(s): Pengfei Chu, Libo He, Yangyang Li, Rong Huang, Lanjie Liao, Yongming Li, Zuoyan Zhu, Yaping WangAbstractThe nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. In the present study, the NLR family gene NLRX1 from grass carp (Ctenopharyngodon idella) was cloned and characterised. NLRX1 was widely expressed in all tissues examined, albeit at varying levels. After exposure to the grass carp...
Source: Fish and Shellfish Immunology - July 18, 2018 Category: Biology Source Type: research
Functional domains of Litopenaeus vannamei transglutaminase and their involvement in immunoregulation in shrimp
Publication date: October 2018Source: Fish & Shellfish Immunology, Volume 81Author(s): Zhou Zheng, Wenning Xu, Jude Juventus Aweya, Mingqi Zhong, Shangjie Liu, Jingsheng Lun, Jiehui Chen, Yueling ZhangAbstractShrimps, which mainly rely on their innate immune system to response to infectious pathogens, have clottable proteins as an important component of this system. While transglutaminases (TGase) are found in Litopenaeus vannamei and constitute part of the coagulation system, the specific immune-related roles played by its functional domains in the immunoregulation of shrimp has not been well understood. In the present st...
Source: Fish and Shellfish Immunology - July 18, 2018 Category: Biology Source Type: research
Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA
Publication date: September 2018Source: Redox Biology, Volume 18Author(s): Wenjing Hao, Tianyang Qi, Lang Pan, Ruoxi Wang, Bing Zhu, Leopoldo Aguilera-Aguirre, Zsolt Radak, Tapas K. Hazra, Spiros A. Vlahopoulos, Attila Bacsi, Allan R. Brasier, Xueqing Ba, Istvan BoldoghAbstract8-Oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair pathway by removing one of the most abundant DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). Recent data showed that 8-oxoG not only is a pro-mutagenic genomic base lesion, but also functions as an epigenetic mark and that consequently OGG1 acquire distinct roles in modulation o...
Source: Redox Biology - July 11, 2018 Category: Biology Source Type: research
High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease
Publication date: July 2018Source: Redox Biology, Volume 17Author(s): Firas Alhasson, Ratanesh Kumar Seth, Sutapa Sarkar, Diana A. Kimono, Muayad S. Albadrani, Diptadip Dattaroy, Varun Chandrashekaran, Geoffrey I. Scott, Samir Raychoudhury, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh ChatterjeeAbstractHigh circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E1-mediated oxidative stress and circulating leptin in NAFLD...
Source: Redox Biology - July 11, 2018 Category: Biology Source Type: research
