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Specialty: Drugs & Pharmacology
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Total 1993 results found since Jan 2013.
Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression
CONCLUSIONS: Baicalein preserved the BLM-induced downregulation of lung Sirt3 expression, and thus the suppression of TGF-β1/Smad signalling pathway and lung fibrosis, which might provide an experimental basis for treatment of IPF.PMID:36815239 | DOI:10.1080/13880209.2022.2160767
Source: Pharmaceutical Biology - February 23, 2023 Category: Drugs & Pharmacology Authors: Yuan Ji-Hong Ma Yu Yuan Ling-Hong Gong Jing-Jing Xu Ling-Li Wang Lv Jin Yong-Mei Source Type: research
COMMD5 is involved in the mechanisms of hypotension after parathyroidectomy in patients receiving hemodialysis
CONCLUSIONS: Serum COMMD5 levels were increased after PTx in SHPT patients. COMMD5 promoted high expression of ANP and eNOS in endothelial cells, leading to vasodilation and resulting in hypotension.PMID:36804542 | DOI:10.1016/j.ejphar.2023.175596
Source: European Journal of Pharmacology - February 22, 2023 Category: Drugs & Pharmacology Authors: Bohou Li Xueqin Chen Juan Hu Guibao Ke Nan Jiang Fengxia Zhang Zhiwen Lian Sichun Wen Qiong Wu Yubin Xia Hong Zhang Sujuan Kuang Lixia Xu Chunyu Deng Shuangxin Liu Source Type: research
Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly- γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC
Drug Dev Ind Pharm. 2023 Feb 20:1-18. doi: 10.1080/03639045.2023.2182125. Online ahead of print.ABSTRACTDue to the complexity of pathophysiology of non-small cell lung cancer (NSCLC) and susceptibility of single chemotherapy to drug resistance, the combination of drugs and small interfering RNA (siRNA) may produce desired therapeutic effect on NSCLC through action of multiple pathways. We designed to develop poly-γ-glutamic acid-modified cationic liposomes (γ-PGA-CL) to co-deliver pemetrexed disodium (PMX) and siRNA to treat NSCLC. Firstly, γ-PGA was modified on surface of PMX and siRNA co-loaded cationic liposomes by e...
Source: Drug Development and Industrial Pharmacy - February 21, 2023 Category: Drugs & Pharmacology Authors: Huang Xiaoyu Song Ruonan Wang Xiao Kongfang He Rumeng Shan Xie Fei Guihua Huang Source Type: research
Ablation of shank1 protects against 6-OHDA-induced cytotoxicity via PRDX3-mediated inhibition of ER stress in SN4741 cells
CONCLUSION: In summary, the present study has provided the first evidence that the knockdown of shank1 protects against 6-OHDA-induced ER stress and mitochondrial dysfunction through activating the PRDX3 pathway.PMID:36797610 | DOI:10.2174/1871527322666230216124156
Source: CNS and Neurological Disorders Drug Targets - February 16, 2023 Category: Drugs & Pharmacology Authors: Ye-Ping Xu Jing Zhang Xue Mei Yan Wu Wei Jiao Yu-Hai Wang Ai-Qin Zhang Source Type: research
Tetramethylpyrazine Attenuates Oxygen-glucose Deprivation-induced Neuronal Damage through Inhibition of the HIF-1 α/BNIP3 Pathway: From Network Pharmacological Finding to Experimental Validation
CONCLUSION: Our study shows that TMP protects OGD-damaged PC12 cells by inhibiting the HIF-1α/BNIP3 pathway, which provides new insights into the mechanism of TMP and its neuroprotective potential.PMID:36790003 | DOI:10.2174/1381612829666230215100507
Source: Current Pharmaceutical Design - February 15, 2023 Category: Drugs & Pharmacology Authors: Shixin Xu Nannan Zhang Lanlan Cao Lu Liu Hao Deng Shengyu Hua Yunsha Zhang Source Type: research
Pharmacokinetics of Jnj-73763989 And Jnj-56136379 (Bersacapavir) In Participants With Moderate Hepatic Impairment
This article is protected by copyright. All rights reserved.PMID:36786053 | DOI:10.1002/jcph.2214
Source: The Journal of Clinical Pharmacology - February 14, 2023 Category: Drugs & Pharmacology Authors: Thomas N Kakuda Atef Halabi Gernot Klein Madhu Sanga Carine Guinard-Azadian Monika Kowalik Katja Nedoschinsky Julius Nangosyah Emmanuel Njumbe Ediage Vera Hillewaert Peter Verboven Ivo Goris Jan Snoeys Martyn Palmer Michael Biermer Source Type: research
