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Total 190 results found since Jan 2013.
Protocatechuic Acid from Alpinia oxyphylla Induces Schwann Cell Migration via ERK1/2, JNK and p38 Activation.
This study investigated the role of PCA in promoting neural regeneration and the underlying molecular mechanisms. Nerve regeneration is a complex physiological response that takes place after injury. Schwann cells play a crucial role in the endogenous repair of peripheral nerves due to their ability to proliferate and migrate. The role of PCA in Schwann cell migration was determined by assessing the induced migration potential of RSC96 Schwann cells. PCA induced changes in the expression of proteins of three MAPK pathways, as determined using Western blot analysis. In order to determine the roles of MAPK (ERK1/2, JNK, and ...
Source: The American Journal of Chinese Medicine - June 28, 2015 Category: Complementary Medicine Authors: Ju DT, Kuo WW, Ho TJ, Paul CR, Kuo CH, Viswanadha VP, Lin CC, Chen YS, Chang YM, Huang CY Tags: Am J Chin Med Source Type: research
Neuroprotection of Sanhua Decoction against Focal Cerebral Ischemia/Reperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4.
In conclusion, SHD exerted neuroprotection against focal cerebral I/R injury in rats mainly through a mechanism targeting AQP4.
PMID: 26089944 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - June 21, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
In conclusion, Rg3 induces tumor cell apoptosis correlated with its inhibitory effect on NF-κB signaling pathway-mediated FUT4 expression. Results suggest Rg3 might be a novel therapy agent for melanoma treatment.
PMID: 26094873 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - June 18, 2015 Category: Cancer & Oncology Authors: Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW Tags: Int J Oncol Source Type: research
Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway
Conclusion: The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells.Cell Physiol Biochem 2015;36:956-965
Source: Cellular Physiology and Biochemistry - June 16, 2015 Category: Cytology Source Type: research
NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway
Conclusion: Taken together, this study provides that BMX might modulate cisplatin resistance through AMPK-ERK and AMPK-Akt pathways. These results also support the role of BMX as a potential drug candidate for use in combination with cisplatin in the treatment of human lung cancer.Cell Physiol Biochem 2015;36:893-906
Source: Cellular Physiology and Biochemistry - June 9, 2015 Category: Cytology Source Type: research
Ursolic acid protects hepatocytes against lipotoxicity through activating autophagy via an AMPK pathway
Publication date: August 2015 Source:Journal of Functional Foods, Volume 17 Author(s): Fanyu Meng , Hua Ning , Zongxiang Sun , Fangfang Huang , Yanchuan Li , Xia Chu , Huimin Lu , Changhao Sun , Songtao Li Ursolic acid is a naturally occurring pentacyclic triterpenoid in many plants, such as medicinal herbs and food, and was previously found to be an effective phytochemical that protected against high-fat diet-induced hepatic steatosis and liver injury. However, the molecular mechanisms are not fully determined. The present study examined the protective role of ursolic acid against saturated fatty acid-induced lipotoxici...
Source: Journal of Functional Foods - June 7, 2015 Category: Nutrition Source Type: research
Par‐4 dependent modulation of cellular β‐catenin by medicinal plant natural product derivative 3‐azido Withaferin A
This study, for the first time, reveals 3‐AWA treatment consistently sequestered nuclear β‐catenin and augmented its cytoplasmic pool as evidenced by reducing β‐catenin transcriptional activity in these cells. Moreover, 3‐AWA treatment triggered robust induction of pro‐apoptotic intracellular Par‐4, attenuated Akt activity and rescued Phospho‐GSK3β (by Akt) to promote β‐catenin destabilization. Further, our in vitro studies demonstrate that 3‐AWA treatment amplified E‐cadherin expression along with sharp downregulation of c‐Myc and cyclin D1 proteins. Strikingly, endogenous Par‐4 knock down by s...
Source: Molecular Carcinogenesis - May 12, 2015 Category: Molecular Biology Authors: Hina Amin, Debasis Nayak, Reyaz ur Rasool, Souneek Chakraborty, Anmol Kumar, Khalid Yousuf, Parduman Raj Sharma, Zabeer Ahmed, Neelam Sharma, Asmita Magotra, Debaraj Mukherjee, Lekha Dinesh Kumar, Anindya Goswami Tags: Research Article Source Type: research
Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway
Conclusions:
Taken together, these results suggest that a NOX4-dependent pathway plays an important role in regulating the inhibitory effect of QYGS. Our findings provide new insights into the molecular mechanisms of QYYYG and their role in the treatment of hypertensive nephropathy.
Source: BMC Complementary and Alternative Medicine - March 25, 2015 Category: Complementary Medicine Authors: Kang DingYan WangWeimin JiangYu ZhangHongping YinZhuyuan Fang Source Type: research
Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.
In conclusion, Rg3 effectively inhibited melanoma cell growth by downregulating FUT4 both in vitro and in vivo. Targeting FUT4/LeY mediated fucosylation by Rg3 inhibited the activation of EGFR/MAPK pathway and prevented melanoma growth. Results from this study suggest Rg3 is a potential novel therapy agent for melanoma treatment.
PMID: 25672851 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - February 10, 2015 Category: Cancer & Oncology Authors: Shan X, Aziz F, Tian LL, Wang XQ, Yan Q, Liu JW Tags: Int J Oncol Source Type: research
Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43
Conclusions:
G. lucidum inhibits ovarian cancer by down-regulating the expression of VEGF and up-regulating the downstream Cx43 expression. G. lucidum may be a promising therapeutic agent for the treatment of ovarian cancer.
Source: BMC Complementary and Alternative Medicine - November 5, 2014 Category: Complementary Medicine Authors: Shuyan DaiJingjing LiuXiaofei SunNing Wang Source Type: research
Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
Conclusions:
These findings suggest that the reduction of cell viability and apoptosis by GL may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression through ERK1/2 activation in human colorectal cancer cells.
Source: BMC Complementary and Alternative Medicine - October 23, 2014 Category: Complementary Medicine Authors: Gwang Hun ParkJae Ho ParkHun Min SongHyun Ji EoMi Kyoung KimJin Wook LeeMan Hyo LeeKiu-Hyung ChoJeong Rak LeeHyeon Je ChoJin Boo Jeong Source Type: research
Abstract 1255: The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells
Conclusion: Rosemary induces ER stress-mediated apoptotic cell death in prostate cancer cell lines, 22Rv1and LNCaP cells, leading to disruption of AR expression. Our data suggests that this Mediterranean dietary phytochemical possess strong anticancer activity and should be evaluated further as potential chemopreventive and/or chemotherapeutic agent for controlling prostate cancer.
Citation Format: Sakina M. Petiwala, Saba Berhe, Gongbo Li, Angela G. Puthenveetil, Larisa Nonn, Jeremy J. Johnson. The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells. [...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Petiwala, S. M., Berhe, S., Li, G., Puthenveetil, A. G., Nonn, L., Johnson, J. J. Tags: Prevention Research Source Type: research
Abstract 4110: Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis
Conclusions: Our study demonstrated that gartanin inhibited proliferation and induced apoptosis on prostate cancer cells in vitro. It achieves its anticancer effects partly through inhibiting AR and promoting ER stress. The ability of gartanin to inhibit prostate cancer cells suggests further research is needed to evaluate gartanin as a novel agent for the management of prostate cancer.
Citation Format: Gongbo Li, Sakina Petiwala, Jeremy Johnson. Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis. [abstract]. In: Proceedings of the 105th Annua...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Li, G., Petiwala, S., Johnson, J. Tags: Prevention Research Source Type: research
Abstract 2335: Thymoquinone induces the MUC4 mRNA-destabilizing activity of Tristetraprolin
In this study, we investigate that Tymoquinone (TQ) which is an active ingredient derived from the medicinal plant Nigella satia induces the TTP mRNA and protein expression in AGS and MDA-MB231. TQ treatment destabilized a luciferase mRNA containing cIAP2, VEGF and MUC4 ARE. Transfected cells were treated with various kinds of MAPK inhibitors, treatment with Sorafenib (RAF inhibitor) and U0126 (MEK-1/2) reduced the TTP induction activity of TQ in a dose-dependent manner. We confirmed that co-treatment with sorafenib/U0126 and TQ also reduced TTP expression. Following TQ downregulated the expression of MUC4 in previous stud...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lee, H. H., Lee, S.-R., Leem, S.-H. Tags: Molecular and Cellular Biology Source Type: research
Involvement of C/EBPβ in monocytic differentiation of acute myeloid leukemia cells induced by LW-218, a new synthesized flavonoid.
In this study, we found that LW-218, a new synthesized flavonoid, inhibited proliferation and induced differentiation of acute myeloid leukemia cells. The IC50s of LW-218 in HL-60, U937, K562, and NB4 cell lines were all less than 5 μM, suggesting greater capacity than compounds we have reported. LW-218 induced differentiation effects including morphologic changes, NBT reduction, and both of CD11b and CD14 expression. Results of western blots and siRNA transfection revealed that LW-218 increased the LAP/LIP ratio of C/EBPβ which regulated monocytic differentiation of leukemia cells. Meanwhile, these differentiation eff...
Source: Neoplasma - August 23, 2014 Category: Cancer & Oncology Authors: Wang Q, Hui H, Yang H, Li H, Gao Y, Li Z, Guo Q, Lu N Tags: Neoplasma Source Type: research
