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Total 379 results found since Jan 2013.

Eosinophil ETosis and DNA Traps: a New Look at Eosinophilic Inflammation
Abstract The traditional paradigm of eosinophils as end-stage damaging cells has mainly relied on their release of cytotoxic proteins. Cytokine-induced cell survival and secretion of granular contents from tissue-dwelling eosinophil are thought to be important mechanisms for eosinophilic inflammatory disorders, although the occurrence of cytolysis and its products (i.e., free extracellular granules) has been observed in affected lesions. Recent evidence indicates that activated eosinophils can exhibit a non-apoptotic cell death pathway, namely extracellular trap cell death (ETosis) that mediates the eosinophil cy...
Source: Current Allergy and Asthma Reports - July 7, 2016 Category: Allergy & Immunology Source Type: research

Lessons learned from merging EHR systems
WASHINGTON – As practices merge, how hard is it to merge EHRs? Even in what might seem to be the best circumstances, it can be a huge challenge, according to Jacqueline Fincher, MD, of McDuffie Medical...
Source: Skin and Allergy News - July 21, 2016 Category: Dermatology Source Type: news

' I ' ll Be Watching You ' -- Antibiotic Stewardship Meets Ambulatory Care ' I ' ll Be Watching You ' -- Antibiotic Stewardship Meets Ambulatory Care
Most antimicrobial stewardship programs have focused on hospitals, yet most prescribing takes place in ambulatory care. How can we apply stewardship lessons to outpatient settings? Society for Healthcare Epidemiology of America (SHEA)
Source: Medscape Allergy Headlines - July 26, 2016 Category: Allergy & Immunology Tags: Infectious Diseases Viewpoint Source Type: news

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
Abstract Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR ( Contre les MAladies Chroniques pour un VIeillissement Actif ) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AI...
Source: Clinical and Translational Allergy - July 28, 2016 Category: Allergy & Immunology Source Type: research

A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin
Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, a...
Source: Allergy, Asthma and Clinical Immunology - August 5, 2016 Category: Allergy & Immunology Authors: Philippe Lefran çois, Hugo Chapdelaine, Benoît Côté and Martin Desrosiers Source Type: research

The diagnosis of adult-onset haemophagocytic lymphohistiocytosis: lessons learned from a review of 29 cases of bone marrow haemophagocytosis in two large academic institutions
Conclusions Since elevated ANC correlates with poor outcomes in sepsis, and not HLH, we postulate that many of the patients fulfilling HLH diagnostic criteria in this study likely had sepsis/systemic inflammatory response syndrome rather than HLH. Our results highlight the need to define HLH diagnostic criteria specific to the adult population.
Source: Journal of Clinical Pathology - August 16, 2016 Category: Pathology Authors: Rosado, F. G., Rinker, E. B., Plummer, W. D., Dupont, W. D., Spradlin, N. M., Reichard, K. K., Kim, A. S. Tags: Immunology (including allergy) Original article Source Type: research

Leading Digital Transformation
The freshly minted role of Chief Digital Officer is enjoying something of a boom.“At the end of 2015, there were approximately 2,000 CDOs. CDO hires have been doubling every year and I expect there to be 2,500 CDOs by the end of 2016,” the CDO Club’s CEO David Mathison noted recently.1But what ’s fuelling this trend? Quite simply, traditional businesses have woken up to the need fordigital transformation as customers demand new ways of engaging with businesses and the companies themselves look to improve the customer experience, streamline processes and reap the benefits of innovation down the length of the value ...
Source: EyeForPharma - August 18, 2016 Category: Pharmaceuticals Authors: Nick de Cent Source Type: news

Predicting improvement in diffuse scleroderma: lessons learnt
Dobrota et al1 have analysed the EUSTAR (EULAR Scleroderma Trials and Research) systemic sclerosis (SSc, scleroderma) database using a subset of diffuse cutaneous SSc (dcSSc) to determine predictors of skin improvement over 1 year in randomised trials. The idea is to enrol more informative patients in a randomised controlled trial (RCT), as incident dcSSc is rare. However, you could want patients who progress/worsen (if not on effective treatment) or those who regress/improve more when on treatment, or some of each subgroup in the sample studied. More than 900 patients were included in the EUSTAR early dcSSc study,1 a...
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: Pope, J. E. Tags: Immunology (including allergy), Connective tissue disease, Drugs: musculoskeletal and joint diseases, Epidemiology Editorials Source Type: research

Allergen-specific IgG as a mediator of allergy inhibition: Lessons from mother to child
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Source: Human Vaccines and Immunotherapeutics - November 2, 2016 Category: Allergy & Immunology Authors: Jefferson Russo Victor Source Type: research

Maculopapular rash after intravitreal injection of an antivascular endothelial growth factor, aflibercept, for treating age-related macular degeneration: A case report
Rationale: Aflibercept, an anti-vascular endothelial growth factor (VEGF) drug, is used for treatment of colon cancer as well as retinal diseases, including wet age-related macular degeneration (AMD). It is injected into the vitreous cavity of eyes for treatment of AMD. Although vascular suppression—including cardiovascular events—and local infection related to the injection procedure are well-known potential adverse events, pathological immune responses after intravitreal aflibercept (IVA) injection have not been described. Patient concerns: A 60-year-old Japanese man diagnosed with polypoidal choroidal vasculopathy ...
Source: Medicine - May 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Social Psychology May Help With Physician Error Disclosure
Deliberate practice, together with lessons from social psychology, can implement change in error disclosure
Source: Pulmonary Medicine News - Doctors Lounge - May 31, 2017 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Oncology, Ophthalmology, Orthopedics, ENT, Pathology Source Type: news

Immune development and environment: lessons from Amish and Hutterite children.
Abstract Children who grow up in traditional farm environments are protected from developing asthma and allergy. This 'farm effect' can be largely explained by the child's early life contact with farm animals, in particular cows, and their microbes. Our studies in Amish and Hutterite school children living on farms in the U.S. have further demonstrated that this protection is mediated through innate immune pathways. Although very similar with respect to ancestry and many lifestyle factors that are associated with asthma risk, Amish and Hutterites follow farming practices that are associated with profound differenc...
Source: Current Opinion in Immunology - August 24, 2017 Category: Allergy & Immunology Authors: Ober C, Sperling AI, von Mutius E, Vercelli D Tags: Curr Opin Immunol Source Type: research

Work productivity loss in mild to moderate COPD: lessons learned from the CanCOLD study
Little attention has been given to the impact of chronic obstructive pulmonary disease (COPD) on work productivity loss. Individuals with COPD are at risk of reduced working hours, absenteeism, presenteeism and early retirement [1]. Studies have been focused mostly on patients attending outpatient clinics [2], which exclude individuals with undiagnosed COPD, thus limiting the external validity of the findings. There are very few population-based cohort studies [3–6], few reports on presenteeism [5], and a lack of objective measures to define COPD [6]. There would be value in knowing the extent of work productivity lo...
Source: European Respiratory Journal - September 12, 2017 Category: Respiratory Medicine Authors: de Sousa Sena, R., Ahmed, S., Tan, W. C., Li, P. Z., Labonte, L., Aaron, S. D., Benedetti, A., Chapman, K. R., Walker, B., Fitzgerald, J. M., Hernandez, P., Maltais, F., Marciniuk, D. D., O'Donnell, D. E., Sin, D. D., Bourbeau, J., the CanCOLD Collaborati Tags: Asthma and allergy Original Articles: Research letters Source Type: research

What Recent History Has Taught Us About Responding to Emerging Infectious Disease Threats.
This article recounts selected outbreaks occurring during this period and highlights lessons that were learned that can be applied to the infectious disease threats that will inevitably be faced in the current presidential administration and beyond. PMID: 29132162 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - November 14, 2017 Category: Internal Medicine Authors: Paules CI, Eisinger RW, Marston HD, Fauci AS Tags: Ann Intern Med Source Type: research