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Total 379 results found since Jan 2013.

Schnitzler’s syndrome: lessons from 281 cases
Abstract Schnitzler’s syndrome is an autoinflammatory disorder characterized by the association of a monoclonal IgM (or IgG) gammopathy, a chronic urticarial rash, and signs and symptoms of systemic inflammation, including fever, arthralgias and bone pain. It was first described in 1972. This review summarizes the clinical features, efficacy of therapies, and follow-up data of the 281 cases that have been reported to date. Also, the results of skin histology, bone imaging, laboratory investigations, and studies of the pathogenesis will be discussed, including the pivotal role of interleukin-1 beta in this disorder.
Source: Clinical and Translational Allergy - December 5, 2014 Category: Allergy & Immunology Source Type: research

Vaccine evaluation: lessons from a meningococcal B vaccine
Vaccination is among the most effective public health interventions of the past century, with immunisations against some of the most common and devastating childhood infections already in use to great effect. The development of new vaccines depends on advances in the field of vaccinology that carry high monetary costs. In most countries, these costs pose an obstacle to adoption of new vaccines. To that end, together with the scientific evaluation of new vaccines, an economic evaluation is vital. This aims to determine whether investment in the proposed vaccine is worthwhile. In this article, we will examine one such case s...
Source: Archives of Disease in Childhood - May 18, 2015 Category: Pediatrics Authors: Sarfatti, A., Martinon-Torres, F., Nadel, S. Tags: Patients, Health policy, Vaccination programs, Immunology (including allergy), Drugs: infectious diseases, Meningitis, Vaccination / immunisation, Infection (neurology), Neonatal and paediatric intensive care, Paediatric intensive care, Health economics, Source Type: research

Primary immunodeficiency association with systemic lupus erythematosus: review of literature and lessons learned by the Rheumatology Division of a tertiary University Hospital at São Paulo
Publication date: Available online 1 September 2015 Source:Revista Brasileira de Reumatologia (English Edition) Author(s): Paolo Ruggero Errante, Sandro Félix Perazzio, Josias Brito Frazão, Neusa Pereira da Silva, Luis Eduardo Coelho Andrade Primary immunodeficiency disorders (PID) represent a heterogeneous group of diseases resulting from inherited defects in the development, maturation and normal function of immune cells; thus, turning individuals susceptible to recurrent infections, allergy, autoimmunity, and malignancies. In this retrospective study, autoimmune diseases (AIDs), in special systemic lupus erythe...
Source: Revista Brasileira de Reumatologia - September 1, 2015 Category: Rheumatology Source Type: research

Effects of Sex Hormones on Ocular Surface Epithelia: Lessons Learned from Polycystic Ovary Syndrome
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - October 22, 2015 Category: Cytology Authors: Flavio Mantelli, Costanzo Moretti, Ilaria Macchi, Giacomina Massaro‐Giordano, Maria Grazia Cozzupoli, Alessandro Lambiase, Stefano Bonini Tags: Mini‐Review Source Type: research

The common food additive carrageenan and the alpha-gal epitope
Antibodies to the oligosaccharide epitope galactose-α-1,3-galactose (alpha-gal) are of considerable interest because they are so prevalent, include all isotypes, and are specific to humans and Old World apes. Alpha-gal–mediated responses, including immediate and delayed anaphylaxis, appear to be increasing. In the recent review “The alpha-gal story: lessons learned from connecting the dots,” sources of exposure to the alpha-gal epitope were presented, with particular attention to cetuximab, mammalian meat products, and tick bites.
Source: Journal of Allergy and Clinical Immunology - October 27, 2015 Category: Allergy & Immunology Authors: Joanne K. Tobacman Tags: Correspondence Source Type: research

Environmental factors in schools determining exercise-induced symptoms in children
Conclusion: This study showed that any detectable level of cat allergen may be clinically significant.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Stelmach, I., Cichalewski, L., Stelmach, W., Podlecka, D., Jerzynska, J. Tags: 5.3 Allergy and Immunology Source Type: research

Pyrexia of unknown origin 90 years on: a paradigm of modern clinical medicine
In 1925, Sir Thomas Horder, a leading physician of his day, gave a lecture, published in this journal, entitled ‘Some cases of pyrexia without physical signs’. The paper highlighted what was already a familiar clinical presentation "which taxes our resources to the utmost". Fast-forward through 90 years of careful clinical description, technological innovation in diagnosis and treatment, emergent infections, novel diagnoses, demographic shifts, and radical changes in the health economy. Sir Thomas would find certain aspects familiar, and others revolutionary, in the differential diagnosis and management of...
Source: Postgraduate Medical Journal - November 25, 2015 Category: Journals (General) Authors: Brown, M. Tags: Sexual transmitted infections (viral), Editor's choice, Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Radiology, Clinical diagnostic tests, Radiology (diagnostics) PMJ 90th anniversary review Source Type: research

The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects
Source: Journal of Allergy and Clinical Immunology - January 1, 2016 Category: Allergy & Immunology Tags: Continuing Medical Education examination Source Type: research

The challenge of measuring IL‐33 in serum using commercial ELISA: Lessons from asthma
Conclusion and Clinical RelevanceIf IL‐33 is to be studied in the serum of asthma patients and other diseases, a more sensitive and specific assay method is required, which will be vital for further understanding and targeting of the IL‐33/IL‐1RL1 axis in human disease.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - February 1, 2016 Category: Allergy & Immunology Authors: M.E. Ketelaar, M.C. Nawijn, D.E. Shaw, G.H. Koppelman, I. Sayers Tags: Research Letter Source Type: research

T Regulatory Cell Biology in Health and Disease
Abstract Regulatory T (Treg) cells that express the transcription factor forkhead box protein P3 (FOXP3) play an essential role in enforcing immune tolerance to self tissues, regulating host-commensal flora interaction, and facilitating tissue repair. Their deficiency and/or dysfunction trigger unbridled autoimmunity and inflammation. A growing number of monogenic defects have been recognized that adversely impact Treg cell development, differentiation, and/or function, leading to heritable diseases of immune dysregulation and autoimmunity. In this article, we review recent insights into Treg cell biology and fun...
Source: Current Allergy and Asthma Reports - February 29, 2016 Category: Allergy & Immunology Source Type: research

Primary immunodeficiency association with systemic lupus erythematosus: review of literature and lessons learned by the Rheumatology Division of a tertiary university hospital at São Paulo, Brazil
Resumo As imunodeficiências primárias (IDP) representam um grupo heterogêneo de doenças resultantes de defeitos hereditários no desenvolvimento, na maturação e na função normal de células do sistema imunológico; assim, tornam os indivíduos suscetíveis a infecções recorrentes, alergia, autoimunidade e doenças malignas. Neste estudo retrospectivo descrevem-se doenças autoimunes (DAI), em especial o lúpus eritematoso sistêmico (LES), que surgiram associadas ao curso das IDP. Classicamente, a literatura descreve três grupos de IDP associadas ao LES: (1) deficiência de componentes da via do complemento, (2)...
Source: Revista Brasileira de Reumatologia - March 5, 2016 Category: Rheumatology Source Type: research

Meet The Italian Doctor Using Facebook To Fight Anti-Vaxxers
Shocked by the growing number of children who die from vaccine-preventable diseases in Italy -- as well as stories of parents who refuse to vaccinate their kids -- a professor of microbiology and virology has decided to take on anti-vaxxers where they spread misinformation: on Facebook. For the more than 20,000 followers of his Facebook page, Dr. Roberto Burioni, a professor at the Vita-Salute San Raffaele University in Milan, Italy, explains the science behind vaccines and uses scientific data to refute rumors about their dangers. When he is not citing scientific studies, he pegs hi...
Source: Healthy Living - The Huffington Post - April 12, 2016 Category: Consumer Health News Source Type: news

Cells to Society: Women's Empowerment / Nurse Scientists / Research News
This study investigates the patterns and factors associated with persistent high cotinine concentrations in a sample of urban children with asthma who had frequent emergency department visits.     Read more     ...
Source: Johns Hopkins University and Health Systems Archive - June 15, 2016 Category: Nursing Source Type: news