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Case studies expose deadly risk of mpox to people with untreated HIV
In June 2022, a young man in his 30s severely sick with mpox, the viral disease formerly known as monkeypox, was admitted to the Salvador Zubirán National Institute of Health Sciences and Nutrition hospital in Mexico City. Tests showed the patient was also HIV-positive, which he had not known, and that his blood had few CD4 cells, critical immune cells that HIV attacks. The man’s immune system was so weak it could not keep mpox in check and painful lesions kept spreading across his body, eating away at, or necrotizing, the flesh, according to HIV researcher Brenda Crabtree Ramirez, who was on his care team. Then the vir...
Source: Science of Aging Knowledge Environment - February 21, 2023 Category: Geriatrics Source Type: research

Case studies expose deadly risk of mpox in people with untreated HIV
In June 2022, a young man in his 30s severely sick with mpox, the viral disease formerly known as monkeypox, was admitted to the Salvador Zubirán National Institute of Health Sciences and Nutrition hospital in Mexico City. Tests showed the patient was also HIV-positive, which he had not known, and that his blood had few CD4 cells, critical immune cells that HIV attacks. The man’s immune system was so weak it could not keep mpox in check and painful lesions kept spreading across his body, eating away at, or necrotizing, the flesh, according to HIV researcher Brenda Crabtree Ramirez, who was on his care team. Then the vir...
Source: ScienceNOW - February 21, 2023 Category: Science Source Type: news

News at a glance: New gene therapy, Europe ’s drought, and a black hole’s photon ring
ARCHAEOLOGY Drought exposes ‘Spanish Stonehenge’ for study Scientists are rushing to examine a 7000-year-old stone circle in central Spain that had been drowned by a reservoir for decades and was uncovered after the drought plaguing Europe lowered water levels. Nicknamed the “Spanish Stonehenge”—although 2000 years older than the U.K. stone circle—the Dolmen of Guadalperal (above) was described by archaeologists in the 1920s. The approximately 100 standing stones, up to 1.8 meters tall and arranged around an oval open space, were submerged in the Valdecañas reservoir after the construction of a ...
Source: Science of Aging Knowledge Environment - August 25, 2022 Category: Geriatrics Source Type: research

There ’s a shortage of monkeypox vaccine. Could one dose instead of two suffice?
As the monkeypox outbreak grows, the preferred vaccine to combat it is in short supply—a problem that’s only getting worse now that countries are expanding access to the vaccine. But there is a strategy that could double overnight the number of people who can be vaccinated: use a single shot instead of the recommended two. Compelling data from monkey and human studies suggest a single dose of the vaccine—produced by Bavarian Nordic and sold under three different brand names—solidly protects against monkeypox, and that the second dose mainly serves to extend the durability of protection. The United Kingdom...
Source: Science of Aging Knowledge Environment - July 1, 2022 Category: Geriatrics Source Type: research

The Great Vaccine Race: Inside the Unprecedented Scramble to Immunize the World Against COVID-19
The cleverest of enemies thrive on surprise attacks. Viruses—and coronaviruses in particular—know this well. Remaining hidden in animal hosts for decades, they mutate steadily, sometimes serendipitously morphing into more effective and efficient infectious agents. When a strain with just the right combination of genetic codes that spell trouble for people makes the leap from animal to human, the ambush begins. Such was the case with SARS-CoV-2, the coronavirus behind COVID-19, and the attack was mostly silent and insidious at first. Many people infected with SARS-CoV-2 remained oblivious as they served as the v...
Source: TIME: Health - September 10, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Magazine Source Type: news

Coronavirus Is Likely to Become a Seasonal Infection Like the Flu, Top Chinese Scientists Warn
Chinese scientists say the novel coronavirus will not be eradicated, adding to a growing consensus around the world that the pathogen will likely return in waves like the flu. It’s unlikely the new virus will disappear the way its close cousin SARS did 17 years ago, as it infects some people without causing obvious symptoms like fever. This group of so-called asymptomatic carriers makes it hard to fully contain transmission as they can spread the virus undetected, a group of Chinese viral and medical researchers told reporters in Beijing at a briefing Monday. With SARS, those infected became seriously ill. Once they ...
Source: TIME: Health - April 28, 2020 Category: Consumer Health News Authors: Bloomberg Tags: Uncategorized COVID-19 News Desk overnight wire Source Type: news

Klebsiella pneumoniae ST258 Negatively Regulates the Oxidative Burst in Human Neutrophils
In conclusion, we unraveled a mechanism of immune evasion of Kpn KPC ST258, which may contribute to design more effective strategies for the treatment of these multi-resistant bacterial infections. Introduction Klebsiella pneumoniae (Kpn) is a Gram-negative pathogen causing a wide range of infections from urinary tract infections to pneumonia. Kpn is a member of the so-called ESKAPE group of microorganisms, a term that emphasizes the fact that they effectively “escape” the effects of antibacterial drugs (1). Antimicrobial resistance is a significant problem for the treatment of infectious diseases cau...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Experts Concerned About Effectiveness Of This Year ’ s Flu Vaccine
(CNN) — Last year’s seasonal flu vaccine effectiveness was just 42%, the US Centers for Disease Control and Prevention estimated. Even if vaccinated, people had inadequate protection against the flu. This limited effectiveness was due to a mutation that occurred in the influenza A (H3N2) vaccine strain, according to a study published Monday in the journal Proceedings of the National Academy of Sciences. This vaccine mutation resulted from an egg-based manufacturing process commonly used today. This year’s flu vaccine may also be imperfect, said Scott Hensley, author of the new study and an associate profe...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 8, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Flu Flu Vaccine Local TV Source Type: news

Trends in preservative allergy in Cork, Ireland
Several epidemics of preservative contact allergy have emerged, namely formaldehyde in the 1960s, MCI/MI in the 1980s, methyldibromo glutaronitrile in the 1990s, and the recent epidemic of MI following European Union (EU) approval in 2005 allowing MI to be used in stronger concentrations in leave-on and rinse-off cosmetic products. The aim of our study was to evaluate the trends in preservative allergy in our dermatology unit in Cork. Over a nineteen-year period (1997 to 2015) we analyzed the patch test results of 2,636 patients who were investigated for a contact allergy.
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research

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From the desk of Shelly Flais, MDIn the past 2 decades, food allergies have more than tripled. The most common food allergies are peanuts (in the legume family), tree nuts (such as walnuts and pecans), egg, shellfish, soy, wheat, and fish. Due to this growing food allergy epidemic, continued research is investigating what can be done to prevent or treat food allergies. New studies show that children who consume peanuts at earlier ages are less likely to develop a peanut allergy. It is important to note that recommendations vary depending on if your child has severe eczema, asthma, or allergies; if this is the case, talk to...
Source: Pediatric Health Associates - January 31, 2017 Category: Pediatrics Tags: Food Allergies Healthy Habits Source Type: news

Dissemination of definitions and concepts of allergic and hypersensitivity conditions
ConclusionThis current review intends to be accepted and used universally by all health professionals involved in diseases ’ classification and coding and, therefore, contribute to improve care and outcomes in this increasing sub-section of the world’s population.
Source: World Allergy Organization Journal - August 8, 2016 Category: Allergy & Immunology Source Type: research

UCLA scientists unravel the genetic evolution of Zika virus
How does a formerly innocuous and obscure virus like Zika transform itself into a feared pathogen inflicting a devastating impact on global health? A new UCLA study suggests that the virus possesses the ability to mutate rapidly, allowing the current outbreak to spread swiftly around the world. The Cell Press journal, Cell Host & Microbe, published the findings today in its advance online edition. “The Zika virus has undergone significant genetic changes in the past 70 years,” explained senior author Genhong Cheng, a professor of microbiology, immunology and molecular genetics at the David Geffen School of Medicin...
Source: UCLA Newsroom: Health Sciences - April 15, 2016 Category: Universities & Medical Training Source Type: news

Allergies: Can Too Much Hygiene Actually Harm Us?
It's that time of the year again. You step out of the house and your eyes itch, your nose starts running and your head feels like an empty balloon. Yes, it's allergy season. Even the resilient ones, give them enough time and eventually they will develop some form of allergic reaction. But what are allergies and why do so many people suffer from them? Allergies are a glitch in our immune system. The immune system is built to recognize and destroy pathogens -- potential threats like viruses and harmful bacteria. Unlike pathogens, allergens are substances that, despite being harmless to the body, still trigger a response f...
Source: Science - The Huffington Post - April 4, 2016 Category: Science Source Type: news

European symposium on precision medicine in allergy and airways diseases: report of the European Union parliament symposium (October 14, 2015).
This report summarizes the key messages delivered during the symposium by the speakers, including the EU Commissioner for Health and Food Safety Vitenys Andriukaitis. The Commissioner underscored the need for optimal patient care in Europe, supporting joint action plans for disease prevention, patient empowerment and cost-effective treatment strategies leading to a better health status of European citizens. PMID: 26688860 [PubMed - as supplied by publisher]
Source: Rhinology - December 22, 2015 Category: ENT & OMF Tags: Rhinology Source Type: research

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