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Drug: Methotrexate

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Total 6619 results found since Jan 2013.

Preclinical drug evaluation system in the Plasmodium knowlesi baboon model of malaria: the methotrexate study
ConclusionsA protocol for preclinical drug development in the baboon was optimized. Methotrexate suppressed P. knowlesi malaria in baboons. These findings warrant further characterization of methotrexate for use in combination therapy.
Source: Journal of Medical Primatology - December 1, 2012 Category: Research Authors: M. Ichagichu, M. Ngotho, S.M. Karanja, G. Kokwaro, T. Kariuki, A. Nzila, H. Ozwara Tags: Original Article Source Type: research

Challenging the clinical relevance of folinic acid over rescue after high dose methotrexate (HDMTX)
Discussion: The rescue of high-dose MTX with an appropriate dose of folinic acid that can prevent toxicity, especially neurotoxicity, was not shown to reduce the therapeutic effect. No evidence was found that higher doses of folinic acid after high dose MTX reduces the therapeutic effect.Consequences of the hypothesis: Acceptance of the hypothesis can prevent harm being caused (especially brain damage) by reversing the trend of dose reduction in FA rescue. The recognition that the use of higher folinic acid doses is safe, can prevent neurotoxicity, and does not reduce prognosis has important implications for the developmen...
Source: Medical Hypotheses - September 16, 2013 Category: Biomedical Science Authors: Ian J. Cohen Tags: Articles Source Type: research

Late effects of chemotherapeutic agents on renal function in childhood cancer survivors: a review of the literature
Conclusion As more childhood cancer survivors are reaching adulthood, a new niche of cancer research has emerged. Researchers are now investigating the late effects due to cytotoxic treatments. Renal function impairment is a potential late effect of treatment with nephrotoxic chemotherapeutic agents including ifosfamide, cisplatin, carboplatin and methotrexate.
Source: Irish Journal of Medical Science - June 22, 2016 Category: Journals (General) Source Type: research

Migratory large vessel vasculitis preceding acute myeloid leukemia: a case report
ConclusionsLarge vessel vasculitis in older individuals presenting with atypical clinical features, such as a migratory pattern of affected vessels, vessel wall tenderness, and marked systemic inflammation, should prompt a search for underlying myelodysplasia. Clinicians should be vigilant for progression to acute myeloid leukemia.
Source: Journal of Medical Case Reports - March 15, 2017 Category: Journals (General) Source Type: research

S3 guidelines on treatment of polymyalgia rheumatica : Evidence-based guidelines of the German Society of Rheumatology (DGRh), the Austrian Society of Rheumatology and Rehabilitation ( ÖGR) and the Swiss Society of Rheumatology (SGT) and participating medical scientific specialist societies and other organizations.
[S3 guidelines on treatment of polymyalgia rheumatica : Evidence-based guidelines of the German Society of Rheumatology (DGRh), the Austrian Society of Rheumatology and Rehabilitation (ÖGR) and the Swiss Society of Rheumatology (SGT) and participating medical scientific specialist societies and other organizations]. Z Rheumatol. 2018 May 30;: Authors: Buttgereit F, DGRh, Brabant T, DGG, Dinges H, DGOOC, Hiemer I, Rheuma-Liga, Kaplani M, DGIM, Kiltz U, Kyburz D, SGR, Reißhauer A, DGPMR, Schneider M, Weseloh C, Dejaco C, ÖGR Abstract Polymyalgia rheumatica (PMR) occurs almost exclusively in persons a...
Source: Zeitschrift fur Rheumatologie - May 30, 2018 Category: Rheumatology Authors: Buttgereit F, DGRh, Brabant T, DGG, Dinges H, DGOOC, Hiemer I, Rheuma-Liga, Kaplani M, DGIM, Kiltz U, Kyburz D, SGR, Reißhauer A, DGPMR, Schneider M, Weseloh C, Dejaco C, ÖGR Tags: Z Rheumatol Source Type: research

Efficacy of methotrexate in management of peripheral psoriatic arthritis - a systematic review.
CONCLUSIONS: Clinical benefits have been found in the treatment of PsA with MTX. MTX has demonstrated clinical efficacy in the treatment of psoriasis; however, the treatment of peripheral arthritis still lacks supportive evidence. More controlled trials need to be conducted to underpin evidence-based use of MTX. PMID: 31571573 [PubMed - in process]
Source: Danish Medical Journal - October 3, 2019 Category: General Medicine Tags: Dan Med J Source Type: research

Disease-Modifying Antirheumatic Drugs (DMARDs) and drug interactions in dentistry
CONCLUSIONS: It is clinically important for oral health clinicians to be aware of possible drug interactions between DMARDs and the drugs commonly prescribed in dentistry to prevent potential adverse reactions and avoid endangering the patient.PMID:33877648 | DOI:10.26355/eurrev_202104_25536
Source: European Review for Medical and Pharmacological Sciences - April 20, 2021 Category: Drugs & Pharmacology Authors: C Mu ñoz-Martínez M Segura-Puertas G G ómez-Moreno Source Type: research

Therapeutic education improves rheumatoid arthritis patients ’ knowledge about methotrexate: a single center retrospective study
AbstractTo assess, by means of a questionnaire, the effectiveness of a therapeutic education session on rheumatoid arthritis patients ’ knowledge about methotrexate. Retrospective study of data collected in routine care. STROBE guidelines were used. Rheumatoid arthritis patients treated with methotrexate had a therapeutic education session conducted by a rheumatology nurse at time 0 and 6 months after. They completed a question naire to assess their knowledge about methotrexate before the first therapeutic education session and 6 and 12 months after. A score from 0 to 100 was calculated based on 20 questions. A total o...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research